Antibacterial activity and phytochemical characterisation of Saussurea gossypiphora D. Don
The study demonstrates that S. gossypiphora contain number of secondary metabolites such as steroids, tannins, flavonoids, phenolics, carbohydrates, saponins, and amino acids. Methanolic extract (MESG) of the plant contained highest quantity of phenolics, flavonoids and has greater antioxidant, anti...
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| Veröffentlicht in: | Archives of microbiology 2021-10, Vol.203 (8), p.5055-5065 |
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| creator | Mishra, Abhay Prakash Saklani, Sarla Parcha, Versha Nigam, Manisha Coutinho, Henrique D. M. |
| description | The study demonstrates that
S. gossypiphora
contain number of secondary metabolites such as steroids, tannins, flavonoids, phenolics, carbohydrates, saponins, and amino acids. Methanolic extract (MESG) of the plant contained highest quantity of phenolics, flavonoids and has greater antioxidant, anti-inflammatory and antibacterial activity in comparison to other extracts. Moreover, acute toxicity studies revealed that none of the extracts produced any toxic symptoms and mortality when administered orally to mice at a dose of 2000 mg/kg b. w. Furthermore, in MESG, the SG-4 fraction exhibited the highest antibacterial activity than other isolated fractions against all tested bacterial strains in a dose-dependent manner. SG-4 fraction showed significant anti-inflammatory effect (60.91%) as evident by maximum inhibition of Carrageenan-induced paw oedema in rat model. The HPTLC analysis confirmed the presence of apigenin and luteolin in the SG-4 fraction of methanolic extract. A noticeable number of mineral elements were also found to be present in
S. gossypiphora.
Conclusively, our study reveals that
Saussurea gossypiphora
contains plethora of bioactive compounds that contributes to its antioxidant, anti-inflammatory and antibacterial activity. Apigenin and luteolin possibly being one of them. Besides, the presence of ample minerals hints is utilisation as nutritionally valuable herb. |
| doi_str_mv | 10.1007/s00203-021-02494-1 |
| format | Article |
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S. gossypiphora
contain number of secondary metabolites such as steroids, tannins, flavonoids, phenolics, carbohydrates, saponins, and amino acids. Methanolic extract (MESG) of the plant contained highest quantity of phenolics, flavonoids and has greater antioxidant, anti-inflammatory and antibacterial activity in comparison to other extracts. Moreover, acute toxicity studies revealed that none of the extracts produced any toxic symptoms and mortality when administered orally to mice at a dose of 2000 mg/kg b. w. Furthermore, in MESG, the SG-4 fraction exhibited the highest antibacterial activity than other isolated fractions against all tested bacterial strains in a dose-dependent manner. SG-4 fraction showed significant anti-inflammatory effect (60.91%) as evident by maximum inhibition of Carrageenan-induced paw oedema in rat model. The HPTLC analysis confirmed the presence of apigenin and luteolin in the SG-4 fraction of methanolic extract. A noticeable number of mineral elements were also found to be present in
S. gossypiphora.
Conclusively, our study reveals that
Saussurea gossypiphora
contains plethora of bioactive compounds that contributes to its antioxidant, anti-inflammatory and antibacterial activity. Apigenin and luteolin possibly being one of them. Besides, the presence of ample minerals hints is utilisation as nutritionally valuable herb.</description><identifier>ISSN: 0302-8933</identifier><identifier>EISSN: 1432-072X</identifier><identifier>DOI: 10.1007/s00203-021-02494-1</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acute toxicity ; Amino acids ; Antibacterial activity ; Antioxidants ; Bioactive compounds ; Biochemistry ; Biocompatibility ; Biomedical and Life Sciences ; Biotechnology ; Carbohydrates ; Carrageenan ; Cell Biology ; Ecology ; Edema ; Flavonoids ; Inflammation ; Life Sciences ; Metabolites ; Microbial Ecology ; Microbiology ; Minerals ; Oral administration ; Original Paper ; Phenols ; Plant extracts ; Saponins ; Saussurea ; Secondary metabolites ; Steroid hormones ; Toxicity</subject><ispartof>Archives of microbiology, 2021-10, Vol.203 (8), p.5055-5065</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-649e0f4bbf657fd2f02d8215e365e5d017a826be17564e8d1805696903d240033</citedby><cites>FETCH-LOGICAL-c352t-649e0f4bbf657fd2f02d8215e365e5d017a826be17564e8d1805696903d240033</cites><orcidid>0000-0002-6634-4207</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00203-021-02494-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00203-021-02494-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids></links><search><creatorcontrib>Mishra, Abhay Prakash</creatorcontrib><creatorcontrib>Saklani, Sarla</creatorcontrib><creatorcontrib>Parcha, Versha</creatorcontrib><creatorcontrib>Nigam, Manisha</creatorcontrib><creatorcontrib>Coutinho, Henrique D. M.</creatorcontrib><title>Antibacterial activity and phytochemical characterisation of Saussurea gossypiphora D. Don</title><title>Archives of microbiology</title><addtitle>Arch Microbiol</addtitle><description>The study demonstrates that
S. gossypiphora
contain number of secondary metabolites such as steroids, tannins, flavonoids, phenolics, carbohydrates, saponins, and amino acids. Methanolic extract (MESG) of the plant contained highest quantity of phenolics, flavonoids and has greater antioxidant, anti-inflammatory and antibacterial activity in comparison to other extracts. Moreover, acute toxicity studies revealed that none of the extracts produced any toxic symptoms and mortality when administered orally to mice at a dose of 2000 mg/kg b. w. Furthermore, in MESG, the SG-4 fraction exhibited the highest antibacterial activity than other isolated fractions against all tested bacterial strains in a dose-dependent manner. SG-4 fraction showed significant anti-inflammatory effect (60.91%) as evident by maximum inhibition of Carrageenan-induced paw oedema in rat model. The HPTLC analysis confirmed the presence of apigenin and luteolin in the SG-4 fraction of methanolic extract. A noticeable number of mineral elements were also found to be present in
S. gossypiphora.
Conclusively, our study reveals that
Saussurea gossypiphora
contains plethora of bioactive compounds that contributes to its antioxidant, anti-inflammatory and antibacterial activity. Apigenin and luteolin possibly being one of them. Besides, the presence of ample minerals hints is utilisation as nutritionally valuable herb.</description><subject>Acute toxicity</subject><subject>Amino acids</subject><subject>Antibacterial activity</subject><subject>Antioxidants</subject><subject>Bioactive compounds</subject><subject>Biochemistry</subject><subject>Biocompatibility</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Carbohydrates</subject><subject>Carrageenan</subject><subject>Cell Biology</subject><subject>Ecology</subject><subject>Edema</subject><subject>Flavonoids</subject><subject>Inflammation</subject><subject>Life Sciences</subject><subject>Metabolites</subject><subject>Microbial Ecology</subject><subject>Microbiology</subject><subject>Minerals</subject><subject>Oral administration</subject><subject>Original Paper</subject><subject>Phenols</subject><subject>Plant extracts</subject><subject>Saponins</subject><subject>Saussurea</subject><subject>Secondary metabolites</subject><subject>Steroid hormones</subject><subject>Toxicity</subject><issn>0302-8933</issn><issn>1432-072X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kE9LxDAQxYMouK5-AU8Bz10nk6ZNj8uu_0DwoIJ4CWmbbrPsNjXpCv32Rit48zDMwLz3ZvgRcslgwQDy6wCAwBNAFist0oQdkRlLOSaQ49sxmQEHTGTB-Sk5C2ELwFBKOSPvy26wpa4G463e0TjYTzuMVHc17dtxcFVr9raKq6rVftIFPVjXUdfQZ30I4eCNphsXwtjbvnVe0_WCrl13Tk4avQvm4rfPyevtzcvqPnl8untYLR-TigsckiwtDDRpWTaZyJsaG8BaIhOGZ8KIGliuJWalYbnIUiNrJkFkRVYArzEF4HxOrqbc3ruPgwmD2rqD7-JJhUICz3NkRVThpKp8fNWbRvXe7rUfFQP1zVBNDFVkqH4YKhZNfDKFKO42xv9F_-P6Ap8IdBg</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Mishra, Abhay Prakash</creator><creator>Saklani, Sarla</creator><creator>Parcha, Versha</creator><creator>Nigam, Manisha</creator><creator>Coutinho, Henrique D. M.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><orcidid>https://orcid.org/0000-0002-6634-4207</orcidid></search><sort><creationdate>20211001</creationdate><title>Antibacterial activity and phytochemical characterisation of Saussurea gossypiphora D. Don</title><author>Mishra, Abhay Prakash ; Saklani, Sarla ; Parcha, Versha ; Nigam, Manisha ; Coutinho, Henrique D. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-649e0f4bbf657fd2f02d8215e365e5d017a826be17564e8d1805696903d240033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acute toxicity</topic><topic>Amino acids</topic><topic>Antibacterial activity</topic><topic>Antioxidants</topic><topic>Bioactive compounds</topic><topic>Biochemistry</topic><topic>Biocompatibility</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Carbohydrates</topic><topic>Carrageenan</topic><topic>Cell Biology</topic><topic>Ecology</topic><topic>Edema</topic><topic>Flavonoids</topic><topic>Inflammation</topic><topic>Life Sciences</topic><topic>Metabolites</topic><topic>Microbial Ecology</topic><topic>Microbiology</topic><topic>Minerals</topic><topic>Oral administration</topic><topic>Original Paper</topic><topic>Phenols</topic><topic>Plant extracts</topic><topic>Saponins</topic><topic>Saussurea</topic><topic>Secondary metabolites</topic><topic>Steroid hormones</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mishra, Abhay Prakash</creatorcontrib><creatorcontrib>Saklani, Sarla</creatorcontrib><creatorcontrib>Parcha, Versha</creatorcontrib><creatorcontrib>Nigam, Manisha</creatorcontrib><creatorcontrib>Coutinho, Henrique D. 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M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibacterial activity and phytochemical characterisation of Saussurea gossypiphora D. Don</atitle><jtitle>Archives of microbiology</jtitle><stitle>Arch Microbiol</stitle><date>2021-10-01</date><risdate>2021</risdate><volume>203</volume><issue>8</issue><spage>5055</spage><epage>5065</epage><pages>5055-5065</pages><issn>0302-8933</issn><eissn>1432-072X</eissn><abstract>The study demonstrates that
S. gossypiphora
contain number of secondary metabolites such as steroids, tannins, flavonoids, phenolics, carbohydrates, saponins, and amino acids. Methanolic extract (MESG) of the plant contained highest quantity of phenolics, flavonoids and has greater antioxidant, anti-inflammatory and antibacterial activity in comparison to other extracts. Moreover, acute toxicity studies revealed that none of the extracts produced any toxic symptoms and mortality when administered orally to mice at a dose of 2000 mg/kg b. w. Furthermore, in MESG, the SG-4 fraction exhibited the highest antibacterial activity than other isolated fractions against all tested bacterial strains in a dose-dependent manner. SG-4 fraction showed significant anti-inflammatory effect (60.91%) as evident by maximum inhibition of Carrageenan-induced paw oedema in rat model. The HPTLC analysis confirmed the presence of apigenin and luteolin in the SG-4 fraction of methanolic extract. A noticeable number of mineral elements were also found to be present in
S. gossypiphora.
Conclusively, our study reveals that
Saussurea gossypiphora
contains plethora of bioactive compounds that contributes to its antioxidant, anti-inflammatory and antibacterial activity. Apigenin and luteolin possibly being one of them. Besides, the presence of ample minerals hints is utilisation as nutritionally valuable herb.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00203-021-02494-1</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-6634-4207</orcidid></addata></record> |
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| subjects | Acute toxicity Amino acids Antibacterial activity Antioxidants Bioactive compounds Biochemistry Biocompatibility Biomedical and Life Sciences Biotechnology Carbohydrates Carrageenan Cell Biology Ecology Edema Flavonoids Inflammation Life Sciences Metabolites Microbial Ecology Microbiology Minerals Oral administration Original Paper Phenols Plant extracts Saponins Saussurea Secondary metabolites Steroid hormones Toxicity |
| title | Antibacterial activity and phytochemical characterisation of Saussurea gossypiphora D. Don |
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