Tuberculosis contact investigation and short-course preventive therapy among young children in Africa
SETTING: The largest cities in Benin, Burkina Faso, Cameroon and Central African Republic.OBJECTIVE: To demonstrate the feasibility and document the effectiveness of household contact investigation and preventive therapy in resource-limited settings.DESIGN: Children under 5 years living at home with...
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| Veröffentlicht in: | The international journal of tuberculosis and lung disease 2020-04, Vol.24 (4), p.452-460 |
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| container_title | The international journal of tuberculosis and lung disease |
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| creator | Schwoebel, V. Koura, K. G. Adjobimey, M. Gnanou, S. Wandji, A. G. Gody, J-C. Delacourt, C. Detjen, A. Graham, S. M. Masserey, E. Mselatti, P. Roggi, A. Trébucq, A. |
| description | SETTING: The largest cities in Benin, Burkina Faso, Cameroon and Central African Republic.OBJECTIVE: To demonstrate the feasibility and document the effectiveness of household contact investigation and preventive therapy in resource-limited settings.DESIGN:
Children under 5 years living at home with adults with bacteriologically confirmed pulmonary tuberculosis (TB) were screened using questionnaire, clinical examination, tuberculin skin test and chest X-ray. Children free of active TB were offered preventive treatment with a 3-month rifampicin-isoniazid
(3RH) or 6-month isoniazid (6H) regimen in Benin. Children were followed-up monthly during treatment, then quarterly over 1 year. Costs of transportation, phone contacts and chest X-rays were covered.RESULTS: A total of 1965 children were enrolled, of whom 56 (2.8%) had prevalent
TB at inclusion. Among the 1909 children free of TB, 1745 (91%) started preventive therapy, 1642 (94%) of whom completed treatment. Mild adverse reactions, mostly gastrointestinal, were reported in 2% of children. One case of incident TB, possibly due to a late TB infection, was reported after
completing the 3RH regimen.CONCLUSION: Contact investigation and preventive therapy were successfully implemented in these resource-limited urban settings in programmatic conditions with few additional resources. The 3RH regimen is a valuable alternative to 6H for preventing TB. |
| doi_str_mv | 10.5588/ijtld.19.0712 |
| format | Article |
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Children under 5 years living at home with adults with bacteriologically confirmed pulmonary tuberculosis (TB) were screened using questionnaire, clinical examination, tuberculin skin test and chest X-ray. Children free of active TB were offered preventive treatment with a 3-month rifampicin-isoniazid
(3RH) or 6-month isoniazid (6H) regimen in Benin. Children were followed-up monthly during treatment, then quarterly over 1 year. Costs of transportation, phone contacts and chest X-rays were covered.RESULTS: A total of 1965 children were enrolled, of whom 56 (2.8%) had prevalent
TB at inclusion. Among the 1909 children free of TB, 1745 (91%) started preventive therapy, 1642 (94%) of whom completed treatment. Mild adverse reactions, mostly gastrointestinal, were reported in 2% of children. One case of incident TB, possibly due to a late TB infection, was reported after
completing the 3RH regimen.CONCLUSION: Contact investigation and preventive therapy were successfully implemented in these resource-limited urban settings in programmatic conditions with few additional resources. The 3RH regimen is a valuable alternative to 6H for preventing TB.</description><identifier>ISSN: 1027-3719</identifier><identifier>EISSN: 1815-7920</identifier><identifier>DOI: 10.5588/ijtld.19.0712</identifier><identifier>PMID: 32317071</identifier><language>eng</language><publisher>France: International Union Against Tuberculosis and Lung Disease</publisher><subject>Adult ; Benin - epidemiology ; Burkina Faso ; Cameroon - epidemiology ; Chest ; Child ; Child, Preschool ; Children ; Contact Tracing ; Humans ; Isoniazid ; Isoniazid - therapeutic use ; Latent Tb ; rifampicin ; Rifampin ; Skin tests ; Tb Prevalence ; Therapy ; Tuberculin ; Tuberculosis ; Tuberculosis - diagnosis ; Tuberculosis - drug therapy ; Tuberculosis - epidemiology ; Urban areas ; Urban environments</subject><ispartof>The international journal of tuberculosis and lung disease, 2020-04, Vol.24 (4), p.452-460</ispartof><rights>Copyright International Union against Tuberculosis and Lung Disease (IUATLD) Apr 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-8f52c6d0d74d3169e70278964bc94e04eaf9de56679d44a150a89e809390316f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32317071$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schwoebel, V.</creatorcontrib><creatorcontrib>Koura, K. G.</creatorcontrib><creatorcontrib>Adjobimey, M.</creatorcontrib><creatorcontrib>Gnanou, S.</creatorcontrib><creatorcontrib>Wandji, A. G.</creatorcontrib><creatorcontrib>Gody, J-C.</creatorcontrib><creatorcontrib>Delacourt, C.</creatorcontrib><creatorcontrib>Detjen, A.</creatorcontrib><creatorcontrib>Graham, S. M.</creatorcontrib><creatorcontrib>Masserey, E.</creatorcontrib><creatorcontrib>Mselatti, P.</creatorcontrib><creatorcontrib>Roggi, A.</creatorcontrib><creatorcontrib>Trébucq, A.</creatorcontrib><title>Tuberculosis contact investigation and short-course preventive therapy among young children in Africa</title><title>The international journal of tuberculosis and lung disease</title><addtitle>Int J Tuberc Lung Dis</addtitle><description>SETTING: The largest cities in Benin, Burkina Faso, Cameroon and Central African Republic.OBJECTIVE: To demonstrate the feasibility and document the effectiveness of household contact investigation and preventive therapy in resource-limited settings.DESIGN:
Children under 5 years living at home with adults with bacteriologically confirmed pulmonary tuberculosis (TB) were screened using questionnaire, clinical examination, tuberculin skin test and chest X-ray. Children free of active TB were offered preventive treatment with a 3-month rifampicin-isoniazid
(3RH) or 6-month isoniazid (6H) regimen in Benin. Children were followed-up monthly during treatment, then quarterly over 1 year. Costs of transportation, phone contacts and chest X-rays were covered.RESULTS: A total of 1965 children were enrolled, of whom 56 (2.8%) had prevalent
TB at inclusion. Among the 1909 children free of TB, 1745 (91%) started preventive therapy, 1642 (94%) of whom completed treatment. Mild adverse reactions, mostly gastrointestinal, were reported in 2% of children. One case of incident TB, possibly due to a late TB infection, was reported after
completing the 3RH regimen.CONCLUSION: Contact investigation and preventive therapy were successfully implemented in these resource-limited urban settings in programmatic conditions with few additional resources. The 3RH regimen is a valuable alternative to 6H for preventing TB.</description><subject>Adult</subject><subject>Benin - epidemiology</subject><subject>Burkina Faso</subject><subject>Cameroon - epidemiology</subject><subject>Chest</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Contact Tracing</subject><subject>Humans</subject><subject>Isoniazid</subject><subject>Isoniazid - therapeutic use</subject><subject>Latent Tb</subject><subject>rifampicin</subject><subject>Rifampin</subject><subject>Skin tests</subject><subject>Tb Prevalence</subject><subject>Therapy</subject><subject>Tuberculin</subject><subject>Tuberculosis</subject><subject>Tuberculosis - diagnosis</subject><subject>Tuberculosis - drug therapy</subject><subject>Tuberculosis - epidemiology</subject><subject>Urban areas</subject><subject>Urban environments</subject><issn>1027-3719</issn><issn>1815-7920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9rHCEUx6W0NGnSY69loJdeZqOOjnoM6Y8UAqGQnMXVN7sus7pVZ2H719fJbhoo1IPvHT5-9H1F6APBC86lvPKbMroFUQssCH2FzokkvBWK4te1x1S0nSDqDL3LeYMxJYSIt-isox0R9cA5godpCclOY8w-NzaGYmxpfNhDLn5lio-hMcE1eR1TaW2cUoZml2APofg9NGUNyewOjdnGsGoOcaq7XfvRJQhV01wPyVtzid4MZszw_lQv0OO3rw83t-3d_fcfN9d3rWW8L60cOLW9w04w15FegagDSNWzpVUMMAMzKAe874VyjBnCsZEKJFadwpUfugv0-ejdpfhrqiPorc8WxtEEiFPWtFMdV7KXtKKf_kE3dbhQX6cpF5wKzimpVHukbIo5Jxj0LvmtSQdNsJ7z10_5a6L0nH_lP56s03IL7i_9HHgFvhwBH1Y1QvNyq5_MbDr6KKZY46dF2anBTJtUaiWian7-T2OfTfPvz5-v95QFNisJlpTrGpvSDgYzjUUXk_Tqt87V-Qe7HbMG</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Schwoebel, V.</creator><creator>Koura, K. G.</creator><creator>Adjobimey, M.</creator><creator>Gnanou, S.</creator><creator>Wandji, A. G.</creator><creator>Gody, J-C.</creator><creator>Delacourt, C.</creator><creator>Detjen, A.</creator><creator>Graham, S. M.</creator><creator>Masserey, E.</creator><creator>Mselatti, P.</creator><creator>Roggi, A.</creator><creator>Trébucq, A.</creator><general>International Union Against Tuberculosis and Lung Disease</general><general>International Union against Tuberculosis and Lung Disease (IUATLD)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20200401</creationdate><title>Tuberculosis contact investigation and short-course preventive therapy among young children in Africa</title><author>Schwoebel, V. ; Koura, K. G. ; Adjobimey, M. ; Gnanou, S. ; Wandji, A. G. ; Gody, J-C. ; Delacourt, C. ; Detjen, A. ; Graham, S. 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G.</au><au>Adjobimey, M.</au><au>Gnanou, S.</au><au>Wandji, A. G.</au><au>Gody, J-C.</au><au>Delacourt, C.</au><au>Detjen, A.</au><au>Graham, S. M.</au><au>Masserey, E.</au><au>Mselatti, P.</au><au>Roggi, A.</au><au>Trébucq, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tuberculosis contact investigation and short-course preventive therapy among young children in Africa</atitle><jtitle>The international journal of tuberculosis and lung disease</jtitle><addtitle>Int J Tuberc Lung Dis</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>24</volume><issue>4</issue><spage>452</spage><epage>460</epage><pages>452-460</pages><issn>1027-3719</issn><eissn>1815-7920</eissn><abstract>SETTING: The largest cities in Benin, Burkina Faso, Cameroon and Central African Republic.OBJECTIVE: To demonstrate the feasibility and document the effectiveness of household contact investigation and preventive therapy in resource-limited settings.DESIGN:
Children under 5 years living at home with adults with bacteriologically confirmed pulmonary tuberculosis (TB) were screened using questionnaire, clinical examination, tuberculin skin test and chest X-ray. Children free of active TB were offered preventive treatment with a 3-month rifampicin-isoniazid
(3RH) or 6-month isoniazid (6H) regimen in Benin. Children were followed-up monthly during treatment, then quarterly over 1 year. Costs of transportation, phone contacts and chest X-rays were covered.RESULTS: A total of 1965 children were enrolled, of whom 56 (2.8%) had prevalent
TB at inclusion. Among the 1909 children free of TB, 1745 (91%) started preventive therapy, 1642 (94%) of whom completed treatment. Mild adverse reactions, mostly gastrointestinal, were reported in 2% of children. One case of incident TB, possibly due to a late TB infection, was reported after
completing the 3RH regimen.CONCLUSION: Contact investigation and preventive therapy were successfully implemented in these resource-limited urban settings in programmatic conditions with few additional resources. The 3RH regimen is a valuable alternative to 6H for preventing TB.</abstract><cop>France</cop><pub>International Union Against Tuberculosis and Lung Disease</pub><pmid>32317071</pmid><doi>10.5588/ijtld.19.0712</doi><tpages>9</tpages></addata></record> |
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| ispartof | The international journal of tuberculosis and lung disease, 2020-04, Vol.24 (4), p.452-460 |
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| subjects | Adult Benin - epidemiology Burkina Faso Cameroon - epidemiology Chest Child Child, Preschool Children Contact Tracing Humans Isoniazid Isoniazid - therapeutic use Latent Tb rifampicin Rifampin Skin tests Tb Prevalence Therapy Tuberculin Tuberculosis Tuberculosis - diagnosis Tuberculosis - drug therapy Tuberculosis - epidemiology Urban areas Urban environments |
| title | Tuberculosis contact investigation and short-course preventive therapy among young children in Africa |
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