Hyperbranched polyethylenimine–based polymeric nanoparticles: synthesis, properties, and an application in selective response to copper ion
Hyperbranched polyethylenimines (hPEIs) have diverse biological applications; however, the intrinsic toxicity is a major concern in developing hPEI-based biomaterials. This work reports the synthesis, properties, and an application as a biocompatible hPEI-based material, namely, fluorescent oxidized...
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| Veröffentlicht in: | Colloid and polymer science 2021-10, Vol.299 (10), p.1577-1586 |
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| creator | Zhong, Jun Wang, Bingbing Sun, Kai Duan, Jiang |
| description | Hyperbranched polyethylenimines (hPEIs) have diverse biological applications; however, the intrinsic toxicity is a major concern in developing hPEI-based biomaterials. This work reports the synthesis, properties, and an application as a biocompatible hPEI-based material, namely, fluorescent oxidized hPEI polymeric nanoparticles (F-ohPEIs). The synthesis was achieved through oxidation of hPEI with H
2
O
2
and subsequent cross-linking with formaldehyde, imparting to F-ohPEIs’ desired properties such as remarkably reduced positive charge density, hydrolytic degradability, low cytotoxicity, strong fluorescence emission, and stability. Furthermore, as an application, F-ohPEI demonstrated the ability to selectively respond to cupric ion in a wide concentration range of 0.02 ~ 10 μM with a low limit of detection of 0.013 μM. The synthesis strategy along with the F-ohPEI nanoparticles developed in this work is expected to find promising application in fabricating biocompatible hPEI-based biomaterials.
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| doi_str_mv | 10.1007/s00396-021-04885-8 |
| format | Article |
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2
O
2
and subsequent cross-linking with formaldehyde, imparting to F-ohPEIs’ desired properties such as remarkably reduced positive charge density, hydrolytic degradability, low cytotoxicity, strong fluorescence emission, and stability. Furthermore, as an application, F-ohPEI demonstrated the ability to selectively respond to cupric ion in a wide concentration range of 0.02 ~ 10 μM with a low limit of detection of 0.013 μM. The synthesis strategy along with the F-ohPEI nanoparticles developed in this work is expected to find promising application in fabricating biocompatible hPEI-based biomaterials.
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2
O
2
and subsequent cross-linking with formaldehyde, imparting to F-ohPEIs’ desired properties such as remarkably reduced positive charge density, hydrolytic degradability, low cytotoxicity, strong fluorescence emission, and stability. Furthermore, as an application, F-ohPEI demonstrated the ability to selectively respond to cupric ion in a wide concentration range of 0.02 ~ 10 μM with a low limit of detection of 0.013 μM. The synthesis strategy along with the F-ohPEI nanoparticles developed in this work is expected to find promising application in fabricating biocompatible hPEI-based biomaterials.
Graphical abstract</description><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Characterization and Evaluation of Materials</subject><subject>Charge density</subject><subject>Chemical synthesis</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Complex Fluids and Microfluidics</subject><subject>Crosslinking</subject><subject>Cupric ions</subject><subject>Fluorescence</subject><subject>Food Science</subject><subject>Hydrogen peroxide</subject><subject>Nanoparticles</subject><subject>Nanotechnology and Microengineering</subject><subject>Original Contribution</subject><subject>Oxidation</subject><subject>Physical Chemistry</subject><subject>Polyethyleneimine</subject><subject>Polymer Sciences</subject><subject>Soft and Granular Matter</subject><subject>Toxicity</subject><issn>0303-402X</issn><issn>1435-1536</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9kM9KHTEUh4NU8Nb2BboKuHXsyZ_JzLgTsbVwoZsK3YVM7hlvZG4SkyjMzhfoyjfskxh7BXddhBM43--X8BHyhcEZA-i-ZgAxqAY4a0D2fdv0B2TFpGgb1gr1gaxAgGgk8N9H5GPOdwAgB6VW5M_1EjGNyXi7xQ2NYV6wbJcZvds5j3-fnkeT3xY7TM5Sb3yIJhVnZ8znNC--bDG7fEpjCrWrOKx34zf1UBPj7KwpLnjqPM04oy3uEWnCHIPPSEugNsSao5X5RA4nM2f8_DaPyc23q1-X18365_cflxfrxgo2lIZ1rEPONy0bTLtREwPTcrTKyJ5PnMGoxmpFql61Uo5iHDqBFZGAarDTJMQxOdn31i_fP2Au-i48JF-f1LztFIOug6FSfE_ZFHJOOOmY3M6kRTPQr9r1Xruu2vU_7bqvIbEP5Qr7W0zv1f9JvQBPFYmv</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Zhong, Jun</creator><creator>Wang, Bingbing</creator><creator>Sun, Kai</creator><creator>Duan, Jiang</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0001-8811-5344</orcidid></search><sort><creationdate>20211001</creationdate><title>Hyperbranched polyethylenimine–based polymeric nanoparticles: synthesis, properties, and an application in selective response to copper ion</title><author>Zhong, Jun ; Wang, Bingbing ; Sun, Kai ; Duan, Jiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-1717e22d519a5d6f10a52ec6a482f210b6b1004686544b3b973e0a540e69cff33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Characterization and Evaluation of Materials</topic><topic>Charge density</topic><topic>Chemical synthesis</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Complex Fluids and Microfluidics</topic><topic>Crosslinking</topic><topic>Cupric ions</topic><topic>Fluorescence</topic><topic>Food Science</topic><topic>Hydrogen peroxide</topic><topic>Nanoparticles</topic><topic>Nanotechnology and Microengineering</topic><topic>Original Contribution</topic><topic>Oxidation</topic><topic>Physical Chemistry</topic><topic>Polyethyleneimine</topic><topic>Polymer Sciences</topic><topic>Soft and Granular Matter</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhong, Jun</creatorcontrib><creatorcontrib>Wang, Bingbing</creatorcontrib><creatorcontrib>Sun, Kai</creatorcontrib><creatorcontrib>Duan, Jiang</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>Materials Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Colloid and polymer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhong, Jun</au><au>Wang, Bingbing</au><au>Sun, Kai</au><au>Duan, Jiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperbranched polyethylenimine–based polymeric nanoparticles: synthesis, properties, and an application in selective response to copper ion</atitle><jtitle>Colloid and polymer science</jtitle><stitle>Colloid Polym Sci</stitle><date>2021-10-01</date><risdate>2021</risdate><volume>299</volume><issue>10</issue><spage>1577</spage><epage>1586</epage><pages>1577-1586</pages><issn>0303-402X</issn><eissn>1435-1536</eissn><abstract>Hyperbranched polyethylenimines (hPEIs) have diverse biological applications; however, the intrinsic toxicity is a major concern in developing hPEI-based biomaterials. This work reports the synthesis, properties, and an application as a biocompatible hPEI-based material, namely, fluorescent oxidized hPEI polymeric nanoparticles (F-ohPEIs). The synthesis was achieved through oxidation of hPEI with H
2
O
2
and subsequent cross-linking with formaldehyde, imparting to F-ohPEIs’ desired properties such as remarkably reduced positive charge density, hydrolytic degradability, low cytotoxicity, strong fluorescence emission, and stability. Furthermore, as an application, F-ohPEI demonstrated the ability to selectively respond to cupric ion in a wide concentration range of 0.02 ~ 10 μM with a low limit of detection of 0.013 μM. The synthesis strategy along with the F-ohPEI nanoparticles developed in this work is expected to find promising application in fabricating biocompatible hPEI-based biomaterials.
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| subjects | Biocompatibility Biomedical materials Characterization and Evaluation of Materials Charge density Chemical synthesis Chemistry Chemistry and Materials Science Complex Fluids and Microfluidics Crosslinking Cupric ions Fluorescence Food Science Hydrogen peroxide Nanoparticles Nanotechnology and Microengineering Original Contribution Oxidation Physical Chemistry Polyethyleneimine Polymer Sciences Soft and Granular Matter Toxicity |
| title | Hyperbranched polyethylenimine–based polymeric nanoparticles: synthesis, properties, and an application in selective response to copper ion |
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