Poloxamer 188 vs Placebo for Painful Vaso-occlusive Episodes in Children and Adults With Sickle Cell Disease/Poloxamer 188 vs Placebo for Painful Vaso-occlusive Episodes in Children and Adults With Sickle Cell Disease/Poloxamer 188 vs Placebo for Painful Vaso-occlusive Episodes in Children and Adults With Sickle Cell Disease-Reply

The EPIC study investigators were aware of the prior cardiac studies cited by Drs Kenter and Cohen suggesting nephrotoxicity due to poloxamer 188. It is important to note that these early studies used commercial-grade poloxamer 188. Subsequent studies showed that removal of impurities from this prep...

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Veröffentlicht in:	JAMA : the journal of the American Medical Association 2021-09, Vol.326 (10), p.974
Hauptverfasser:	Kenter, Marcel J H, Cohen, Adam F, Gurkan, Umut A, Casella, James F, Kronsberg, Shari S, Gorney, Rebecca T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Albumins Children Clearances Creatinine Immunoglobulin G Impurities Kidneys N-Acetylglucosaminidase Permeability Placebos Poloxamers Retinol-binding protein Sickle cell disease Vitamin A
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