Emerging role of trimethylamine-N-oxide (TMAO) in colorectal cancer
Among gut microbiota-derived metabolites, trimethylamine-N-oxide (TMAO) is receiving increased attention due to its possible role in the carcinogenesis of colorectal cancer (CRC). In spite of numerous reports implicating TMAO with CRC, there is a lack of empirical mechanistic evidences to concretize...
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| Veröffentlicht in: | Applied microbiology and biotechnology 2021-10, Vol.105 (20), p.7651-7660 |
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| container_title | Applied microbiology and biotechnology |
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| creator | Jalandra, Rekha Dalal, Nishu Yadav, Amit K. Verma, Damini Sharma, Minakshi Singh, Rajeev Khosla, Ajit Kumar, Anil Solanki, Pratima R. |
| description | Among gut microbiota-derived metabolites, trimethylamine-N-oxide (TMAO) is receiving increased attention due to its possible role in the carcinogenesis of colorectal cancer (CRC). In spite of numerous reports implicating TMAO with CRC, there is a lack of empirical mechanistic evidences to concretize the involvement of TMAO in the carcinogenesis of CRC. Possible mechanisms such as inflammation, oxidative stress, DNA damage, and protein misfolding by TMAO have been discussed in this review in the light of the latest advancements in the field. This review is an attempt to discuss the probable correlation between TMAO and CRC but this linkage can be concretized only once we get sufficient empirical evidences from the mechanistic studies. We believe, this review will augment the understanding of linking TMAO with CRC and will motivate researchers to move towards mechanistic study for reinforcing the idea of implicating TMAO with CRC causation.
Key points
• TMAO is a gut bacterial metabolite which has been implicated in CRC in recent years.
• The valid mechanistic approach of CRC causation by TMAO is unknown.
• The article summarizes the possible mechanisms which need to be explored for validation. |
| doi_str_mv | 10.1007/s00253-021-11582-7 |
| format | Article |
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Key points
• TMAO is a gut bacterial metabolite which has been implicated in CRC in recent years.
• The valid mechanistic approach of CRC causation by TMAO is unknown.
• The article summarizes the possible mechanisms which need to be explored for validation.</description><identifier>ISSN: 0175-7598</identifier><identifier>EISSN: 1432-0614</identifier><identifier>DOI: 10.1007/s00253-021-11582-7</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Biomedical and Life Sciences ; Biotechnology ; Cancer ; Carcinogenesis ; Carcinogens ; Colorectal cancer ; Colorectal carcinoma ; Development and progression ; DNA damage ; Intestinal microflora ; Life Sciences ; Metabolites ; Microbial Genetics and Genomics ; Microbiology ; Microbiota ; Mini-Review ; Oxidative stress ; Protein folding ; Reviews ; Trimethylamine ; Trimethylamine-N-oxide</subject><ispartof>Applied microbiology and biotechnology, 2021-10, Vol.105 (20), p.7651-7660</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-71689487cc2d69e3a2f44048fa9e3077cc0573ca3cbf8031e8f1c669cd4343dc3</citedby><cites>FETCH-LOGICAL-c419t-71689487cc2d69e3a2f44048fa9e3077cc0573ca3cbf8031e8f1c669cd4343dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00253-021-11582-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00253-021-11582-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27907,27908,41471,42540,51302</link.rule.ids></links><search><creatorcontrib>Jalandra, Rekha</creatorcontrib><creatorcontrib>Dalal, Nishu</creatorcontrib><creatorcontrib>Yadav, Amit K.</creatorcontrib><creatorcontrib>Verma, Damini</creatorcontrib><creatorcontrib>Sharma, Minakshi</creatorcontrib><creatorcontrib>Singh, Rajeev</creatorcontrib><creatorcontrib>Khosla, Ajit</creatorcontrib><creatorcontrib>Kumar, Anil</creatorcontrib><creatorcontrib>Solanki, Pratima R.</creatorcontrib><title>Emerging role of trimethylamine-N-oxide (TMAO) in colorectal cancer</title><title>Applied microbiology and biotechnology</title><addtitle>Appl Microbiol Biotechnol</addtitle><description>Among gut microbiota-derived metabolites, trimethylamine-N-oxide (TMAO) is receiving increased attention due to its possible role in the carcinogenesis of colorectal cancer (CRC). In spite of numerous reports implicating TMAO with CRC, there is a lack of empirical mechanistic evidences to concretize the involvement of TMAO in the carcinogenesis of CRC. Possible mechanisms such as inflammation, oxidative stress, DNA damage, and protein misfolding by TMAO have been discussed in this review in the light of the latest advancements in the field. This review is an attempt to discuss the probable correlation between TMAO and CRC but this linkage can be concretized only once we get sufficient empirical evidences from the mechanistic studies. We believe, this review will augment the understanding of linking TMAO with CRC and will motivate researchers to move towards mechanistic study for reinforcing the idea of implicating TMAO with CRC causation.
Key points
• TMAO is a gut bacterial metabolite which has been implicated in CRC in recent years.
• The valid mechanistic approach of CRC causation by TMAO is unknown.
• The article summarizes the possible mechanisms which need to be explored for validation.</description><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Cancer</subject><subject>Carcinogenesis</subject><subject>Carcinogens</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Development and progression</subject><subject>DNA damage</subject><subject>Intestinal microflora</subject><subject>Life Sciences</subject><subject>Metabolites</subject><subject>Microbial Genetics and Genomics</subject><subject>Microbiology</subject><subject>Microbiota</subject><subject>Mini-Review</subject><subject>Oxidative stress</subject><subject>Protein 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role of trimethylamine-N-oxide (TMAO) in colorectal cancer</title><author>Jalandra, Rekha ; Dalal, Nishu ; Yadav, Amit K. ; Verma, Damini ; Sharma, Minakshi ; Singh, Rajeev ; Khosla, Ajit ; Kumar, Anil ; Solanki, Pratima R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-71689487cc2d69e3a2f44048fa9e3077cc0573ca3cbf8031e8f1c669cd4343dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Cancer</topic><topic>Carcinogenesis</topic><topic>Carcinogens</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Development and progression</topic><topic>DNA damage</topic><topic>Intestinal microflora</topic><topic>Life Sciences</topic><topic>Metabolites</topic><topic>Microbial Genetics and Genomics</topic><topic>Microbiology</topic><topic>Microbiota</topic><topic>Mini-Review</topic><topic>Oxidative stress</topic><topic>Protein folding</topic><topic>Reviews</topic><topic>Trimethylamine</topic><topic>Trimethylamine-N-oxide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jalandra, Rekha</creatorcontrib><creatorcontrib>Dalal, Nishu</creatorcontrib><creatorcontrib>Yadav, Amit K.</creatorcontrib><creatorcontrib>Verma, Damini</creatorcontrib><creatorcontrib>Sharma, Minakshi</creatorcontrib><creatorcontrib>Singh, Rajeev</creatorcontrib><creatorcontrib>Khosla, Ajit</creatorcontrib><creatorcontrib>Kumar, Anil</creatorcontrib><creatorcontrib>Solanki, Pratima R.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>ABI/INFORM 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biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jalandra, Rekha</au><au>Dalal, Nishu</au><au>Yadav, Amit K.</au><au>Verma, Damini</au><au>Sharma, Minakshi</au><au>Singh, Rajeev</au><au>Khosla, Ajit</au><au>Kumar, Anil</au><au>Solanki, Pratima R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Emerging role of trimethylamine-N-oxide (TMAO) in colorectal cancer</atitle><jtitle>Applied microbiology and biotechnology</jtitle><stitle>Appl Microbiol Biotechnol</stitle><date>2021-10-01</date><risdate>2021</risdate><volume>105</volume><issue>20</issue><spage>7651</spage><epage>7660</epage><pages>7651-7660</pages><issn>0175-7598</issn><eissn>1432-0614</eissn><abstract>Among gut microbiota-derived metabolites, trimethylamine-N-oxide (TMAO) is receiving increased attention due to its possible role in the carcinogenesis of colorectal cancer (CRC). In spite of numerous reports implicating TMAO with CRC, there is a lack of empirical mechanistic evidences to concretize the involvement of TMAO in the carcinogenesis of CRC. Possible mechanisms such as inflammation, oxidative stress, DNA damage, and protein misfolding by TMAO have been discussed in this review in the light of the latest advancements in the field. This review is an attempt to discuss the probable correlation between TMAO and CRC but this linkage can be concretized only once we get sufficient empirical evidences from the mechanistic studies. We believe, this review will augment the understanding of linking TMAO with CRC and will motivate researchers to move towards mechanistic study for reinforcing the idea of implicating TMAO with CRC causation.
Key points
• TMAO is a gut bacterial metabolite which has been implicated in CRC in recent years.
• The valid mechanistic approach of CRC causation by TMAO is unknown.
• The article summarizes the possible mechanisms which need to be explored for validation.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00253-021-11582-7</doi><tpages>10</tpages></addata></record> |
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| ispartof | Applied microbiology and biotechnology, 2021-10, Vol.105 (20), p.7651-7660 |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Biomedical and Life Sciences Biotechnology Cancer Carcinogenesis Carcinogens Colorectal cancer Colorectal carcinoma Development and progression DNA damage Intestinal microflora Life Sciences Metabolites Microbial Genetics and Genomics Microbiology Microbiota Mini-Review Oxidative stress Protein folding Reviews Trimethylamine Trimethylamine-N-oxide |
| title | Emerging role of trimethylamine-N-oxide (TMAO) in colorectal cancer |
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