Cerebral vessels reactivity disorders in microgravity and its pharmacological correction with new derivatives of 1,2,4- triazole

Objective: study of vascular reactivity disorders under the action of a pathological model of microgravity and study of the pharmacological effect of 1,2,4-triazole derivatives on the reactivity of the cerebral vessels of various structures of the brain when simulating circulatory disorders under the influence of a pathological model of microgravity. Methods: the anti-orthostatic position was used as a pathological model. A series of experiments was carried out with laboratory animals, which were previously implanted with platinum electrodes in various structures of the brain. Dilator reactivity of vessels to hypercapnia (CrCO2), and constrictor reactivity of blood vessels to hyperoxia (CrO2) were studied by the hydrogen clearance method. Investigated substances were injected into the marginal vein of the rabbit ear in a dose of 25 mg/kg just before the onset of the action of the experimental models. Results: new pharmacologically active substances reduce oppression of constrictor reactivity and dilator reactivity of vessels caused by head down tilting model (HDTM) in all studied structures of the brain. Conclusion: the investigated substances are interested for further study of their effects in correction of cerebral hemodynamic with decrease in gravity.