Fabrication of bone-targeting hyaluronic acid coupled alendronate-bioactive glass for osteosarcoma therapy

Osteosarcoma is a complicated clinical cancer for patients, which seriously reduces the quality of life. The current conventional treatment is focused on controlling cancer cell proliferation and osteoclast activity. The aim is to develop mesoporous bioactive glass (MBG) with bone-targeting hyaluron...

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Veröffentlicht in:	Materials chemistry and physics 2021-11, Vol.273, p.125146, Article 125146
Hauptverfasser:	Mehnath, Sivaraj, Karthikeyan, Kandhasamy, Rajan, Mariappan, Jeyaraj, Murugaraj
Format:	Artikel
Sprache:	eng
Schlagworte:	Alendronate Biocompatibility Bioglass Biological activity Biomedical materials Bone cancer Bone targeting Cancer Ceramic composites Coating effects Hyaluronic acid Hydroxyapatite Mesoporous bioactive glass Morphology Nanocomposites Nanoparticles Osteointegration Osteosarcoma Regeneration Tissue engineering Toxicity
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