Chitosan grafted Fe-doped WO3 decorated with gold nanoparticles for stimuli-responsive drug delivery systems
[Display omitted] •Biocompatible W0.95 Fe0.05O3-Au@C was synthesized via hydrothermal technique.•Gold functionalization improved the photo response of W0.95 Fe0.05.•The synthesized W0.95 Fe0.05O3-Au@C nanocomposite exhibited high drug release at low pH.•Dual stimuli response with pH and light furthe...
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| Veröffentlicht in: | Materials letters 2021-12, Vol.304, p.130664, Article 130664 |
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| creator | Rajalakshmi, R. Sivaselvam, S. Ponpandian, N. |
| description | [Display omitted]
•Biocompatible W0.95 Fe0.05O3-Au@C was synthesized via hydrothermal technique.•Gold functionalization improved the photo response of W0.95 Fe0.05.•The synthesized W0.95 Fe0.05O3-Au@C nanocomposite exhibited high drug release at low pH.•Dual stimuli response with pH and light further enhanced the release of Doxorubicin.
The stimuli-responsive drug delivery system (DDS) has gained much attention in the field of drug carriers to avoid premature release of drugs and on-demand delivery of drugs in response to stimuli. In the present work, we have prepared WO3-Fe-Au@C nanocomposite with dual stimuli responses like pH and light for controlling the drug release. The gold nanoparticle functionalization improves the photo-active property of the material. The WO3-Fe-Au@C exhibits good biocompatibility with L929 cells. It also exhibits higher loading efficiency of the DOX with nearly 70.2%. The WO3-Fe-Au@C exhibits pH-responsive drug release, with a higher release of drug at the acidic pH (pH-5). Under visible light irradiation, the WO3-Fe-Au@C composite effectively releases the drug at acidic pH. These results indicate that WO3-Fe-Au@C can be used as a potential drug carrier for the effective release of chemotherapy drugs to the cancer environment. |
| doi_str_mv | 10.1016/j.matlet.2021.130664 |
| format | Article |
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•Biocompatible W0.95 Fe0.05O3-Au@C was synthesized via hydrothermal technique.•Gold functionalization improved the photo response of W0.95 Fe0.05.•The synthesized W0.95 Fe0.05O3-Au@C nanocomposite exhibited high drug release at low pH.•Dual stimuli response with pH and light further enhanced the release of Doxorubicin.
The stimuli-responsive drug delivery system (DDS) has gained much attention in the field of drug carriers to avoid premature release of drugs and on-demand delivery of drugs in response to stimuli. In the present work, we have prepared WO3-Fe-Au@C nanocomposite with dual stimuli responses like pH and light for controlling the drug release. The gold nanoparticle functionalization improves the photo-active property of the material. The WO3-Fe-Au@C exhibits good biocompatibility with L929 cells. It also exhibits higher loading efficiency of the DOX with nearly 70.2%. The WO3-Fe-Au@C exhibits pH-responsive drug release, with a higher release of drug at the acidic pH (pH-5). Under visible light irradiation, the WO3-Fe-Au@C composite effectively releases the drug at acidic pH. These results indicate that WO3-Fe-Au@C can be used as a potential drug carrier for the effective release of chemotherapy drugs to the cancer environment.</description><identifier>ISSN: 0167-577X</identifier><identifier>EISSN: 1873-4979</identifier><identifier>DOI: 10.1016/j.matlet.2021.130664</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Biocompatibility ; Chitosan ; Controlled release ; Drug carriers ; Drug delivery systems ; Drug release ; Gold ; Iron ; Light irradiation ; Materials science ; Nanocomposites ; Nanoparticles ; pH-responsive delivery ; Stimuli ; Visible light</subject><ispartof>Materials letters, 2021-12, Vol.304, p.130664, Article 130664</ispartof><rights>2021 Elsevier B.V.</rights><rights>Copyright Elsevier BV Dec 1, 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c334t-5f102cb6b47c57479c319b7719f0d8f7888468155ef293e5873969de23c6fb8d3</citedby><cites>FETCH-LOGICAL-c334t-5f102cb6b47c57479c319b7719f0d8f7888468155ef293e5873969de23c6fb8d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0167577X21013616$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids></links><search><creatorcontrib>Rajalakshmi, R.</creatorcontrib><creatorcontrib>Sivaselvam, S.</creatorcontrib><creatorcontrib>Ponpandian, N.</creatorcontrib><title>Chitosan grafted Fe-doped WO3 decorated with gold nanoparticles for stimuli-responsive drug delivery systems</title><title>Materials letters</title><description>[Display omitted]
•Biocompatible W0.95 Fe0.05O3-Au@C was synthesized via hydrothermal technique.•Gold functionalization improved the photo response of W0.95 Fe0.05.•The synthesized W0.95 Fe0.05O3-Au@C nanocomposite exhibited high drug release at low pH.•Dual stimuli response with pH and light further enhanced the release of Doxorubicin.
The stimuli-responsive drug delivery system (DDS) has gained much attention in the field of drug carriers to avoid premature release of drugs and on-demand delivery of drugs in response to stimuli. In the present work, we have prepared WO3-Fe-Au@C nanocomposite with dual stimuli responses like pH and light for controlling the drug release. The gold nanoparticle functionalization improves the photo-active property of the material. The WO3-Fe-Au@C exhibits good biocompatibility with L929 cells. It also exhibits higher loading efficiency of the DOX with nearly 70.2%. The WO3-Fe-Au@C exhibits pH-responsive drug release, with a higher release of drug at the acidic pH (pH-5). Under visible light irradiation, the WO3-Fe-Au@C composite effectively releases the drug at acidic pH. These results indicate that WO3-Fe-Au@C can be used as a potential drug carrier for the effective release of chemotherapy drugs to the cancer environment.</description><subject>Biocompatibility</subject><subject>Chitosan</subject><subject>Controlled release</subject><subject>Drug carriers</subject><subject>Drug delivery systems</subject><subject>Drug release</subject><subject>Gold</subject><subject>Iron</subject><subject>Light irradiation</subject><subject>Materials science</subject><subject>Nanocomposites</subject><subject>Nanoparticles</subject><subject>pH-responsive delivery</subject><subject>Stimuli</subject><subject>Visible light</subject><issn>0167-577X</issn><issn>1873-4979</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kEtLAzEUhYMoWB__wEXA9dRkkpkkG0GKLyi4UXQXpslNTZlOxiRV-u9NGdeu7uFyzr2cD6ErSuaU0PZmM992uYc8r0lN55SRtuVHaEalYBVXQh2jWbGJqhHi4xSdpbQhhHBF-Az1i0-fQ-oGvI6dy2DxA1Q2jEW8vzBswYTYHdY_Pn_idegtHrohjF3M3vSQsAsRp-y3u95XEdIYhuS_Adu4W5d0X3Tc47RPGbbpAp24rk9w-TfP0dvD_eviqVq-PD4v7paVYYznqnGU1GbVrrgwjeBCGUbVSgiqHLHSCSklbyVtGnC1YtCUmqpVFmpmWreSlp2j6-nuGMPXDlLWm7CLQ3mp60YWZFS2vLj45DIxpBTB6TH6bRf3mhJ94Ko3euKqD1z1xLXEbqcYlAbfHqJOxsNgwPoIJmsb_P8HfgFdBYPV</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Rajalakshmi, R.</creator><creator>Sivaselvam, S.</creator><creator>Ponpandian, N.</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope></search><sort><creationdate>20211201</creationdate><title>Chitosan grafted Fe-doped WO3 decorated with gold nanoparticles for stimuli-responsive drug delivery systems</title><author>Rajalakshmi, R. ; Sivaselvam, S. ; Ponpandian, N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c334t-5f102cb6b47c57479c319b7719f0d8f7888468155ef293e5873969de23c6fb8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biocompatibility</topic><topic>Chitosan</topic><topic>Controlled release</topic><topic>Drug carriers</topic><topic>Drug delivery systems</topic><topic>Drug release</topic><topic>Gold</topic><topic>Iron</topic><topic>Light irradiation</topic><topic>Materials science</topic><topic>Nanocomposites</topic><topic>Nanoparticles</topic><topic>pH-responsive delivery</topic><topic>Stimuli</topic><topic>Visible light</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rajalakshmi, R.</creatorcontrib><creatorcontrib>Sivaselvam, S.</creatorcontrib><creatorcontrib>Ponpandian, N.</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Materials letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rajalakshmi, R.</au><au>Sivaselvam, S.</au><au>Ponpandian, N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chitosan grafted Fe-doped WO3 decorated with gold nanoparticles for stimuli-responsive drug delivery systems</atitle><jtitle>Materials letters</jtitle><date>2021-12-01</date><risdate>2021</risdate><volume>304</volume><spage>130664</spage><pages>130664-</pages><artnum>130664</artnum><issn>0167-577X</issn><eissn>1873-4979</eissn><abstract>[Display omitted]
•Biocompatible W0.95 Fe0.05O3-Au@C was synthesized via hydrothermal technique.•Gold functionalization improved the photo response of W0.95 Fe0.05.•The synthesized W0.95 Fe0.05O3-Au@C nanocomposite exhibited high drug release at low pH.•Dual stimuli response with pH and light further enhanced the release of Doxorubicin.
The stimuli-responsive drug delivery system (DDS) has gained much attention in the field of drug carriers to avoid premature release of drugs and on-demand delivery of drugs in response to stimuli. In the present work, we have prepared WO3-Fe-Au@C nanocomposite with dual stimuli responses like pH and light for controlling the drug release. The gold nanoparticle functionalization improves the photo-active property of the material. The WO3-Fe-Au@C exhibits good biocompatibility with L929 cells. It also exhibits higher loading efficiency of the DOX with nearly 70.2%. The WO3-Fe-Au@C exhibits pH-responsive drug release, with a higher release of drug at the acidic pH (pH-5). Under visible light irradiation, the WO3-Fe-Au@C composite effectively releases the drug at acidic pH. These results indicate that WO3-Fe-Au@C can be used as a potential drug carrier for the effective release of chemotherapy drugs to the cancer environment.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><doi>10.1016/j.matlet.2021.130664</doi></addata></record> |
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| subjects | Biocompatibility Chitosan Controlled release Drug carriers Drug delivery systems Drug release Gold Iron Light irradiation Materials science Nanocomposites Nanoparticles pH-responsive delivery Stimuli Visible light |
| title | Chitosan grafted Fe-doped WO3 decorated with gold nanoparticles for stimuli-responsive drug delivery systems |
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