Synthesis and structure confirmation of 7‐ester‐8‐aminomethylene‐substituted baicalein derivatives

Twelve baicalein derivatives, derivatized with 7‐ester and 8‐aminomethylene groups, were synthesized as cyclin‐dependent kinase 1 (CDK1) inhibitors, by the addition of one of four secondary amines to C‐8, using the Mannich reaction, followed by mono‐esterification with one of three carboxylic acids....

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Veröffentlicht in:	Journal of the Chinese Chemical Society (Taipei) 2021-09, Vol.68 (9), p.1598-1603
Hauptverfasser:	Mou, Jiajia, Wang, Qiang, Deng, Yanru, Chen, Danghui, Qiu, Shuang
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines baicalein derivatives Carboxylic acids Chemical tests Esterification esterification reaction Kinases Mannich reaction NMR Nuclear magnetic resonance strontium chloride identification reaction
Online-Zugang:	Volltext
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