F. nucleatum targets lncRNA ENO1-IT1 to promote glycolysis and oncogenesis in colorectal cancer

ObjectiveMicrobiota disorder promotes chronic inflammation and carcinogenesis. High glycolysis is associated with poor prognosis in patients with colorectal cancer (CRC). However, the potential correlation between the gut microbiota and glucose metabolism is unknown in CRC.Design 18F-FDG (18F-fluoro...

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Veröffentlicht in:	Gut 2021-11, Vol.70 (11), p.2123-2137
Hauptverfasser:	Hong, Jie, Guo, Fangfang, Lu, Shi-Yuan, Shen, Chaoqin, Ma, Dan, Zhang, Xinyu, Xie, Yile, Yan, Tingting, Yu, TaChung, Sun, Tiantian, Qian, Yun, Zhong, Ming, Chen, Jinxian, Peng, Yanshen, Wang, Cheng, Zhou, Xiang, Liu, Jianjun, Liu, Qiang, Ma, Xiong, Chen, Ying-Xuan, Chen, Haoyan, Fang, Jing-Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers, Tumor Cancer Carcinogenesis Carcinogenesis - genetics Cell growth Chromatin Colon Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - diagnostic imaging Colorectal Neoplasms - genetics DNA-Binding Proteins Drug resistance Fluorodeoxyglucose F18 - pharmacokinetics Fusobacterium Infections - genetics Fusobacterium nucleatum Gastrointestinal Microbiome Gene Expression Regulation, Neoplastic Glucose metabolism Glycolysis Glycolysis - genetics Histone acetyltransferase Histone Acetyltransferases Humans Immunoprecipitation intestinal bacteria Intestinal microflora Medical imaging Metabolites Mice Microbiota Non-coding RNA Patients Phosphopyruvate Hydratase Positron emission tomography Positron Emission Tomography Computed Tomography Prognosis Radiopharmaceuticals - pharmacokinetics RNA, Long Noncoding - genetics Signal Transduction Sp1 protein Tumor Cells, Cultured Tumor Suppressor Proteins Tumorigenesis
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