Inflammation suppression in doxorubicin-induced cardiotoxicity: natural compounds as therapeutic options

Doxorubicin (DOX) is a potent chemotherapeutic agent; however, the accompanying cardiotoxicity is a significant complication of the usefulness of treatment with DOX. Multiple mechanisms have been suggested for this often fatal side effect, one of which is inflammation. Several pathways with differen...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2021-10, Vol.394 (10), p.2003-2011
Hauptverfasser:	Yarmohammadi, Fatemeh, Karbasforooshan, Hedyieh, Hayes, A. Wallace, Karimi, Gholamreza
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - therapeutic use Antibiotics, Antineoplastic - adverse effects Apoptosis Biological Products - therapeutic use Biomedical and Life Sciences Biomedicine Cardiomyocytes Cardiotoxicity Cardiotoxicity - drug therapy Cytokines Doxorubicin Doxorubicin - adverse effects Heart Inflammasomes Inflammation Kinases MAP kinase Neurosciences NF-κB protein Pharmacology/Toxicology Pharmacy Proteins Review Toxicology Tumor necrosis factor-TNF
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