A gated material as immunosensor for in-tissue detection of IDH1-R132H mutation in gliomas

[Display omitted] •The presence of IDH1-R132H mutated enzyme in gliomas has been related to a better prognosis.•Here is reported a nanodevice for the detection of IDH1-R132H mutant enzyme in human glioma tissue.•The nanodevice is based on NAA supports functionalized with antibody-based gatekeepers.•...

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Veröffentlicht in:	Sensors and actuators. B, Chemical Chemical, 2021-10, Vol.345, p.130406, Article 130406
Hauptverfasser:	Pla, Luis, Sancenón, Félix, Martínez-Bisbal, M. Carmen, Prat-Acín, Ricardo, Galeano-Senabre, Inmaculada, Botello-Marabotto, Marina, Palanca-Suela, Sarai, Aznar, Elena, Santiago-Felipe, Sara, Martínez-Máñez, Ramón
Format:	Artikel
Sprache:	eng
Schlagworte:	Aluminum oxide Antibodies Antibody Biosensors Decision making Enzymes Fluorescence Fluorometers Gated material Glioblastoma IDH1 Immunosensors Medical prognosis Mutation Nanoporous anodic alumina Nanotechnology devices Selectivity Sensitivity
Online-Zugang:	Volltext
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