Development of functional gold nanorods for bioimaging and photothermal therapy
Gold nanorods have strong surface plasmon band at near-infrared light region, and are used as a photothermal converter. Since the near-infrared light penetrates into tissues deeply, it has been expected as a contrast agent for near infrared light bioimaging, a photosensitizer for photothermal therap...
Gespeichert in:
| Veröffentlicht in: | Journal of physics. Conference series 2010-06, Vol.232 (1), p.012011 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 1 |
| container_start_page | 012011 |
| container_title | Journal of physics. Conference series |
| container_volume | 232 |
| creator | Niidome, T |
| description | Gold nanorods have strong surface plasmon band at near-infrared light region, and are used as a photothermal converter. Since the near-infrared light penetrates into tissues deeply, it has been expected as a contrast agent for near infrared light bioimaging, a photosensitizer for photothermal therapy, and functional device for drug delivery system responding to near-infrared light irradiation. In this study, the surface plasmon bands of intravenously injected gold nanorods were monitored in the mouse abdomen using a spectrophotometer equipped with an integrating sphere, then we determined pharmacokinetics parameters of the gold nanorods after intravenous injection. Next, the PEG-modified gold nanorods were directly injected into subcutaneous tumors in mice, then, near-infrared pulsed laser light was irradiated the tumors. Significant tumor damage and suppression of the tumor growth was observed. We constructed targeted delivery system of the gold nanorods by modifying with a thermo-responsive polymer and a peptide responding to a protease activity. These modified gold nanorods are expected as functional nanodevices for photothermal therapy and drug delivery system. |
| doi_str_mv | 10.1088/1742-6596/232/1/012011 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_O3W</sourceid><recordid>TN_cdi_proquest_journals_2580052395</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2580052395</sourcerecordid><originalsourceid>FETCH-LOGICAL-c411t-b79c0e952dfaccb37963a6fee97240a9da541af2068bfcab84c6e628623775be3</originalsourceid><addsrcrecordid>eNqNkE1LxDAQhoMouK7-BQl4rs1HkzZHWT9hYS96DmmadLt0k5p0hf33plTEwx6cyzsw7zvMPADcYnSPUVXluCxIxpngOaEkxznCBGF8Bha_g_M__SW4inGHEE1VLsDm0XyZ3g9740boLbQHp8fOO9XD1vcNdMr54JsIrQ-w7ny3V23nWqhcA4etH_24NWGf3JOq4XgNLqzqo7n50SX4eH56X71m683L2-phnekC4zGrS6GREYw0Vmld01Jwqrg1RpSkQEo0ihVYWYJ4VVut6qrQ3HBScULLktWGLsHdvHcI_vNg4ih3_hDS2VESViHECBUsufjs0sHHGIyVQ0gfhKPESE7w5MRFTlxkgiexnOGlIJ6DnR_-n8lOZE565dBY-g0MvX8n</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2580052395</pqid></control><display><type>article</type><title>Development of functional gold nanorods for bioimaging and photothermal therapy</title><source>IOP Publishing Free Content</source><creator>Niidome, T</creator><creatorcontrib>Niidome, T</creatorcontrib><description>Gold nanorods have strong surface plasmon band at near-infrared light region, and are used as a photothermal converter. Since the near-infrared light penetrates into tissues deeply, it has been expected as a contrast agent for near infrared light bioimaging, a photosensitizer for photothermal therapy, and functional device for drug delivery system responding to near-infrared light irradiation. In this study, the surface plasmon bands of intravenously injected gold nanorods were monitored in the mouse abdomen using a spectrophotometer equipped with an integrating sphere, then we determined pharmacokinetics parameters of the gold nanorods after intravenous injection. Next, the PEG-modified gold nanorods were directly injected into subcutaneous tumors in mice, then, near-infrared pulsed laser light was irradiated the tumors. Significant tumor damage and suppression of the tumor growth was observed. We constructed targeted delivery system of the gold nanorods by modifying with a thermo-responsive polymer and a peptide responding to a protease activity. These modified gold nanorods are expected as functional nanodevices for photothermal therapy and drug delivery system.</description><identifier>ISSN: 1742-6596</identifier><identifier>ISSN: 1742-6588</identifier><identifier>EISSN: 1742-6596</identifier><identifier>DOI: 10.1088/1742-6596/232/1/012011</identifier><language>eng</language><publisher>Bristol: IOP Publishing</publisher><subject>Contrast agents ; Converters ; Drug delivery systems ; Gold ; Infrared lasers ; Infrared radiation ; Light irradiation ; Medical imaging ; Nanorods ; Nanotechnology devices ; Parameter modification ; Physics ; Pulsed lasers ; Radiation damage ; Therapy ; Tumors</subject><ispartof>Journal of physics. Conference series, 2010-06, Vol.232 (1), p.012011</ispartof><rights>Copyright IOP Publishing Jun 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-b79c0e952dfaccb37963a6fee97240a9da541af2068bfcab84c6e628623775be3</citedby><cites>FETCH-LOGICAL-c411t-b79c0e952dfaccb37963a6fee97240a9da541af2068bfcab84c6e628623775be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://iopscience.iop.org/article/10.1088/1742-6596/232/1/012011/pdf$$EPDF$$P50$$Giop$$H</linktopdf><link.rule.ids>314,776,780,1547,27607,27903,27904,53883,53910</link.rule.ids><linktorsrc>$$Uhttp://iopscience.iop.org/1742-6596/232/1/012011$$EView_record_in_IOP_Publishing$$FView_record_in_$$GIOP_Publishing</linktorsrc></links><search><creatorcontrib>Niidome, T</creatorcontrib><title>Development of functional gold nanorods for bioimaging and photothermal therapy</title><title>Journal of physics. Conference series</title><description>Gold nanorods have strong surface plasmon band at near-infrared light region, and are used as a photothermal converter. Since the near-infrared light penetrates into tissues deeply, it has been expected as a contrast agent for near infrared light bioimaging, a photosensitizer for photothermal therapy, and functional device for drug delivery system responding to near-infrared light irradiation. In this study, the surface plasmon bands of intravenously injected gold nanorods were monitored in the mouse abdomen using a spectrophotometer equipped with an integrating sphere, then we determined pharmacokinetics parameters of the gold nanorods after intravenous injection. Next, the PEG-modified gold nanorods were directly injected into subcutaneous tumors in mice, then, near-infrared pulsed laser light was irradiated the tumors. Significant tumor damage and suppression of the tumor growth was observed. We constructed targeted delivery system of the gold nanorods by modifying with a thermo-responsive polymer and a peptide responding to a protease activity. These modified gold nanorods are expected as functional nanodevices for photothermal therapy and drug delivery system.</description><subject>Contrast agents</subject><subject>Converters</subject><subject>Drug delivery systems</subject><subject>Gold</subject><subject>Infrared lasers</subject><subject>Infrared radiation</subject><subject>Light irradiation</subject><subject>Medical imaging</subject><subject>Nanorods</subject><subject>Nanotechnology devices</subject><subject>Parameter modification</subject><subject>Physics</subject><subject>Pulsed lasers</subject><subject>Radiation damage</subject><subject>Therapy</subject><subject>Tumors</subject><issn>1742-6596</issn><issn>1742-6588</issn><issn>1742-6596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqNkE1LxDAQhoMouK7-BQl4rs1HkzZHWT9hYS96DmmadLt0k5p0hf33plTEwx6cyzsw7zvMPADcYnSPUVXluCxIxpngOaEkxznCBGF8Bha_g_M__SW4inGHEE1VLsDm0XyZ3g9740boLbQHp8fOO9XD1vcNdMr54JsIrQ-w7ny3V23nWqhcA4etH_24NWGf3JOq4XgNLqzqo7n50SX4eH56X71m683L2-phnekC4zGrS6GREYw0Vmld01Jwqrg1RpSkQEo0ihVYWYJ4VVut6qrQ3HBScULLktWGLsHdvHcI_vNg4ih3_hDS2VESViHECBUsufjs0sHHGIyVQ0gfhKPESE7w5MRFTlxkgiexnOGlIJ6DnR_-n8lOZE565dBY-g0MvX8n</recordid><startdate>20100601</startdate><enddate>20100601</enddate><creator>Niidome, T</creator><general>IOP Publishing</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>H8D</scope><scope>HCIFZ</scope><scope>L7M</scope><scope>P5Z</scope><scope>P62</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20100601</creationdate><title>Development of functional gold nanorods for bioimaging and photothermal therapy</title><author>Niidome, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-b79c0e952dfaccb37963a6fee97240a9da541af2068bfcab84c6e628623775be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Contrast agents</topic><topic>Converters</topic><topic>Drug delivery systems</topic><topic>Gold</topic><topic>Infrared lasers</topic><topic>Infrared radiation</topic><topic>Light irradiation</topic><topic>Medical imaging</topic><topic>Nanorods</topic><topic>Nanotechnology devices</topic><topic>Parameter modification</topic><topic>Physics</topic><topic>Pulsed lasers</topic><topic>Radiation damage</topic><topic>Therapy</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Niidome, T</creatorcontrib><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Aerospace Database</collection><collection>SciTech Premium Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Journal of physics. Conference series</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Niidome, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of functional gold nanorods for bioimaging and photothermal therapy</atitle><jtitle>Journal of physics. Conference series</jtitle><date>2010-06-01</date><risdate>2010</risdate><volume>232</volume><issue>1</issue><spage>012011</spage><pages>012011-</pages><issn>1742-6596</issn><issn>1742-6588</issn><eissn>1742-6596</eissn><abstract>Gold nanorods have strong surface plasmon band at near-infrared light region, and are used as a photothermal converter. Since the near-infrared light penetrates into tissues deeply, it has been expected as a contrast agent for near infrared light bioimaging, a photosensitizer for photothermal therapy, and functional device for drug delivery system responding to near-infrared light irradiation. In this study, the surface plasmon bands of intravenously injected gold nanorods were monitored in the mouse abdomen using a spectrophotometer equipped with an integrating sphere, then we determined pharmacokinetics parameters of the gold nanorods after intravenous injection. Next, the PEG-modified gold nanorods were directly injected into subcutaneous tumors in mice, then, near-infrared pulsed laser light was irradiated the tumors. Significant tumor damage and suppression of the tumor growth was observed. We constructed targeted delivery system of the gold nanorods by modifying with a thermo-responsive polymer and a peptide responding to a protease activity. These modified gold nanorods are expected as functional nanodevices for photothermal therapy and drug delivery system.</abstract><cop>Bristol</cop><pub>IOP Publishing</pub><doi>10.1088/1742-6596/232/1/012011</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 1742-6596 |
| ispartof | Journal of physics. Conference series, 2010-06, Vol.232 (1), p.012011 |
| issn | 1742-6596 1742-6588 1742-6596 |
| language | eng |
| recordid | cdi_proquest_journals_2580052395 |
| source | IOP Publishing Free Content |
| subjects | Contrast agents Converters Drug delivery systems Gold Infrared lasers Infrared radiation Light irradiation Medical imaging Nanorods Nanotechnology devices Parameter modification Physics Pulsed lasers Radiation damage Therapy Tumors |
| title | Development of functional gold nanorods for bioimaging and photothermal therapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T14%3A01%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_O3W&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Development%20of%20functional%20gold%20nanorods%20for%20bioimaging%20and%20photothermal%20therapy&rft.jtitle=Journal%20of%20physics.%20Conference%20series&rft.au=Niidome,%20T&rft.date=2010-06-01&rft.volume=232&rft.issue=1&rft.spage=012011&rft.pages=012011-&rft.issn=1742-6596&rft.eissn=1742-6596&rft_id=info:doi/10.1088/1742-6596/232/1/012011&rft_dat=%3Cproquest_O3W%3E2580052395%3C/proquest_O3W%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2580052395&rft_id=info:pmid/&rfr_iscdi=true |