Suppression of bisphenol A‐induced oxidative stress by taurine promotes neuroprotection and restores altered neurobehavioral response in zebrafish (Danio rerio)
Bisphenol A (BPA) has been documented as a mediator for a number of health effects, including inflammation, oxidative stress, carcinogenicity, and mood dysfunction. The literature on the role of BPA in inducing altered neurobehavioral response and brain morphology and plausible neuroprotective role...
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| Veröffentlicht in: | Environmental toxicology 2021-11, Vol.36 (11), p.2342-2353 |
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| creator | Pradhan, Lilesh Kumar Sahoo, Pradyumna Kumar Aparna, Sai Sargam, Meghana Biswal, Amit Kumar Polai, Omkar Chauhan, Nishant Ranjan Das, Saroj Kumar |
| description | Bisphenol A (BPA) has been documented as a mediator for a number of health effects, including inflammation, oxidative stress, carcinogenicity, and mood dysfunction. The literature on the role of BPA in inducing altered neurobehavioral response and brain morphology and plausible neuroprotective role of taurine against BPA induced oxidative stress mediated neurotoxicity is limited. Therefore, the present experimental paradigm was set for 21 days to expound the neuroprotective efficacy of taurine against BPA‐induced neurotoxicity in zebrafish (Danio rerio) following waterborne exposure. Neurobehavioral studies were conducted by light–dark preference test (LDPT) and novel tank diving test (NTDT). To validate that the neuroprotective efficacy of taurine against BPA‐induced neurotoxicity is associated with the modulation of the antioxidant defense system, we have conducted biochemical studies in zebrafish brain. Changes in brain morphology leading to neurobehavioral variations following co‐supplementation of BPA and taurine were evaluated by Hoechst staining and cresyl violet staining (CVS) in periventricular gray zone (PGZ) of zebrafish brain. Our findings show that taurine co‐supplementation significantly improved the BPA‐induced altered scototaxis and explorative behavior of zebrafish. Further, BPA‐induced augmented oxidative stress was considerably ameliorated by taurine co‐supplementation. Subsequently, our observation also points toward the neuroprotective role of taurine against BPA‐induced neuronal pyknosis and chromatin condensation in PGZ of zebrafish brain. In a nutshell, the findings of the current study show the neuroprotective efficacy of taurine against BPA‐induced oxidative stress‐mediated neurotoxicity. Elucidation of the underlying signaling mechanism of taurine‐mediated neuroprotection would provide novel strategies for the prevention/treatment of BPA‐persuaded serious neurological consequences. |
| doi_str_mv | 10.1002/tox.23348 |
| format | Article |
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The literature on the role of BPA in inducing altered neurobehavioral response and brain morphology and plausible neuroprotective role of taurine against BPA induced oxidative stress mediated neurotoxicity is limited. Therefore, the present experimental paradigm was set for 21 days to expound the neuroprotective efficacy of taurine against BPA‐induced neurotoxicity in zebrafish (Danio rerio) following waterborne exposure. Neurobehavioral studies were conducted by light–dark preference test (LDPT) and novel tank diving test (NTDT). To validate that the neuroprotective efficacy of taurine against BPA‐induced neurotoxicity is associated with the modulation of the antioxidant defense system, we have conducted biochemical studies in zebrafish brain. Changes in brain morphology leading to neurobehavioral variations following co‐supplementation of BPA and taurine were evaluated by Hoechst staining and cresyl violet staining (CVS) in periventricular gray zone (PGZ) of zebrafish brain. Our findings show that taurine co‐supplementation significantly improved the BPA‐induced altered scototaxis and explorative behavior of zebrafish. Further, BPA‐induced augmented oxidative stress was considerably ameliorated by taurine co‐supplementation. Subsequently, our observation also points toward the neuroprotective role of taurine against BPA‐induced neuronal pyknosis and chromatin condensation in PGZ of zebrafish brain. In a nutshell, the findings of the current study show the neuroprotective efficacy of taurine against BPA‐induced oxidative stress‐mediated neurotoxicity. Elucidation of the underlying signaling mechanism of taurine‐mediated neuroprotection would provide novel strategies for the prevention/treatment of BPA‐persuaded serious neurological consequences.</description><identifier>ISSN: 1520-4081</identifier><identifier>EISSN: 1522-7278</identifier><identifier>DOI: 10.1002/tox.23348</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Antioxidants ; Bisphenol A ; Brain ; Carcinogenicity ; Carcinogens ; Chromatin ; Danio rerio ; Exploratory behavior ; Freshwater fishes ; Morphology ; Neuroprotection ; Neurotoxicity ; Oxidative stress ; Scototaxis ; Staining ; Supplements ; Taurine ; Zebrafish</subject><ispartof>Environmental toxicology, 2021-11, Vol.36 (11), p.2342-2353</ispartof><rights>2021 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3308-462abe2443c5a8896761f93004f65e1378739005ab752ff90c366fb41715d91c3</citedby><cites>FETCH-LOGICAL-c3308-462abe2443c5a8896761f93004f65e1378739005ab752ff90c366fb41715d91c3</cites><orcidid>0000-0003-1505-2893 ; 0000-0002-6627-2469 ; 0000-0002-9137-6024 ; 0000-0002-5717-5333</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Ftox.23348$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Ftox.23348$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Pradhan, Lilesh Kumar</creatorcontrib><creatorcontrib>Sahoo, Pradyumna Kumar</creatorcontrib><creatorcontrib>Aparna, Sai</creatorcontrib><creatorcontrib>Sargam, Meghana</creatorcontrib><creatorcontrib>Biswal, Amit Kumar</creatorcontrib><creatorcontrib>Polai, Omkar</creatorcontrib><creatorcontrib>Chauhan, Nishant Ranjan</creatorcontrib><creatorcontrib>Das, Saroj Kumar</creatorcontrib><title>Suppression of bisphenol A‐induced oxidative stress by taurine promotes neuroprotection and restores altered neurobehavioral response in zebrafish (Danio rerio)</title><title>Environmental toxicology</title><description>Bisphenol A (BPA) has been documented as a mediator for a number of health effects, including inflammation, oxidative stress, carcinogenicity, and mood dysfunction. The literature on the role of BPA in inducing altered neurobehavioral response and brain morphology and plausible neuroprotective role of taurine against BPA induced oxidative stress mediated neurotoxicity is limited. Therefore, the present experimental paradigm was set for 21 days to expound the neuroprotective efficacy of taurine against BPA‐induced neurotoxicity in zebrafish (Danio rerio) following waterborne exposure. Neurobehavioral studies were conducted by light–dark preference test (LDPT) and novel tank diving test (NTDT). To validate that the neuroprotective efficacy of taurine against BPA‐induced neurotoxicity is associated with the modulation of the antioxidant defense system, we have conducted biochemical studies in zebrafish brain. Changes in brain morphology leading to neurobehavioral variations following co‐supplementation of BPA and taurine were evaluated by Hoechst staining and cresyl violet staining (CVS) in periventricular gray zone (PGZ) of zebrafish brain. Our findings show that taurine co‐supplementation significantly improved the BPA‐induced altered scototaxis and explorative behavior of zebrafish. Further, BPA‐induced augmented oxidative stress was considerably ameliorated by taurine co‐supplementation. Subsequently, our observation also points toward the neuroprotective role of taurine against BPA‐induced neuronal pyknosis and chromatin condensation in PGZ of zebrafish brain. In a nutshell, the findings of the current study show the neuroprotective efficacy of taurine against BPA‐induced oxidative stress‐mediated neurotoxicity. Elucidation of the underlying signaling mechanism of taurine‐mediated neuroprotection would provide novel strategies for the prevention/treatment of BPA‐persuaded serious neurological consequences.</description><subject>Antioxidants</subject><subject>Bisphenol A</subject><subject>Brain</subject><subject>Carcinogenicity</subject><subject>Carcinogens</subject><subject>Chromatin</subject><subject>Danio rerio</subject><subject>Exploratory behavior</subject><subject>Freshwater fishes</subject><subject>Morphology</subject><subject>Neuroprotection</subject><subject>Neurotoxicity</subject><subject>Oxidative stress</subject><subject>Scototaxis</subject><subject>Staining</subject><subject>Supplements</subject><subject>Taurine</subject><subject>Zebrafish</subject><issn>1520-4081</issn><issn>1522-7278</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp10btOwzAUBuAIgQQUBt7AEgsd0vqSxMlYlatUiYEisUVOcqy6CnawndIy8Qg8A4_Gk-C2rCy-yJ__Y-tE0QXBI4IxHXuzHlHGkvwgOiEppTGnPD_crXGc4JwcR6fOLTHGRZZmJ9H3U991FpxTRiMjUaVctwBtWjT5-fxSuulraJBZq0Z4tQLk_BajaoO86K3SgDprXo0HhzT01oSdh9pv04RuUMDehAGJ1oMNSTtUwUKslLGi3YLOaAdIafQBlRVSuQW6uhZamXBolRmeRUdStA7O_-ZB9Hx7M5_ex7PHu4fpZBbXjOE8TjIqKqBJwupU5HmR8YzIgmGcyCwFwnjOWYFxKiqeUikLXLMsk1VCOEmbgtRsEF3uc8Mf3vrw8HJpeqtDyZKmPMecBBvUcK9qa5yzIMvOqldhNyXB5bYFZWhBuWtBsOO9fVctbP6H5fzxZX_jF6ZOjMI</recordid><startdate>202111</startdate><enddate>202111</enddate><creator>Pradhan, Lilesh Kumar</creator><creator>Sahoo, Pradyumna Kumar</creator><creator>Aparna, Sai</creator><creator>Sargam, Meghana</creator><creator>Biswal, Amit Kumar</creator><creator>Polai, Omkar</creator><creator>Chauhan, Nishant Ranjan</creator><creator>Das, Saroj Kumar</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QH</scope><scope>7ST</scope><scope>7TN</scope><scope>7U7</scope><scope>7UA</scope><scope>C1K</scope><scope>F1W</scope><scope>H97</scope><scope>K9.</scope><scope>L.G</scope><scope>M7N</scope><scope>SOI</scope><orcidid>https://orcid.org/0000-0003-1505-2893</orcidid><orcidid>https://orcid.org/0000-0002-6627-2469</orcidid><orcidid>https://orcid.org/0000-0002-9137-6024</orcidid><orcidid>https://orcid.org/0000-0002-5717-5333</orcidid></search><sort><creationdate>202111</creationdate><title>Suppression of bisphenol A‐induced oxidative stress by taurine promotes neuroprotection and restores altered neurobehavioral response in zebrafish (Danio rerio)</title><author>Pradhan, Lilesh Kumar ; Sahoo, Pradyumna Kumar ; Aparna, Sai ; Sargam, Meghana ; Biswal, Amit Kumar ; Polai, Omkar ; Chauhan, Nishant Ranjan ; Das, Saroj Kumar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3308-462abe2443c5a8896761f93004f65e1378739005ab752ff90c366fb41715d91c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antioxidants</topic><topic>Bisphenol A</topic><topic>Brain</topic><topic>Carcinogenicity</topic><topic>Carcinogens</topic><topic>Chromatin</topic><topic>Danio rerio</topic><topic>Exploratory behavior</topic><topic>Freshwater fishes</topic><topic>Morphology</topic><topic>Neuroprotection</topic><topic>Neurotoxicity</topic><topic>Oxidative stress</topic><topic>Scototaxis</topic><topic>Staining</topic><topic>Supplements</topic><topic>Taurine</topic><topic>Zebrafish</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pradhan, Lilesh Kumar</creatorcontrib><creatorcontrib>Sahoo, Pradyumna Kumar</creatorcontrib><creatorcontrib>Aparna, Sai</creatorcontrib><creatorcontrib>Sargam, Meghana</creatorcontrib><creatorcontrib>Biswal, Amit Kumar</creatorcontrib><creatorcontrib>Polai, Omkar</creatorcontrib><creatorcontrib>Chauhan, Nishant Ranjan</creatorcontrib><creatorcontrib>Das, Saroj Kumar</creatorcontrib><collection>CrossRef</collection><collection>Aqualine</collection><collection>Environment Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Environment Abstracts</collection><jtitle>Environmental toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pradhan, Lilesh Kumar</au><au>Sahoo, Pradyumna Kumar</au><au>Aparna, Sai</au><au>Sargam, Meghana</au><au>Biswal, Amit Kumar</au><au>Polai, Omkar</au><au>Chauhan, Nishant Ranjan</au><au>Das, Saroj Kumar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Suppression of bisphenol A‐induced oxidative stress by taurine promotes neuroprotection and restores altered neurobehavioral response in zebrafish (Danio rerio)</atitle><jtitle>Environmental toxicology</jtitle><date>2021-11</date><risdate>2021</risdate><volume>36</volume><issue>11</issue><spage>2342</spage><epage>2353</epage><pages>2342-2353</pages><issn>1520-4081</issn><eissn>1522-7278</eissn><abstract>Bisphenol A (BPA) has been documented as a mediator for a number of health effects, including inflammation, oxidative stress, carcinogenicity, and mood dysfunction. The literature on the role of BPA in inducing altered neurobehavioral response and brain morphology and plausible neuroprotective role of taurine against BPA induced oxidative stress mediated neurotoxicity is limited. Therefore, the present experimental paradigm was set for 21 days to expound the neuroprotective efficacy of taurine against BPA‐induced neurotoxicity in zebrafish (Danio rerio) following waterborne exposure. Neurobehavioral studies were conducted by light–dark preference test (LDPT) and novel tank diving test (NTDT). To validate that the neuroprotective efficacy of taurine against BPA‐induced neurotoxicity is associated with the modulation of the antioxidant defense system, we have conducted biochemical studies in zebrafish brain. Changes in brain morphology leading to neurobehavioral variations following co‐supplementation of BPA and taurine were evaluated by Hoechst staining and cresyl violet staining (CVS) in periventricular gray zone (PGZ) of zebrafish brain. Our findings show that taurine co‐supplementation significantly improved the BPA‐induced altered scototaxis and explorative behavior of zebrafish. Further, BPA‐induced augmented oxidative stress was considerably ameliorated by taurine co‐supplementation. Subsequently, our observation also points toward the neuroprotective role of taurine against BPA‐induced neuronal pyknosis and chromatin condensation in PGZ of zebrafish brain. In a nutshell, the findings of the current study show the neuroprotective efficacy of taurine against BPA‐induced oxidative stress‐mediated neurotoxicity. Elucidation of the underlying signaling mechanism of taurine‐mediated neuroprotection would provide novel strategies for the prevention/treatment of BPA‐persuaded serious neurological consequences.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><doi>10.1002/tox.23348</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-1505-2893</orcidid><orcidid>https://orcid.org/0000-0002-6627-2469</orcidid><orcidid>https://orcid.org/0000-0002-9137-6024</orcidid><orcidid>https://orcid.org/0000-0002-5717-5333</orcidid></addata></record> |
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| subjects | Antioxidants Bisphenol A Brain Carcinogenicity Carcinogens Chromatin Danio rerio Exploratory behavior Freshwater fishes Morphology Neuroprotection Neurotoxicity Oxidative stress Scototaxis Staining Supplements Taurine Zebrafish |
| title | Suppression of bisphenol A‐induced oxidative stress by taurine promotes neuroprotection and restores altered neurobehavioral response in zebrafish (Danio rerio) |
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