Surfaceome Profiling of Rhabdomyosarcoma Reveals B7-H3 as a Mediator of Immune Evasion

Novel therapeutic strategies are needed for the treatment of rhabdomyosarcoma (RMS), the most common soft-tissue sarcoma in children. By using a combination of cell surface proteomics and transcriptomic profiling of RMS and normal muscle, we generated a catalog of targetable cell surface proteins en...

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Veröffentlicht in:	Cancers 2021-09, Vol.13 (18), p.4528
Hauptverfasser:	Lavoie, Roxane R., Gargollo, Patricio C., Ahmed, Mohamed E., Kim, Yohan, Baer, Emily, Phelps, Doris A., Charlesworth, Cristine M., Madden, Benjamin J., Wang, Liguo, Houghton, Peter J., Cheville, John, Dong, Haidong, Granberg, Candace F., Lucien, Fabrice
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antigen (tumor-associated) CD8 antigen Cell density Cell surface Chemotherapy Children Cytotoxicity Genes Immune checkpoint Immune evasion Immunoregulation Immunotherapy Lymphocytes T Macrophages Mass spectrometry Proteins Proteomics Rhabdomyosarcoma Scientific imaging Transcriptomics Tumor cells Tumors
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