Analysis of sex differences in the clinical presentation, management and prognosis of infective endocarditis in Spain
IntroductionSex-dependent differences of infective endocarditis (IE) have been reported. Women suffer from IE less frequently than men and tend to present more severe manifestations. Our objective was to analyse the sex-based differences of IE in the clinical presentation, treatment, and prognosis.M...
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| Veröffentlicht in: | Heart (British Cardiac Society) 2021-11, Vol.107 (21), p.1717-1724 |
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| creator | Varela Barca, Laura Valerio Minero, Maricela Gutiérrez Carretero, Encarnacion Moreno Camacho, Asuncion Ojeda Burgos, Guillermo López-Cortés, Luis Eduardo Noureddine, Mariam Blanco, Roberto Boado, María Victoria Crespo, Alejandro López-Soria, Leire Montejo, Miguel Rodrigo, David Rodríguez, Regino Vitoria, Yolanda Voces, Roberto Ojeda, Guillermo Odriozola, Ma Jesús Bustinduy Yarza, Alberto Eizaguirre Goenaga, Miguel Ángel Bauza, Ángela Granda López, Jose Pérez-Moreiras Plazas, Joaquín Bravo-Ferrer, JoséMaría Llinares, Pedro Martínez, Francisco Javier Rosado, Dácil García González, Julia González Peña, Lissete Lorenzo de la Álvarez, Víctor Asensi Suárez, Jonnathan Fernández Menéndez, José López Bajo, Pilar Mencia Morales, Carlos Palomo, Carmen Martínez, Begoña Paya Esteban, Ángeles Rodríguez Ambrosioni, Juan Marco, Francesc Pericás, Juan M Ramírez, José Sandoval, Elena Téllez, Adrián Vila, Jordi Bermejo, Javier Bouza, Emilio Mansilla, Ana García Vázquez, Pilar Moreno, Eduardo Verde Antorrena, Isabel Rosillo, Sandra Gutiérrez-Cuadra, Manuel Parra, José Antonio Zarauza, Jesús Cobo, Marta Domínguez, Fernando Cruz, Ana Fernández Centella, Tomasa Hermida, José Manuel Martín-Dávila, Pilar Navas, Enrique Oliva, Enrique Araji, Omar Acebal, Juan Gálvez Morales, Isabel García, Emilio Haro, Juan Luis Lepe, José Antonio Luque, Rafael Azcárate, Pedro Oteo, José Antonio Gurguí, Mercé Pacho, Cristina Pericas, Roser Blasco, Andrés Canut Arana, Juan Gainzarain Matos, José Urturi Antonio, Sánchez-Porto Alejandro, Úbeda Iglesias Torres, Alicia Hernández Yañez, Ivan Keituqwa Ballesta, Ana Peláez Escobar, Eduardo Moreno Seco, Ma Cruz Pérez Gelabert, Aroa Villoslada Abad, Nuria Fernández Caro, José Giner JiménezSánchez, Roberto González, Monserrat Viqueira Blanco, Ma Ángels Ribas Bonet, Laura Vidal Garaizabal, Elena Escribano Peiretti, María Corres Robles, José García Medrano, Francisco López Gude, Ma Jesús López Morales, Juan Ruiz Solís, Sebastián Ruiz Grillo, Sara Lobato, Miguel Navas |
| description | IntroductionSex-dependent differences of infective endocarditis (IE) have been reported. Women suffer from IE less frequently than men and tend to present more severe manifestations. Our objective was to analyse the sex-based differences of IE in the clinical presentation, treatment, and prognosis.Material and methodsWe analysed the sex differences in the clinical presentation, modality of treatment and prognosis of IE in a national-level multicentric cohort between 2008 and 2018. All data were prospectively recorded by the GAMES cohort (Spanish Collaboration on Endocarditis).ResultsA total of 3451 patients were included, of whom 1105 were women (32.0%). Women were older than men (mean age, 68.4 vs 64.5). The most frequently affected valves were the aortic valve in men (50.6%) and mitral valve in women (48.7%). Staphylococcus aureus aetiology was more frequent in women (30.1% vs 23.1%; p |
| doi_str_mv | 10.1136/heartjnl-2021-319254 |
| format | Article |
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Valerio Minero, Maricela ; Gutiérrez Carretero, Encarnacion ; Moreno Camacho, Asuncion ; Ojeda Burgos, Guillermo ; López-Cortés, Luis Eduardo ; Noureddine, Mariam ; Blanco, Roberto ; Boado, María Victoria ; Crespo, Alejandro ; López-Soria, Leire ; Montejo, Miguel ; Rodrigo, David ; Rodríguez, Regino ; Vitoria, Yolanda ; Voces, Roberto ; Ojeda, Guillermo ; Odriozola, Ma Jesús Bustinduy ; Yarza, Alberto Eizaguirre ; Goenaga, Miguel Ángel ; Bauza, Ángela Granda ; López, Jose Pérez-Moreiras ; Plazas, Joaquín ; Bravo-Ferrer, JoséMaría ; Llinares, Pedro ; Martínez, Francisco Javier ; Rosado, Dácil García ; González, Julia González ; Peña, Lissete Lorenzo de la ; Álvarez, Víctor Asensi ; Suárez, Jonnathan Fernández ; Menéndez, José López ; Bajo, Pilar Mencia ; Morales, Carlos ; Palomo, Carmen ; Martínez, Begoña Paya ; Esteban, Ángeles Rodríguez ; Ambrosioni, Juan ; Marco, Francesc ; Pericás, Juan M ; Ramírez, José ; Sandoval, Elena ; Téllez, Adrián ; Vila, Jordi ; Bermejo, Javier ; Bouza, Emilio ; Mansilla, Ana García ; Vázquez, Pilar ; Moreno, Eduardo Verde ; Antorrena, Isabel ; Rosillo, Sandra ; Gutiérrez-Cuadra, Manuel ; Parra, José Antonio ; Zarauza, Jesús ; Cobo, Marta ; Domínguez, Fernando ; Cruz, Ana Fernández ; Centella, Tomasa ; Hermida, José Manuel ; Martín-Dávila, Pilar ; Navas, Enrique ; Oliva, Enrique ; Araji, Omar ; Acebal, Juan Gálvez ; Morales, Isabel ; García, Emilio ; Haro, Juan Luis ; Lepe, José Antonio ; Luque, Rafael ; Azcárate, Pedro ; Oteo, José Antonio ; Gurguí, Mercé ; Pacho, Cristina ; Pericas, Roser ; Blasco, Andrés Canut ; Arana, Juan Gainzarain ; Matos, José Urturi ; Antonio, Sánchez-Porto ; Alejandro, Úbeda Iglesias ; Torres, Alicia Hernández ; Yañez, Ivan Keituqwa ; Ballesta, Ana Peláez ; Escobar, Eduardo Moreno ; Seco, Ma Cruz Pérez ; Gelabert, Aroa Villoslada ; Abad, Nuria Fernández ; Caro, José Giner ; JiménezSánchez, Roberto ; González, Monserrat Viqueira ; Blanco, Ma Ángels Ribas ; Bonet, Laura Vidal ; Garaizabal, Elena Escribano ; Peiretti, María Corres ; Robles, José García ; Medrano, Francisco López ; Gude, Ma Jesús López ; Morales, Juan Ruiz ; Solís, Sebastián Ruiz ; Grillo, Sara ; Lobato, Miguel Navas</creator><creatorcontrib>Varela Barca, Laura ; Valerio Minero, Maricela ; Gutiérrez Carretero, Encarnacion ; Moreno Camacho, Asuncion ; Ojeda Burgos, Guillermo ; López-Cortés, Luis Eduardo ; Noureddine, Mariam ; Blanco, Roberto ; Boado, María Victoria ; Crespo, Alejandro ; López-Soria, Leire ; Montejo, Miguel ; Rodrigo, David ; Rodríguez, Regino ; Vitoria, Yolanda ; Voces, Roberto ; Ojeda, Guillermo ; Odriozola, Ma Jesús Bustinduy ; Yarza, Alberto Eizaguirre ; Goenaga, Miguel Ángel ; Bauza, Ángela Granda ; López, Jose Pérez-Moreiras ; Plazas, Joaquín ; Bravo-Ferrer, JoséMaría ; Llinares, Pedro ; Martínez, Francisco Javier ; Rosado, Dácil García ; González, Julia González ; Peña, Lissete Lorenzo de la ; Álvarez, Víctor Asensi ; Suárez, Jonnathan Fernández ; Menéndez, José López ; Bajo, Pilar Mencia ; Morales, Carlos ; Palomo, Carmen ; Martínez, Begoña Paya ; Esteban, Ángeles Rodríguez ; Ambrosioni, Juan ; Marco, Francesc ; Pericás, Juan M ; Ramírez, José ; Sandoval, Elena ; Téllez, Adrián ; Vila, Jordi ; Bermejo, Javier ; Bouza, Emilio ; Mansilla, Ana García ; Vázquez, Pilar ; Moreno, Eduardo Verde ; Antorrena, Isabel ; Rosillo, Sandra ; Gutiérrez-Cuadra, Manuel ; Parra, José Antonio ; Zarauza, Jesús ; Cobo, Marta ; Domínguez, Fernando ; Cruz, Ana Fernández ; Centella, Tomasa ; Hermida, José Manuel ; Martín-Dávila, Pilar ; Navas, Enrique ; Oliva, Enrique ; Araji, Omar ; Acebal, Juan Gálvez ; Morales, Isabel ; García, Emilio ; Haro, Juan Luis ; Lepe, José Antonio ; Luque, Rafael ; Azcárate, Pedro ; Oteo, José Antonio ; Gurguí, Mercé ; Pacho, Cristina ; Pericas, Roser ; Blasco, Andrés Canut ; Arana, Juan Gainzarain ; Matos, José Urturi ; Antonio, Sánchez-Porto ; Alejandro, Úbeda Iglesias ; Torres, Alicia Hernández ; Yañez, Ivan Keituqwa ; Ballesta, Ana Peláez ; Escobar, Eduardo Moreno ; Seco, Ma Cruz Pérez ; Gelabert, Aroa Villoslada ; Abad, Nuria Fernández ; Caro, José Giner ; JiménezSánchez, Roberto ; González, Monserrat Viqueira ; Blanco, Ma Ángels Ribas ; Bonet, Laura Vidal ; Garaizabal, Elena Escribano ; Peiretti, María Corres ; Robles, José García ; Medrano, Francisco López ; Gude, Ma Jesús López ; Morales, Juan Ruiz ; Solís, Sebastián Ruiz ; Grillo, Sara ; Lobato, Miguel Navas ; GAMES Investigators</creatorcontrib><description>IntroductionSex-dependent differences of infective endocarditis (IE) have been reported. Women suffer from IE less frequently than men and tend to present more severe manifestations. Our objective was to analyse the sex-based differences of IE in the clinical presentation, treatment, and prognosis.Material and methodsWe analysed the sex differences in the clinical presentation, modality of treatment and prognosis of IE in a national-level multicentric cohort between 2008 and 2018. All data were prospectively recorded by the GAMES cohort (Spanish Collaboration on Endocarditis).ResultsA total of 3451 patients were included, of whom 1105 were women (32.0%). Women were older than men (mean age, 68.4 vs 64.5). The most frequently affected valves were the aortic valve in men (50.6%) and mitral valve in women (48.7%). Staphylococcus aureus aetiology was more frequent in women (30.1% vs 23.1%; p<0.001).Surgery was performed in 38.3% of women and 50% of men. After propensity score (PS) matching for age and estimated surgical risk (European System for Cardiac Operative Risk Evaluation II (EuroSCORE II)), the analysis of the matched cohorts revealed that women were less likely to undergo surgery (OR 0.74; 95% CI 0.59 to 0.91; p=0.05).The observed overall in-hospital mortality was 32.8% in women and 25.7% in men (OR for the mortality of female sex 1.41; 95% CI 1.21 to 1.65; p<0.001). This statistical difference was not modified after adjusting for all possible confounders.ConclusionsFemale sex was an independent factor related to mortality after adjusting for confounders. In addition, women were less frequently referred for surgical treatment.</description><identifier>ISSN: 1355-6037</identifier><identifier>EISSN: 1468-201X</identifier><identifier>DOI: 10.1136/heartjnl-2021-319254</identifier><identifier>PMID: 34290038</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and British Cardiovascular Society</publisher><subject>Abscesses ; Aged ; Cardiac risk factors and prevention ; Collaboration ; Creatinine ; Disease Management ; Embolisms ; Endocarditis ; Endocarditis - diagnosis ; Endocarditis - epidemiology ; Endocarditis - therapy ; Female ; Females ; Follow-Up Studies ; Gender differences ; Heart surgery ; heart valve prosthesis implantation ; Hospital Mortality - trends ; Hospitals ; Humans ; Infections ; Male ; Morbidity - trends ; Mortality ; Prognosis ; Propensity Score ; Prospective Studies ; Prostheses ; Risk Assessment - methods ; risk factors ; Sex Distribution ; Sex Factors ; Sexes ; Spain - epidemiology ; Statistical analysis ; Surgical outcomes ; Survival Rate - trends ; Womens health</subject><ispartof>Heart (British Cardiac Society), 2021-11, Vol.107 (21), p.1717-1724</ispartof><rights>Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2021 Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b449t-8e5ee5a3868c3213be230681ee5b9eb26663c9db0383dc8e4decbd731c91c8cb3</citedby><cites>FETCH-LOGICAL-b449t-8e5ee5a3868c3213be230681ee5b9eb26663c9db0383dc8e4decbd731c91c8cb3</cites><orcidid>0000-0002-4605-8801 ; 0000-0002-4627-2277</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34290038$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Varela Barca, Laura</creatorcontrib><creatorcontrib>Valerio Minero, Maricela</creatorcontrib><creatorcontrib>Gutiérrez Carretero, Encarnacion</creatorcontrib><creatorcontrib>Moreno Camacho, Asuncion</creatorcontrib><creatorcontrib>Ojeda Burgos, Guillermo</creatorcontrib><creatorcontrib>López-Cortés, Luis Eduardo</creatorcontrib><creatorcontrib>Noureddine, Mariam</creatorcontrib><creatorcontrib>Blanco, Roberto</creatorcontrib><creatorcontrib>Boado, María Victoria</creatorcontrib><creatorcontrib>Crespo, Alejandro</creatorcontrib><creatorcontrib>López-Soria, Leire</creatorcontrib><creatorcontrib>Montejo, Miguel</creatorcontrib><creatorcontrib>Rodrigo, David</creatorcontrib><creatorcontrib>Rodríguez, Regino</creatorcontrib><creatorcontrib>Vitoria, Yolanda</creatorcontrib><creatorcontrib>Voces, Roberto</creatorcontrib><creatorcontrib>Ojeda, Guillermo</creatorcontrib><creatorcontrib>Odriozola, Ma Jesús Bustinduy</creatorcontrib><creatorcontrib>Yarza, Alberto Eizaguirre</creatorcontrib><creatorcontrib>Goenaga, Miguel Ángel</creatorcontrib><creatorcontrib>Bauza, Ángela Granda</creatorcontrib><creatorcontrib>López, Jose Pérez-Moreiras</creatorcontrib><creatorcontrib>Plazas, Joaquín</creatorcontrib><creatorcontrib>Bravo-Ferrer, JoséMaría</creatorcontrib><creatorcontrib>Llinares, Pedro</creatorcontrib><creatorcontrib>Martínez, Francisco Javier</creatorcontrib><creatorcontrib>Rosado, Dácil García</creatorcontrib><creatorcontrib>González, Julia González</creatorcontrib><creatorcontrib>Peña, Lissete Lorenzo de la</creatorcontrib><creatorcontrib>Álvarez, Víctor Asensi</creatorcontrib><creatorcontrib>Suárez, Jonnathan Fernández</creatorcontrib><creatorcontrib>Menéndez, José López</creatorcontrib><creatorcontrib>Bajo, Pilar Mencia</creatorcontrib><creatorcontrib>Morales, Carlos</creatorcontrib><creatorcontrib>Palomo, Carmen</creatorcontrib><creatorcontrib>Martínez, Begoña Paya</creatorcontrib><creatorcontrib>Esteban, Ángeles Rodríguez</creatorcontrib><creatorcontrib>Ambrosioni, Juan</creatorcontrib><creatorcontrib>Marco, Francesc</creatorcontrib><creatorcontrib>Pericás, Juan M</creatorcontrib><creatorcontrib>Ramírez, José</creatorcontrib><creatorcontrib>Sandoval, Elena</creatorcontrib><creatorcontrib>Téllez, Adrián</creatorcontrib><creatorcontrib>Vila, Jordi</creatorcontrib><creatorcontrib>Bermejo, Javier</creatorcontrib><creatorcontrib>Bouza, Emilio</creatorcontrib><creatorcontrib>Mansilla, Ana García</creatorcontrib><creatorcontrib>Vázquez, Pilar</creatorcontrib><creatorcontrib>Moreno, Eduardo Verde</creatorcontrib><creatorcontrib>Antorrena, Isabel</creatorcontrib><creatorcontrib>Rosillo, Sandra</creatorcontrib><creatorcontrib>Gutiérrez-Cuadra, Manuel</creatorcontrib><creatorcontrib>Parra, José Antonio</creatorcontrib><creatorcontrib>Zarauza, Jesús</creatorcontrib><creatorcontrib>Cobo, Marta</creatorcontrib><creatorcontrib>Domínguez, Fernando</creatorcontrib><creatorcontrib>Cruz, Ana Fernández</creatorcontrib><creatorcontrib>Centella, Tomasa</creatorcontrib><creatorcontrib>Hermida, José Manuel</creatorcontrib><creatorcontrib>Martín-Dávila, Pilar</creatorcontrib><creatorcontrib>Navas, Enrique</creatorcontrib><creatorcontrib>Oliva, Enrique</creatorcontrib><creatorcontrib>Araji, Omar</creatorcontrib><creatorcontrib>Acebal, Juan Gálvez</creatorcontrib><creatorcontrib>Morales, Isabel</creatorcontrib><creatorcontrib>García, Emilio</creatorcontrib><creatorcontrib>Haro, Juan Luis</creatorcontrib><creatorcontrib>Lepe, José Antonio</creatorcontrib><creatorcontrib>Luque, Rafael</creatorcontrib><creatorcontrib>Azcárate, Pedro</creatorcontrib><creatorcontrib>Oteo, José Antonio</creatorcontrib><creatorcontrib>Gurguí, Mercé</creatorcontrib><creatorcontrib>Pacho, Cristina</creatorcontrib><creatorcontrib>Pericas, Roser</creatorcontrib><creatorcontrib>Blasco, Andrés Canut</creatorcontrib><creatorcontrib>Arana, Juan Gainzarain</creatorcontrib><creatorcontrib>Matos, José Urturi</creatorcontrib><creatorcontrib>Antonio, Sánchez-Porto</creatorcontrib><creatorcontrib>Alejandro, Úbeda Iglesias</creatorcontrib><creatorcontrib>Torres, Alicia Hernández</creatorcontrib><creatorcontrib>Yañez, Ivan Keituqwa</creatorcontrib><creatorcontrib>Ballesta, Ana Peláez</creatorcontrib><creatorcontrib>Escobar, Eduardo Moreno</creatorcontrib><creatorcontrib>Seco, Ma Cruz Pérez</creatorcontrib><creatorcontrib>Gelabert, Aroa Villoslada</creatorcontrib><creatorcontrib>Abad, Nuria Fernández</creatorcontrib><creatorcontrib>Caro, José Giner</creatorcontrib><creatorcontrib>JiménezSánchez, Roberto</creatorcontrib><creatorcontrib>González, Monserrat Viqueira</creatorcontrib><creatorcontrib>Blanco, Ma Ángels Ribas</creatorcontrib><creatorcontrib>Bonet, Laura Vidal</creatorcontrib><creatorcontrib>Garaizabal, Elena Escribano</creatorcontrib><creatorcontrib>Peiretti, María Corres</creatorcontrib><creatorcontrib>Robles, José García</creatorcontrib><creatorcontrib>Medrano, Francisco López</creatorcontrib><creatorcontrib>Gude, Ma Jesús López</creatorcontrib><creatorcontrib>Morales, Juan Ruiz</creatorcontrib><creatorcontrib>Solís, Sebastián Ruiz</creatorcontrib><creatorcontrib>Grillo, Sara</creatorcontrib><creatorcontrib>Lobato, Miguel Navas</creatorcontrib><creatorcontrib>GAMES Investigators</creatorcontrib><title>Analysis of sex differences in the clinical presentation, management and prognosis of infective endocarditis in Spain</title><title>Heart (British Cardiac Society)</title><addtitle>Heart</addtitle><addtitle>Heart</addtitle><description>IntroductionSex-dependent differences of infective endocarditis (IE) have been reported. Women suffer from IE less frequently than men and tend to present more severe manifestations. Our objective was to analyse the sex-based differences of IE in the clinical presentation, treatment, and prognosis.Material and methodsWe analysed the sex differences in the clinical presentation, modality of treatment and prognosis of IE in a national-level multicentric cohort between 2008 and 2018. All data were prospectively recorded by the GAMES cohort (Spanish Collaboration on Endocarditis).ResultsA total of 3451 patients were included, of whom 1105 were women (32.0%). Women were older than men (mean age, 68.4 vs 64.5). The most frequently affected valves were the aortic valve in men (50.6%) and mitral valve in women (48.7%). Staphylococcus aureus aetiology was more frequent in women (30.1% vs 23.1%; p<0.001).Surgery was performed in 38.3% of women and 50% of men. After propensity score (PS) matching for age and estimated surgical risk (European System for Cardiac Operative Risk Evaluation II (EuroSCORE II)), the analysis of the matched cohorts revealed that women were less likely to undergo surgery (OR 0.74; 95% CI 0.59 to 0.91; p=0.05).The observed overall in-hospital mortality was 32.8% in women and 25.7% in men (OR for the mortality of female sex 1.41; 95% CI 1.21 to 1.65; p<0.001). This statistical difference was not modified after adjusting for all possible confounders.ConclusionsFemale sex was an independent factor related to mortality after adjusting for confounders. In addition, women were less frequently referred for surgical treatment.</description><subject>Abscesses</subject><subject>Aged</subject><subject>Cardiac risk factors and prevention</subject><subject>Collaboration</subject><subject>Creatinine</subject><subject>Disease Management</subject><subject>Embolisms</subject><subject>Endocarditis</subject><subject>Endocarditis - diagnosis</subject><subject>Endocarditis - epidemiology</subject><subject>Endocarditis - therapy</subject><subject>Female</subject><subject>Females</subject><subject>Follow-Up Studies</subject><subject>Gender differences</subject><subject>Heart surgery</subject><subject>heart valve prosthesis implantation</subject><subject>Hospital Mortality - trends</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infections</subject><subject>Male</subject><subject>Morbidity - trends</subject><subject>Mortality</subject><subject>Prognosis</subject><subject>Propensity Score</subject><subject>Prospective Studies</subject><subject>Prostheses</subject><subject>Risk Assessment - methods</subject><subject>risk factors</subject><subject>Sex Distribution</subject><subject>Sex Factors</subject><subject>Sexes</subject><subject>Spain - epidemiology</subject><subject>Statistical analysis</subject><subject>Surgical outcomes</subject><subject>Survival Rate - trends</subject><subject>Womens 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Maricela</creator><creator>Gutiérrez Carretero, Encarnacion</creator><creator>Moreno Camacho, Asuncion</creator><creator>Ojeda Burgos, Guillermo</creator><creator>López-Cortés, Luis Eduardo</creator><creator>Noureddine, Mariam</creator><creator>Blanco, Roberto</creator><creator>Boado, María Victoria</creator><creator>Crespo, Alejandro</creator><creator>López-Soria, Leire</creator><creator>Montejo, Miguel</creator><creator>Rodrigo, David</creator><creator>Rodríguez, Regino</creator><creator>Vitoria, Yolanda</creator><creator>Voces, Roberto</creator><creator>Ojeda, Guillermo</creator><creator>Odriozola, Ma Jesús Bustinduy</creator><creator>Yarza, Alberto Eizaguirre</creator><creator>Goenaga, Miguel Ángel</creator><creator>Bauza, Ángela Granda</creator><creator>López, Jose Pérez-Moreiras</creator><creator>Plazas, Joaquín</creator><creator>Bravo-Ferrer, JoséMaría</creator><creator>Llinares, Pedro</creator><creator>Martínez, Francisco Javier</creator><creator>Rosado, Dácil 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LTD</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><orcidid>https://orcid.org/0000-0002-4605-8801</orcidid><orcidid>https://orcid.org/0000-0002-4627-2277</orcidid></search><sort><creationdate>20211101</creationdate><title>Analysis of sex differences in the clinical presentation, management and prognosis of infective endocarditis in Spain</title><author>Varela Barca, Laura ; Valerio Minero, Maricela ; Gutiérrez Carretero, Encarnacion ; Moreno Camacho, Asuncion ; Ojeda Burgos, Guillermo ; López-Cortés, Luis Eduardo ; Noureddine, Mariam ; Blanco, Roberto ; Boado, María Victoria ; Crespo, Alejandro ; López-Soria, Leire ; Montejo, Miguel ; Rodrigo, David ; Rodríguez, Regino ; Vitoria, Yolanda ; Voces, Roberto ; Ojeda, Guillermo ; Odriozola, Ma Jesús Bustinduy ; Yarza, Alberto Eizaguirre ; Goenaga, Miguel Ángel ; Bauza, Ángela Granda ; López, Jose Pérez-Moreiras ; Plazas, Joaquín ; Bravo-Ferrer, JoséMaría ; Llinares, Pedro ; Martínez, Francisco Javier ; Rosado, Dácil García ; González, Julia González ; Peña, Lissete Lorenzo de la ; Álvarez, Víctor Asensi ; Suárez, Jonnathan Fernández ; Menéndez, José López ; Bajo, Pilar Mencia ; Morales, Carlos ; Palomo, Carmen ; Martínez, Begoña Paya ; Esteban, Ángeles Rodríguez ; Ambrosioni, Juan ; Marco, Francesc ; Pericás, Juan M ; Ramírez, José ; Sandoval, Elena ; Téllez, Adrián ; Vila, Jordi ; Bermejo, Javier ; Bouza, Emilio ; Mansilla, Ana García ; Vázquez, Pilar ; Moreno, Eduardo Verde ; Antorrena, Isabel ; Rosillo, Sandra ; Gutiérrez-Cuadra, Manuel ; Parra, José Antonio ; Zarauza, Jesús ; Cobo, Marta ; Domínguez, Fernando ; Cruz, Ana Fernández ; Centella, Tomasa ; Hermida, José Manuel ; Martín-Dávila, Pilar ; Navas, Enrique ; Oliva, Enrique ; Araji, Omar ; Acebal, Juan Gálvez ; Morales, Isabel ; García, Emilio ; Haro, Juan Luis ; Lepe, José Antonio ; Luque, Rafael ; Azcárate, Pedro ; Oteo, José Antonio ; Gurguí, Mercé ; Pacho, Cristina ; Pericas, Roser ; Blasco, Andrés Canut ; Arana, Juan Gainzarain ; Matos, José Urturi ; Antonio, Sánchez-Porto ; Alejandro, Úbeda Iglesias ; Torres, Alicia Hernández ; Yañez, Ivan Keituqwa ; Ballesta, Ana Peláez ; Escobar, Eduardo Moreno ; Seco, Ma Cruz Pérez ; Gelabert, Aroa Villoslada ; Abad, Nuria Fernández ; Caro, José Giner ; JiménezSánchez, Roberto ; González, Monserrat Viqueira ; Blanco, Ma Ángels Ribas ; Bonet, Laura Vidal ; Garaizabal, Elena Escribano ; Peiretti, María Corres ; Robles, José García ; Medrano, Francisco López ; Gude, Ma Jesús López ; Morales, Juan Ruiz ; Solís, Sebastián Ruiz ; Grillo, Sara ; Lobato, Miguel Navas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b449t-8e5ee5a3868c3213be230681ee5b9eb26663c9db0383dc8e4decbd731c91c8cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Abscesses</topic><topic>Aged</topic><topic>Cardiac risk factors and prevention</topic><topic>Collaboration</topic><topic>Creatinine</topic><topic>Disease Management</topic><topic>Embolisms</topic><topic>Endocarditis</topic><topic>Endocarditis - diagnosis</topic><topic>Endocarditis - epidemiology</topic><topic>Endocarditis - therapy</topic><topic>Female</topic><topic>Females</topic><topic>Follow-Up Studies</topic><topic>Gender differences</topic><topic>Heart surgery</topic><topic>heart valve 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Navas</creatorcontrib><creatorcontrib>GAMES Investigators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Heart (British Cardiac Society)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Varela Barca, Laura</au><au>Valerio Minero, Maricela</au><au>Gutiérrez Carretero, Encarnacion</au><au>Moreno Camacho, Asuncion</au><au>Ojeda Burgos, Guillermo</au><au>López-Cortés, Luis Eduardo</au><au>Noureddine, Mariam</au><au>Blanco, Roberto</au><au>Boado, María Victoria</au><au>Crespo, Alejandro</au><au>López-Soria, Leire</au><au>Montejo, Miguel</au><au>Rodrigo, David</au><au>Rodríguez, Regino</au><au>Vitoria, Yolanda</au><au>Voces, Roberto</au><au>Ojeda, Guillermo</au><au>Odriozola, Ma Jesús Bustinduy</au><au>Yarza, Alberto Eizaguirre</au><au>Goenaga, Miguel Ángel</au><au>Bauza, Ángela Granda</au><au>López, Jose Pérez-Moreiras</au><au>Plazas, Joaquín</au><au>Bravo-Ferrer, JoséMaría</au><au>Llinares, Pedro</au><au>Martínez, Francisco Javier</au><au>Rosado, Dácil García</au><au>González, Julia González</au><au>Peña, Lissete Lorenzo de la</au><au>Álvarez, Víctor Asensi</au><au>Suárez, Jonnathan Fernández</au><au>Menéndez, José López</au><au>Bajo, Pilar Mencia</au><au>Morales, Carlos</au><au>Palomo, Carmen</au><au>Martínez, Begoña Paya</au><au>Esteban, Ángeles Rodríguez</au><au>Ambrosioni, Juan</au><au>Marco, Francesc</au><au>Pericás, Juan M</au><au>Ramírez, José</au><au>Sandoval, Elena</au><au>Téllez, Adrián</au><au>Vila, Jordi</au><au>Bermejo, Javier</au><au>Bouza, Emilio</au><au>Mansilla, Ana García</au><au>Vázquez, Pilar</au><au>Moreno, Eduardo Verde</au><au>Antorrena, Isabel</au><au>Rosillo, Sandra</au><au>Gutiérrez-Cuadra, Manuel</au><au>Parra, José Antonio</au><au>Zarauza, Jesús</au><au>Cobo, Marta</au><au>Domínguez, Fernando</au><au>Cruz, Ana Fernández</au><au>Centella, Tomasa</au><au>Hermida, José Manuel</au><au>Martín-Dávila, Pilar</au><au>Navas, Enrique</au><au>Oliva, Enrique</au><au>Araji, Omar</au><au>Acebal, Juan Gálvez</au><au>Morales, Isabel</au><au>García, Emilio</au><au>Haro, Juan Luis</au><au>Lepe, José Antonio</au><au>Luque, Rafael</au><au>Azcárate, Pedro</au><au>Oteo, José Antonio</au><au>Gurguí, Mercé</au><au>Pacho, Cristina</au><au>Pericas, Roser</au><au>Blasco, Andrés Canut</au><au>Arana, Juan Gainzarain</au><au>Matos, José Urturi</au><au>Antonio, Sánchez-Porto</au><au>Alejandro, Úbeda Iglesias</au><au>Torres, Alicia Hernández</au><au>Yañez, Ivan Keituqwa</au><au>Ballesta, Ana Peláez</au><au>Escobar, Eduardo Moreno</au><au>Seco, Ma Cruz Pérez</au><au>Gelabert, Aroa Villoslada</au><au>Abad, Nuria Fernández</au><au>Caro, José Giner</au><au>JiménezSánchez, Roberto</au><au>González, Monserrat Viqueira</au><au>Blanco, Ma Ángels Ribas</au><au>Bonet, Laura Vidal</au><au>Garaizabal, Elena Escribano</au><au>Peiretti, María Corres</au><au>Robles, José García</au><au>Medrano, Francisco López</au><au>Gude, Ma Jesús López</au><au>Morales, Juan Ruiz</au><au>Solís, Sebastián Ruiz</au><au>Grillo, Sara</au><au>Lobato, Miguel Navas</au><aucorp>GAMES Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of sex differences in the clinical presentation, management and prognosis of infective endocarditis in Spain</atitle><jtitle>Heart (British Cardiac Society)</jtitle><stitle>Heart</stitle><addtitle>Heart</addtitle><date>2021-11-01</date><risdate>2021</risdate><volume>107</volume><issue>21</issue><spage>1717</spage><epage>1724</epage><pages>1717-1724</pages><issn>1355-6037</issn><eissn>1468-201X</eissn><abstract>IntroductionSex-dependent differences of infective endocarditis (IE) have been reported. Women suffer from IE less frequently than men and tend to present more severe manifestations. Our objective was to analyse the sex-based differences of IE in the clinical presentation, treatment, and prognosis.Material and methodsWe analysed the sex differences in the clinical presentation, modality of treatment and prognosis of IE in a national-level multicentric cohort between 2008 and 2018. All data were prospectively recorded by the GAMES cohort (Spanish Collaboration on Endocarditis).ResultsA total of 3451 patients were included, of whom 1105 were women (32.0%). Women were older than men (mean age, 68.4 vs 64.5). The most frequently affected valves were the aortic valve in men (50.6%) and mitral valve in women (48.7%). Staphylococcus aureus aetiology was more frequent in women (30.1% vs 23.1%; p<0.001).Surgery was performed in 38.3% of women and 50% of men. After propensity score (PS) matching for age and estimated surgical risk (European System for Cardiac Operative Risk Evaluation II (EuroSCORE II)), the analysis of the matched cohorts revealed that women were less likely to undergo surgery (OR 0.74; 95% CI 0.59 to 0.91; p=0.05).The observed overall in-hospital mortality was 32.8% in women and 25.7% in men (OR for the mortality of female sex 1.41; 95% CI 1.21 to 1.65; p<0.001). This statistical difference was not modified after adjusting for all possible confounders.ConclusionsFemale sex was an independent factor related to mortality after adjusting for confounders. In addition, women were less frequently referred for surgical treatment.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and British Cardiovascular Society</pub><pmid>34290038</pmid><doi>10.1136/heartjnl-2021-319254</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-4605-8801</orcidid><orcidid>https://orcid.org/0000-0002-4627-2277</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1355-6037 |
| ispartof | Heart (British Cardiac Society), 2021-11, Vol.107 (21), p.1717-1724 |
| issn | 1355-6037 1468-201X |
| language | eng |
| recordid | cdi_proquest_journals_2580848595 |
| source | MEDLINE; PubMed Central |
| subjects | Abscesses Aged Cardiac risk factors and prevention Collaboration Creatinine Disease Management Embolisms Endocarditis Endocarditis - diagnosis Endocarditis - epidemiology Endocarditis - therapy Female Females Follow-Up Studies Gender differences Heart surgery heart valve prosthesis implantation Hospital Mortality - trends Hospitals Humans Infections Male Morbidity - trends Mortality Prognosis Propensity Score Prospective Studies Prostheses Risk Assessment - methods risk factors Sex Distribution Sex Factors Sexes Spain - epidemiology Statistical analysis Surgical outcomes Survival Rate - trends Womens health |
| title | Analysis of sex differences in the clinical presentation, management and prognosis of infective endocarditis in Spain |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T07%3A27%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Analysis%20of%20sex%20differences%20in%20the%20clinical%20presentation,%20management%20and%20prognosis%20of%20infective%20endocarditis%20in%20Spain&rft.jtitle=Heart%20(British%20Cardiac%20Society)&rft.au=Varela%20Barca,%20Laura&rft.aucorp=GAMES%20Investigators&rft.date=2021-11-01&rft.volume=107&rft.issue=21&rft.spage=1717&rft.epage=1724&rft.pages=1717-1724&rft.issn=1355-6037&rft.eissn=1468-201X&rft_id=info:doi/10.1136/heartjnl-2021-319254&rft_dat=%3Cproquest_cross%3E2580848595%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2580848595&rft_id=info:pmid/34290038&rfr_iscdi=true |