Functional connectivity within an anxiety network and associations with anxiety symptom severity in middle‐aged adults with and without autism
Anxiety is highly prevalent in autism spectrum disorders (ASDs). However, few functional magnetic resonance imaging (fMRI) studies of ASDs have focused on anxiety (and fewer still on anxiety in middle‐aged adults). Thus, relationships between atypical connectivity and anxiety in this population are...
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| Veröffentlicht in: | Autism research 2021-10, Vol.14 (10), p.2100-2112 |
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| creator | Tung, Ryan Reiter, Maya A. Linke, Annika Kohli, Jiwandeep S. Kinnear, Mikaela K. Müller, Ralph‐Axel Carper, Ruth A. |
| description | Anxiety is highly prevalent in autism spectrum disorders (ASDs). However, few functional magnetic resonance imaging (fMRI) studies of ASDs have focused on anxiety (and fewer still on anxiety in middle‐aged adults). Thus, relationships between atypical connectivity and anxiety in this population are poorly understood. The current study contrasted functional connectivity within anxiety network regions across adults (40–64 years) with and without autism, and tested for group by functional connectivity interactions on anxiety. Twenty‐two adults with ASDs (16 males) and 26 typical control (TC) adults (22 males) completed the Beck Anxiety Inventory and a resting‐state fMRI scan. An anxiety network consisting of 12 regions of interest was defined, based on a meta‐analysis in TC individuals and two studies on anxiety in ASDs. We tested for main effects of group and group by anxiety interactions on connectivity within this anxiety network, controlling for head motion using ANCOVA. Results are reported at an FDR adjusted threshold of q |
| doi_str_mv | 10.1002/aur.2579 |
| format | Article |
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Lay Summary
Anxiety is very common in adults with autism but the brain basis of this difference is not well understood. We compared functional connectivity between anxiety‐related brain regions in middle‐aged adults with and without autism. Adults with autism were more anxious and showed weaker functional connections between these regions. Some relationships between functional connectivity and higher anxiety were specific to the autism group. Results suggest that anxiety functions differently in autism.</description><identifier>ISSN: 1939-3792</identifier><identifier>EISSN: 1939-3806</identifier><identifier>DOI: 10.1002/aur.2579</identifier><identifier>PMID: 34264028</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Adults ; Anxiety ; ASD ; Autism ; Behavioral Sciences ; Brain ; Brain mapping ; Brain research ; functional connectivity ; Functional magnetic resonance imaging ; Head movement ; Life Sciences & Biomedicine ; Magnetic resonance imaging ; Middle age ; Neural networks ; Neuroimaging ; Psychology ; Psychology, Developmental ; resting state fMRI ; Science & Technology ; Signs and symptoms ; Social Sciences</subject><ispartof>Autism research, 2021-10, Vol.14 (10), p.2100-2112</ispartof><rights>2021 International Society for Autism Research, Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>2</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000673568000001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c4159-7ea746f38f11af8016cdbfe8412ecba5129d671edee2e6e06d5edd68332d2e443</citedby><cites>FETCH-LOGICAL-c4159-7ea746f38f11af8016cdbfe8412ecba5129d671edee2e6e06d5edd68332d2e443</cites><orcidid>0000-0001-7299-6757 ; 0000-0002-1195-5473 ; 0000-0003-3119-7718</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Faur.2579$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Faur.2579$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,315,781,785,886,1418,27929,27930,39262,39263,45579,45580</link.rule.ids></links><search><creatorcontrib>Tung, Ryan</creatorcontrib><creatorcontrib>Reiter, Maya A.</creatorcontrib><creatorcontrib>Linke, Annika</creatorcontrib><creatorcontrib>Kohli, Jiwandeep S.</creatorcontrib><creatorcontrib>Kinnear, Mikaela K.</creatorcontrib><creatorcontrib>Müller, Ralph‐Axel</creatorcontrib><creatorcontrib>Carper, Ruth A.</creatorcontrib><title>Functional connectivity within an anxiety network and associations with anxiety symptom severity in middle‐aged adults with and without autism</title><title>Autism research</title><addtitle>AUTISM RES</addtitle><description>Anxiety is highly prevalent in autism spectrum disorders (ASDs). However, few functional magnetic resonance imaging (fMRI) studies of ASDs have focused on anxiety (and fewer still on anxiety in middle‐aged adults). Thus, relationships between atypical connectivity and anxiety in this population are poorly understood. The current study contrasted functional connectivity within anxiety network regions across adults (40–64 years) with and without autism, and tested for group by functional connectivity interactions on anxiety. Twenty‐two adults with ASDs (16 males) and 26 typical control (TC) adults (22 males) completed the Beck Anxiety Inventory and a resting‐state fMRI scan. An anxiety network consisting of 12 regions of interest was defined, based on a meta‐analysis in TC individuals and two studies on anxiety in ASDs. We tested for main effects of group and group by anxiety interactions on connectivity within this anxiety network, controlling for head motion using ANCOVA. Results are reported at an FDR adjusted threshold of q < 0.1 (corrected) and p < 0.05 (uncorrected). Adults with ASDs showed higher anxiety and underconnectivity within the anxiety network, mostly involving bilateral insula. Connectivity within the anxiety network in the ASD group showed distinct relationships with anxiety symptoms that did not relate to ASD symptom severity. Functional connectivity involving the bilateral posterior insula was positively correlated with anxiety in the ASD (but not the TC) group. Increased anxiety in middle‐aged adults with ASD is associated with atypical functional connectivity, predominantly involving bilateral insula. Results were not related to ASD symptom severity suggesting independence of anxiety‐related effects.
Lay Summary
Anxiety is very common in adults with autism but the brain basis of this difference is not well understood. We compared functional connectivity between anxiety‐related brain regions in middle‐aged adults with and without autism. Adults with autism were more anxious and showed weaker functional connections between these regions. Some relationships between functional connectivity and higher anxiety were specific to the autism group. Results suggest that anxiety functions differently in autism.</description><subject>Adults</subject><subject>Anxiety</subject><subject>ASD</subject><subject>Autism</subject><subject>Behavioral Sciences</subject><subject>Brain</subject><subject>Brain mapping</subject><subject>Brain research</subject><subject>functional connectivity</subject><subject>Functional magnetic resonance imaging</subject><subject>Head movement</subject><subject>Life Sciences & Biomedicine</subject><subject>Magnetic resonance imaging</subject><subject>Middle age</subject><subject>Neural networks</subject><subject>Neuroimaging</subject><subject>Psychology</subject><subject>Psychology, Developmental</subject><subject>resting state fMRI</subject><subject>Science & Technology</subject><subject>Signs and symptoms</subject><subject>Social Sciences</subject><issn>1939-3792</issn><issn>1939-3806</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>GIZIO</sourceid><sourceid>HGBXW</sourceid><recordid>eNqNkd1qFDEYhgdR7I-ClzDgiSBT8zPJZE6EslgVCoLY45BNvmlTZ5I1P7vumZfQa_RKmtmuKwqCISFfkud9-chbVS8wOsMIkTcqhzPCuv5RdYx72jdUIP74V9315Kg6ifEWIY4oI0-rI9oS3iIijqu7i-x0st6psdbeOSiHtU3bemPTjXW1mud3C-XGQdr48LWcTa1i9NqqWRh36IGK22mV_FRHWEOYjYrJZI0Z4eePO3UNRWvymA4qsyt8TrXKycbpWfVkUGOE5_v9tLq6ePdl8aG5_PT-4-L8stEtZn3TgepaPlAxYKwGgTDXZjmAaDEBvVQMk97wDoMBIMABccPAGC4oJYZA29LT6u2D7yovJzAaXApqlKtgJxW20isr_3xx9kZe-7UUrej6DhWDV3uD4L9liElONmoYR-XA5ygJYwSVJUhBX_6F3vocypfPVCco6hklvw118DEGGA7NYCTnmGWJeRb0BRUP6AaWfojagtNwwFEJuqOMCzQPvLBpF9TCZ5eK9PX_Swvd7Gk7wvafDcnzq8-7xu4B55XOjw</recordid><startdate>202110</startdate><enddate>202110</enddate><creator>Tung, Ryan</creator><creator>Reiter, Maya A.</creator><creator>Linke, Annika</creator><creator>Kohli, Jiwandeep S.</creator><creator>Kinnear, Mikaela K.</creator><creator>Müller, Ralph‐Axel</creator><creator>Carper, Ruth A.</creator><general>John Wiley & Sons, Inc</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>17B</scope><scope>BLEPL</scope><scope>DTL</scope><scope>DVR</scope><scope>EGQ</scope><scope>GIZIO</scope><scope>HGBXW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7299-6757</orcidid><orcidid>https://orcid.org/0000-0002-1195-5473</orcidid><orcidid>https://orcid.org/0000-0003-3119-7718</orcidid></search><sort><creationdate>202110</creationdate><title>Functional connectivity within an anxiety network and associations with anxiety symptom severity in middle‐aged adults with and without autism</title><author>Tung, Ryan ; Reiter, Maya A. ; Linke, Annika ; Kohli, Jiwandeep S. ; Kinnear, Mikaela K. ; Müller, Ralph‐Axel ; Carper, Ruth A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4159-7ea746f38f11af8016cdbfe8412ecba5129d671edee2e6e06d5edd68332d2e443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adults</topic><topic>Anxiety</topic><topic>ASD</topic><topic>Autism</topic><topic>Behavioral Sciences</topic><topic>Brain</topic><topic>Brain mapping</topic><topic>Brain research</topic><topic>functional connectivity</topic><topic>Functional magnetic resonance imaging</topic><topic>Head movement</topic><topic>Life Sciences & Biomedicine</topic><topic>Magnetic resonance imaging</topic><topic>Middle age</topic><topic>Neural networks</topic><topic>Neuroimaging</topic><topic>Psychology</topic><topic>Psychology, Developmental</topic><topic>resting state fMRI</topic><topic>Science & Technology</topic><topic>Signs and symptoms</topic><topic>Social Sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tung, Ryan</creatorcontrib><creatorcontrib>Reiter, Maya A.</creatorcontrib><creatorcontrib>Linke, Annika</creatorcontrib><creatorcontrib>Kohli, Jiwandeep S.</creatorcontrib><creatorcontrib>Kinnear, Mikaela K.</creatorcontrib><creatorcontrib>Müller, Ralph‐Axel</creatorcontrib><creatorcontrib>Carper, Ruth A.</creatorcontrib><collection>Web of Knowledge</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Social Sciences Citation Index</collection><collection>Web of Science Primary (SCIE, SSCI & AHCI)</collection><collection>Web of Science - Social Sciences Citation Index – 2021</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Autism research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tung, Ryan</au><au>Reiter, Maya A.</au><au>Linke, Annika</au><au>Kohli, Jiwandeep S.</au><au>Kinnear, Mikaela K.</au><au>Müller, Ralph‐Axel</au><au>Carper, Ruth A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional connectivity within an anxiety network and associations with anxiety symptom severity in middle‐aged adults with and without autism</atitle><jtitle>Autism research</jtitle><stitle>AUTISM RES</stitle><date>2021-10</date><risdate>2021</risdate><volume>14</volume><issue>10</issue><spage>2100</spage><epage>2112</epage><pages>2100-2112</pages><issn>1939-3792</issn><eissn>1939-3806</eissn><abstract>Anxiety is highly prevalent in autism spectrum disorders (ASDs). However, few functional magnetic resonance imaging (fMRI) studies of ASDs have focused on anxiety (and fewer still on anxiety in middle‐aged adults). Thus, relationships between atypical connectivity and anxiety in this population are poorly understood. The current study contrasted functional connectivity within anxiety network regions across adults (40–64 years) with and without autism, and tested for group by functional connectivity interactions on anxiety. Twenty‐two adults with ASDs (16 males) and 26 typical control (TC) adults (22 males) completed the Beck Anxiety Inventory and a resting‐state fMRI scan. An anxiety network consisting of 12 regions of interest was defined, based on a meta‐analysis in TC individuals and two studies on anxiety in ASDs. We tested for main effects of group and group by anxiety interactions on connectivity within this anxiety network, controlling for head motion using ANCOVA. Results are reported at an FDR adjusted threshold of q < 0.1 (corrected) and p < 0.05 (uncorrected). Adults with ASDs showed higher anxiety and underconnectivity within the anxiety network, mostly involving bilateral insula. Connectivity within the anxiety network in the ASD group showed distinct relationships with anxiety symptoms that did not relate to ASD symptom severity. Functional connectivity involving the bilateral posterior insula was positively correlated with anxiety in the ASD (but not the TC) group. Increased anxiety in middle‐aged adults with ASD is associated with atypical functional connectivity, predominantly involving bilateral insula. Results were not related to ASD symptom severity suggesting independence of anxiety‐related effects.
Lay Summary
Anxiety is very common in adults with autism but the brain basis of this difference is not well understood. We compared functional connectivity between anxiety‐related brain regions in middle‐aged adults with and without autism. Adults with autism were more anxious and showed weaker functional connections between these regions. Some relationships between functional connectivity and higher anxiety were specific to the autism group. Results suggest that anxiety functions differently in autism.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>34264028</pmid><doi>10.1002/aur.2579</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-7299-6757</orcidid><orcidid>https://orcid.org/0000-0002-1195-5473</orcidid><orcidid>https://orcid.org/0000-0003-3119-7718</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adults Anxiety ASD Autism Behavioral Sciences Brain Brain mapping Brain research functional connectivity Functional magnetic resonance imaging Head movement Life Sciences & Biomedicine Magnetic resonance imaging Middle age Neural networks Neuroimaging Psychology Psychology, Developmental resting state fMRI Science & Technology Signs and symptoms Social Sciences |
| title | Functional connectivity within an anxiety network and associations with anxiety symptom severity in middle‐aged adults with and without autism |
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