Protective effects of Cinnamomum verum, Cinnamomum cassia and cinnamaldehyde against 6-OHDA-induced apoptosis in PC12 cells
Cinnamon ( Cinnamomum verum and C. cassia ) is a medicinal plant, widely-used as a culinary spice. It possesses various therapeutic effects and can slow down the progression of neurological disorders impressively. In this article, the effects of hydro-alcohol extract and essential oil of C. verum an...
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| Veröffentlicht in: | Molecular biology reports 2020-04, Vol.47 (4), p.2437-2445 |
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| creator | Ramazani, Elham YazdFazeli, Mahdi Emami, Seyed Ahmad Mohtashami, Leila Javadi, Behjat Asili, Javad Tayarani-Najaran, Zahra |
| description | Cinnamon (
Cinnamomum verum
and
C. cassia
) is a medicinal plant, widely-used as a culinary spice. It possesses various therapeutic effects and can slow down the progression of neurological disorders impressively. In this article, the effects of hydro-alcohol extract and essential oil of
C. verum
and
C. cassia
and its main bioactive component cinnamaldehyde, has been examined on 6-OHDA-exposed PC12 cells as an in vitro model of Parkinson's disease. The cytotoxicity and cell apoptosis has been induced by 6-OHDA in PC12 cells. The protective effect was determined by measuring cell viability, the amount of reactive oxygen species (ROS), and apoptosis. Cell viability and apoptosis were assessed using resazurin assay, flow cytometry of propidium iodide (PI) stained cells, and western blot analysis. 6-OHDA resulted in the death and apoptosis of cells while, pretreatment with the extract and essential oil of
C. verum
and
C. cassia
at 20 µg/ml and cinnamaldehyde at 5 and 10 µM for 24 h could significantly increase the viability (p |
| doi_str_mv | 10.1007/s11033-020-05284-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2577745739</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2577745739</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-16b952d6c9bb030d7179bd642b3db8bf02a6ee97b59a926e67519b3d62b80dd3</originalsourceid><addsrcrecordid>eNp9kElLBDEQhYMozrj8AQ8S8Go0SyfpHGVcQZg5eA9JJ6099GbSLTT-eaMzLidPVVS9eo_6ADgh-IJgLC8jIZgxhClGmNM8Q9MOmBMuGcqUzHfBHDNMUJZzMgMHMa4xxhmRfB_MGCVCcM7m4H0VusEXQ_XmoS_L1EXYlXBRta1pumZs4JsPY3P-d1KYGCsDTetg8TU1tfMvk_PQPJuqjQMUaHl_fYWq1o2Fd9D0XT90sYqwauFqQSgsfF3HI7BXmjr64209BE-3N0-Le_S4vHtYXD2igkk-ICKs4tSJQlmbPnKSSGWdyKhlzua2xNQI75W0XBlFhReSE5V2gtocO8cOwdnGtg_d6-jjoNfdGNqUqCmXUmaJmEoqulEVoYsx-FL3oWpMmDTB-hO33uDWCbf-wq2ndHS6tR5t493PyTffJGAbQUyr9tmH3-x_bD8AYWyL0g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2577745739</pqid></control><display><type>article</type><title>Protective effects of Cinnamomum verum, Cinnamomum cassia and cinnamaldehyde against 6-OHDA-induced apoptosis in PC12 cells</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Ramazani, Elham ; YazdFazeli, Mahdi ; Emami, Seyed Ahmad ; Mohtashami, Leila ; Javadi, Behjat ; Asili, Javad ; Tayarani-Najaran, Zahra</creator><creatorcontrib>Ramazani, Elham ; YazdFazeli, Mahdi ; Emami, Seyed Ahmad ; Mohtashami, Leila ; Javadi, Behjat ; Asili, Javad ; Tayarani-Najaran, Zahra</creatorcontrib><description>Cinnamon (
Cinnamomum verum
and
C. cassia
) is a medicinal plant, widely-used as a culinary spice. It possesses various therapeutic effects and can slow down the progression of neurological disorders impressively. In this article, the effects of hydro-alcohol extract and essential oil of
C. verum
and
C. cassia
and its main bioactive component cinnamaldehyde, has been examined on 6-OHDA-exposed PC12 cells as an in vitro model of Parkinson's disease. The cytotoxicity and cell apoptosis has been induced by 6-OHDA in PC12 cells. The protective effect was determined by measuring cell viability, the amount of reactive oxygen species (ROS), and apoptosis. Cell viability and apoptosis were assessed using resazurin assay, flow cytometry of propidium iodide (PI) stained cells, and western blot analysis. 6-OHDA resulted in the death and apoptosis of cells while, pretreatment with the extract and essential oil of
C. verum
and
C. cassia
at 20 µg/ml and cinnamaldehyde at 5 and 10 µM for 24 h could significantly increase the viability (p < 0.001), and decrease ROS content (p < 0.05). Pretreatment with the extracts increased survivin and decreased cyt-
c
whereas, pretreatment with the essential oil decreased cyt-
c
, increased survivin, and reduced P-p44/42/p44/42 levels to a level near that of the related control. The extract and essential oil of
C. verum
and
C. cassia
can be effective against 6-OHDA cytotoxicity. It is suggested that, the synergistic effects of cinnamaldehyde and other components of extract and essential oil promote cinnamon’s medicinal properties.</description><identifier>ISSN: 0301-4851</identifier><identifier>EISSN: 1573-4978</identifier><identifier>DOI: 10.1007/s11033-020-05284-y</identifier><identifier>PMID: 32166553</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Acrolein - analogs & derivatives ; Acrolein - metabolism ; Acrolein - pharmacology ; Animal Anatomy ; Animal Biochemistry ; Animals ; Apoptosis ; Apoptosis - drug effects ; Biomedical and Life Sciences ; Cell death ; Cell Death - drug effects ; Cell Survival - drug effects ; Cell viability ; Cinnamaldehyde ; Cinnamomum aromaticum - metabolism ; Cinnamomum verum ; Cinnamomum zeylanicum - metabolism ; Cinnamon ; Cytotoxicity ; Essential oils ; Flow cytometry ; Histology ; Life Sciences ; Medicinal plants ; Morphology ; Movement disorders ; Neurodegenerative diseases ; Neurological diseases ; Oils & fats ; Oils, Volatile - pharmacology ; Original Article ; Oxidopamine ; Parkinson's disease ; PC12 Cells ; Pheochromocytoma cells ; Plant Extracts - pharmacology ; Propidium iodide ; Rats ; Reactive oxygen species ; Survivin</subject><ispartof>Molecular biology reports, 2020-04, Vol.47 (4), p.2437-2445</ispartof><rights>Springer Nature B.V. 2020</rights><rights>Springer Nature B.V. 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-16b952d6c9bb030d7179bd642b3db8bf02a6ee97b59a926e67519b3d62b80dd3</citedby><cites>FETCH-LOGICAL-c375t-16b952d6c9bb030d7179bd642b3db8bf02a6ee97b59a926e67519b3d62b80dd3</cites><orcidid>0000-0001-8899-0886</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11033-020-05284-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11033-020-05284-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32166553$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ramazani, Elham</creatorcontrib><creatorcontrib>YazdFazeli, Mahdi</creatorcontrib><creatorcontrib>Emami, Seyed Ahmad</creatorcontrib><creatorcontrib>Mohtashami, Leila</creatorcontrib><creatorcontrib>Javadi, Behjat</creatorcontrib><creatorcontrib>Asili, Javad</creatorcontrib><creatorcontrib>Tayarani-Najaran, Zahra</creatorcontrib><title>Protective effects of Cinnamomum verum, Cinnamomum cassia and cinnamaldehyde against 6-OHDA-induced apoptosis in PC12 cells</title><title>Molecular biology reports</title><addtitle>Mol Biol Rep</addtitle><addtitle>Mol Biol Rep</addtitle><description>Cinnamon (
Cinnamomum verum
and
C. cassia
) is a medicinal plant, widely-used as a culinary spice. It possesses various therapeutic effects and can slow down the progression of neurological disorders impressively. In this article, the effects of hydro-alcohol extract and essential oil of
C. verum
and
C. cassia
and its main bioactive component cinnamaldehyde, has been examined on 6-OHDA-exposed PC12 cells as an in vitro model of Parkinson's disease. The cytotoxicity and cell apoptosis has been induced by 6-OHDA in PC12 cells. The protective effect was determined by measuring cell viability, the amount of reactive oxygen species (ROS), and apoptosis. Cell viability and apoptosis were assessed using resazurin assay, flow cytometry of propidium iodide (PI) stained cells, and western blot analysis. 6-OHDA resulted in the death and apoptosis of cells while, pretreatment with the extract and essential oil of
C. verum
and
C. cassia
at 20 µg/ml and cinnamaldehyde at 5 and 10 µM for 24 h could significantly increase the viability (p < 0.001), and decrease ROS content (p < 0.05). Pretreatment with the extracts increased survivin and decreased cyt-
c
whereas, pretreatment with the essential oil decreased cyt-
c
, increased survivin, and reduced P-p44/42/p44/42 levels to a level near that of the related control. The extract and essential oil of
C. verum
and
C. cassia
can be effective against 6-OHDA cytotoxicity. It is suggested that, the synergistic effects of cinnamaldehyde and other components of extract and essential oil promote cinnamon’s medicinal properties.</description><subject>Acrolein - analogs & derivatives</subject><subject>Acrolein - metabolism</subject><subject>Acrolein - pharmacology</subject><subject>Animal Anatomy</subject><subject>Animal Biochemistry</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Biomedical and Life Sciences</subject><subject>Cell death</subject><subject>Cell Death - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Cell viability</subject><subject>Cinnamaldehyde</subject><subject>Cinnamomum aromaticum - metabolism</subject><subject>Cinnamomum verum</subject><subject>Cinnamomum zeylanicum - metabolism</subject><subject>Cinnamon</subject><subject>Cytotoxicity</subject><subject>Essential oils</subject><subject>Flow cytometry</subject><subject>Histology</subject><subject>Life Sciences</subject><subject>Medicinal plants</subject><subject>Morphology</subject><subject>Movement disorders</subject><subject>Neurodegenerative diseases</subject><subject>Neurological diseases</subject><subject>Oils & fats</subject><subject>Oils, Volatile - pharmacology</subject><subject>Original Article</subject><subject>Oxidopamine</subject><subject>Parkinson's disease</subject><subject>PC12 Cells</subject><subject>Pheochromocytoma cells</subject><subject>Plant Extracts - pharmacology</subject><subject>Propidium iodide</subject><subject>Rats</subject><subject>Reactive oxygen species</subject><subject>Survivin</subject><issn>0301-4851</issn><issn>1573-4978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kElLBDEQhYMozrj8AQ8S8Go0SyfpHGVcQZg5eA9JJ6099GbSLTT-eaMzLidPVVS9eo_6ADgh-IJgLC8jIZgxhClGmNM8Q9MOmBMuGcqUzHfBHDNMUJZzMgMHMa4xxhmRfB_MGCVCcM7m4H0VusEXQ_XmoS_L1EXYlXBRta1pumZs4JsPY3P-d1KYGCsDTetg8TU1tfMvk_PQPJuqjQMUaHl_fYWq1o2Fd9D0XT90sYqwauFqQSgsfF3HI7BXmjr64209BE-3N0-Le_S4vHtYXD2igkk-ICKs4tSJQlmbPnKSSGWdyKhlzua2xNQI75W0XBlFhReSE5V2gtocO8cOwdnGtg_d6-jjoNfdGNqUqCmXUmaJmEoqulEVoYsx-FL3oWpMmDTB-hO33uDWCbf-wq2ndHS6tR5t493PyTffJGAbQUyr9tmH3-x_bD8AYWyL0g</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Ramazani, Elham</creator><creator>YazdFazeli, Mahdi</creator><creator>Emami, Seyed Ahmad</creator><creator>Mohtashami, Leila</creator><creator>Javadi, Behjat</creator><creator>Asili, Javad</creator><creator>Tayarani-Najaran, Zahra</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><orcidid>https://orcid.org/0000-0001-8899-0886</orcidid></search><sort><creationdate>20200401</creationdate><title>Protective effects of Cinnamomum verum, Cinnamomum cassia and cinnamaldehyde against 6-OHDA-induced apoptosis in PC12 cells</title><author>Ramazani, Elham ; YazdFazeli, Mahdi ; Emami, Seyed Ahmad ; Mohtashami, Leila ; Javadi, Behjat ; Asili, Javad ; Tayarani-Najaran, Zahra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-16b952d6c9bb030d7179bd642b3db8bf02a6ee97b59a926e67519b3d62b80dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acrolein - analogs & derivatives</topic><topic>Acrolein - metabolism</topic><topic>Acrolein - pharmacology</topic><topic>Animal Anatomy</topic><topic>Animal Biochemistry</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Biomedical and Life Sciences</topic><topic>Cell death</topic><topic>Cell Death - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Cell viability</topic><topic>Cinnamaldehyde</topic><topic>Cinnamomum aromaticum - metabolism</topic><topic>Cinnamomum verum</topic><topic>Cinnamomum zeylanicum - metabolism</topic><topic>Cinnamon</topic><topic>Cytotoxicity</topic><topic>Essential oils</topic><topic>Flow cytometry</topic><topic>Histology</topic><topic>Life Sciences</topic><topic>Medicinal plants</topic><topic>Morphology</topic><topic>Movement disorders</topic><topic>Neurodegenerative diseases</topic><topic>Neurological diseases</topic><topic>Oils & fats</topic><topic>Oils, Volatile - pharmacology</topic><topic>Original Article</topic><topic>Oxidopamine</topic><topic>Parkinson's disease</topic><topic>PC12 Cells</topic><topic>Pheochromocytoma cells</topic><topic>Plant Extracts - pharmacology</topic><topic>Propidium iodide</topic><topic>Rats</topic><topic>Reactive oxygen species</topic><topic>Survivin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramazani, Elham</creatorcontrib><creatorcontrib>YazdFazeli, Mahdi</creatorcontrib><creatorcontrib>Emami, Seyed Ahmad</creatorcontrib><creatorcontrib>Mohtashami, Leila</creatorcontrib><creatorcontrib>Javadi, Behjat</creatorcontrib><creatorcontrib>Asili, Javad</creatorcontrib><creatorcontrib>Tayarani-Najaran, Zahra</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><jtitle>Molecular biology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramazani, Elham</au><au>YazdFazeli, Mahdi</au><au>Emami, Seyed Ahmad</au><au>Mohtashami, Leila</au><au>Javadi, Behjat</au><au>Asili, Javad</au><au>Tayarani-Najaran, Zahra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effects of Cinnamomum verum, Cinnamomum cassia and cinnamaldehyde against 6-OHDA-induced apoptosis in PC12 cells</atitle><jtitle>Molecular biology reports</jtitle><stitle>Mol Biol Rep</stitle><addtitle>Mol Biol Rep</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>47</volume><issue>4</issue><spage>2437</spage><epage>2445</epage><pages>2437-2445</pages><issn>0301-4851</issn><eissn>1573-4978</eissn><abstract>Cinnamon (
Cinnamomum verum
and
C. cassia
) is a medicinal plant, widely-used as a culinary spice. It possesses various therapeutic effects and can slow down the progression of neurological disorders impressively. In this article, the effects of hydro-alcohol extract and essential oil of
C. verum
and
C. cassia
and its main bioactive component cinnamaldehyde, has been examined on 6-OHDA-exposed PC12 cells as an in vitro model of Parkinson's disease. The cytotoxicity and cell apoptosis has been induced by 6-OHDA in PC12 cells. The protective effect was determined by measuring cell viability, the amount of reactive oxygen species (ROS), and apoptosis. Cell viability and apoptosis were assessed using resazurin assay, flow cytometry of propidium iodide (PI) stained cells, and western blot analysis. 6-OHDA resulted in the death and apoptosis of cells while, pretreatment with the extract and essential oil of
C. verum
and
C. cassia
at 20 µg/ml and cinnamaldehyde at 5 and 10 µM for 24 h could significantly increase the viability (p < 0.001), and decrease ROS content (p < 0.05). Pretreatment with the extracts increased survivin and decreased cyt-
c
whereas, pretreatment with the essential oil decreased cyt-
c
, increased survivin, and reduced P-p44/42/p44/42 levels to a level near that of the related control. The extract and essential oil of
C. verum
and
C. cassia
can be effective against 6-OHDA cytotoxicity. It is suggested that, the synergistic effects of cinnamaldehyde and other components of extract and essential oil promote cinnamon’s medicinal properties.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>32166553</pmid><doi>10.1007/s11033-020-05284-y</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8899-0886</orcidid></addata></record> |
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| ispartof | Molecular biology reports, 2020-04, Vol.47 (4), p.2437-2445 |
| issn | 0301-4851 1573-4978 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Acrolein - analogs & derivatives Acrolein - metabolism Acrolein - pharmacology Animal Anatomy Animal Biochemistry Animals Apoptosis Apoptosis - drug effects Biomedical and Life Sciences Cell death Cell Death - drug effects Cell Survival - drug effects Cell viability Cinnamaldehyde Cinnamomum aromaticum - metabolism Cinnamomum verum Cinnamomum zeylanicum - metabolism Cinnamon Cytotoxicity Essential oils Flow cytometry Histology Life Sciences Medicinal plants Morphology Movement disorders Neurodegenerative diseases Neurological diseases Oils & fats Oils, Volatile - pharmacology Original Article Oxidopamine Parkinson's disease PC12 Cells Pheochromocytoma cells Plant Extracts - pharmacology Propidium iodide Rats Reactive oxygen species Survivin |
| title | Protective effects of Cinnamomum verum, Cinnamomum cassia and cinnamaldehyde against 6-OHDA-induced apoptosis in PC12 cells |
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