Fluorescence resonance energy transfer-based screening for protein kinase C ligands using 6-methoxynaphthalene-labeled 1,2-diacylglycerol-lactones

Protein kinase C (PKC) is associated with a central cellular signal transduction pathway and disorders such as cancer and Alzheimer-type dementia and is therefore a target for the treatment of these diseases. The development of simple methods suitable for high-throughput screening to find potent PKC...

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Veröffentlicht in:	Organic & biomolecular chemistry 2021-10, Vol.19 (38), p.8264-8271
Hauptverfasser:	Tsuji, Kohei, Ishii, Takahiro, Kobayakawa, Takuya, Ohashi, Nami, Nomura, Wataru, Tamamura, Hirokazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Assaying Binding Dementia disorders Diglycerides Diglycerides - chemistry Diglycerides - metabolism Domains Drug Evaluation, Preclinical Dyes Energy transfer Fluorescein Fluorescence Fluorescence Resonance Energy Transfer Fluorescent dyes Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Fluorescent indicators High-throughput screening Humans Kinases Lactones Lactones - chemistry Lactones - metabolism Ligands Methoxynaphthalene Molecular Structure Naphthalenes - chemical synthesis Naphthalenes - chemistry Naphthalenes - metabolism Protein kinase C Protein Kinase C - chemistry Protein Kinase C - metabolism Proteins Radioisotopes Resonance Screening Signal transduction
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