A 27-year-old man with recurrent sinopulmonary and cutaneous infections
The increasing availability of genetic testing for modern immunologists in the evaluation of immune diseases could provide a definite diagnosis in elusive cases. A 27-year-old white male patient presented to the clinic with recurrent sinopulmonary and cutaneous infections since childhood. The patien...
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| Veröffentlicht in: | Allergy and asthma proceedings 2020-05, Vol.41 (3), p.218-223 |
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| creator | Wu, Shan Shan Sanan, Neha Schend, Jason Rowane, Marija Hostoffer, Robert W. |
| description | The increasing availability of genetic testing for modern immunologists in the evaluation of immune diseases could provide a definite diagnosis in elusive cases. A 27-year-old white male patient presented to the clinic with recurrent sinopulmonary and cutaneous infections since childhood.
The patient's mother had seronegative polyarthritis, and one of two sisters of the patient had chronic sinopulmonary infections. Serum immunoglobulins, immunoglobulin G (IgG) subclasses, lymphocyte subset markers, mannose-binding lectin, mitogen and antigen stimulation, bacteriophage
study, and Streptococcus pneumoniae titers to 23 serotypes were all normal. B-cell phenotyping revealed a decrease in both nonswitched memory B cells (CD19+CD27+IgD+) and switched memory B-cells (CD19+CD27+IgD−). Genetic
testing and the improvement of clinical symptoms after IgG replacement led to the final diagnosis. |
| doi_str_mv | 10.2500/aap.2020.41.190026 |
| format | Article |
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The patient's mother had seronegative polyarthritis, and one of two sisters of the patient had chronic sinopulmonary infections. Serum immunoglobulins, immunoglobulin G (IgG) subclasses, lymphocyte subset markers, mannose-binding lectin, mitogen and antigen stimulation, bacteriophage
study, and Streptococcus pneumoniae titers to 23 serotypes were all normal. B-cell phenotyping revealed a decrease in both nonswitched memory B cells (CD19+CD27+IgD+) and switched memory B-cells (CD19+CD27+IgD−). Genetic
testing and the improvement of clinical symptoms after IgG replacement led to the final diagnosis.</description><identifier>ISSN: 1088-5412</identifier><identifier>EISSN: 1539-6304</identifier><identifier>DOI: 10.2500/aap.2020.41.190026</identifier><identifier>PMID: 32375967</identifier><language>eng</language><publisher>United States: OceanSide Publications, Inc</publisher><subject>Ala181glu ; Antigens ; Asymptomatic ; B-Cell Dysfunction ; Baff ; Case reports ; CD19 antigen ; CD27 antigen ; Children ; Common Variable Immunodeficiency (cvid) ; Diagnosis ; Genetic screening ; Heterozygous Mutation ; IgG antibody ; Immunoglobulin D ; Immunoglobulin G ; Immunoglobulins ; Immunological diseases ; Immunological memory ; Infections ; Lymphocytes ; Lymphocytes B ; Mannose ; Mannose-binding lectin ; Medical diagnosis ; Memory cells ; Mens health ; Normal Immunoglobulins ; Patients ; Phages ; Phenotyping ; Polyarthritis ; Recurrent Infections ; Serotypes ; Signs and symptoms ; Skin diseases ; Streptococcus infections ; Taci ; TNFRSF13B</subject><ispartof>Allergy and asthma proceedings, 2020-05, Vol.41 (3), p.218-223</ispartof><rights>Copyright OceanSide Publications May 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32375967$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Shan Shan</creatorcontrib><creatorcontrib>Sanan, Neha</creatorcontrib><creatorcontrib>Schend, Jason</creatorcontrib><creatorcontrib>Rowane, Marija</creatorcontrib><creatorcontrib>Hostoffer, Robert W.</creatorcontrib><title>A 27-year-old man with recurrent sinopulmonary and cutaneous infections</title><title>Allergy and asthma proceedings</title><addtitle>Allergy Asthma Proc</addtitle><description>The increasing availability of genetic testing for modern immunologists in the evaluation of immune diseases could provide a definite diagnosis in elusive cases. A 27-year-old white male patient presented to the clinic with recurrent sinopulmonary and cutaneous infections since childhood.
The patient's mother had seronegative polyarthritis, and one of two sisters of the patient had chronic sinopulmonary infections. Serum immunoglobulins, immunoglobulin G (IgG) subclasses, lymphocyte subset markers, mannose-binding lectin, mitogen and antigen stimulation, bacteriophage
study, and Streptococcus pneumoniae titers to 23 serotypes were all normal. B-cell phenotyping revealed a decrease in both nonswitched memory B cells (CD19+CD27+IgD+) and switched memory B-cells (CD19+CD27+IgD−). Genetic
testing and the improvement of clinical symptoms after IgG replacement led to the final diagnosis.</description><subject>Ala181glu</subject><subject>Antigens</subject><subject>Asymptomatic</subject><subject>B-Cell Dysfunction</subject><subject>Baff</subject><subject>Case reports</subject><subject>CD19 antigen</subject><subject>CD27 antigen</subject><subject>Children</subject><subject>Common Variable Immunodeficiency (cvid)</subject><subject>Diagnosis</subject><subject>Genetic screening</subject><subject>Heterozygous Mutation</subject><subject>IgG antibody</subject><subject>Immunoglobulin D</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulins</subject><subject>Immunological diseases</subject><subject>Immunological memory</subject><subject>Infections</subject><subject>Lymphocytes</subject><subject>Lymphocytes B</subject><subject>Mannose</subject><subject>Mannose-binding lectin</subject><subject>Medical diagnosis</subject><subject>Memory cells</subject><subject>Mens health</subject><subject>Normal Immunoglobulins</subject><subject>Patients</subject><subject>Phages</subject><subject>Phenotyping</subject><subject>Polyarthritis</subject><subject>Recurrent Infections</subject><subject>Serotypes</subject><subject>Signs and symptoms</subject><subject>Skin diseases</subject><subject>Streptococcus infections</subject><subject>Taci</subject><subject>TNFRSF13B</subject><issn>1088-5412</issn><issn>1539-6304</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kc1u1TAQhS1ERUvhBVigSGy6ye34N8nyqoKCVAkWsLYcZ1xSJfbFdqjK0-M0Fyoh4c2MrDOfj88Q8obCjkmAS2MOOwYMdoLuaAfA1DNyRiXvasVBPC89tG0tBWWn5GVKdwBUcKVekFPOeCM71ZyR633FmvoBTazDNFSz8dX9mL9XEe0SI_pcpdGHwzLNwZv4UBk_VHbJxmNYUjV6hzaPwadX5MSZKeHrYz0n3z68_3r1sb75fP3pan9TW0F5roXpu54yVMq1zLEGsWtRcOrUAE6gGRy1q8tB8l6xoRWipQCqt5JbKWTPz8nFxj3E8GPBlPU8JovTtDnSjHddy6Vgqkjf_SO9C0v0xZ1mspGsZNg2RcU2lY0hpYhOH-I4l69qCnqNWZeY9RqzFlRvMZeht0f00s84_B35k2sR7DfB6G9LiObp6WDR-CcmPJ5C3hrg2sRcKuWF8eU_jNEeMeuC1_3qn4J6vhLLTaFSKRo9oDPLlHU2Ud_-0qkgfwMrFaaL</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>Wu, Shan Shan</creator><creator>Sanan, Neha</creator><creator>Schend, Jason</creator><creator>Rowane, Marija</creator><creator>Hostoffer, Robert W.</creator><general>OceanSide Publications, Inc</general><general>OceanSide Publications</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20200501</creationdate><title>A 27-year-old man with recurrent sinopulmonary and cutaneous infections</title><author>Wu, Shan Shan ; Sanan, Neha ; Schend, Jason ; Rowane, Marija ; Hostoffer, Robert W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-4ab9b12e66f82f27ee98e431f6d0f4eadf1c0143d53b62d84481006bc53c545b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Ala181glu</topic><topic>Antigens</topic><topic>Asymptomatic</topic><topic>B-Cell Dysfunction</topic><topic>Baff</topic><topic>Case reports</topic><topic>CD19 antigen</topic><topic>CD27 antigen</topic><topic>Children</topic><topic>Common Variable Immunodeficiency (cvid)</topic><topic>Diagnosis</topic><topic>Genetic screening</topic><topic>Heterozygous Mutation</topic><topic>IgG antibody</topic><topic>Immunoglobulin D</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulins</topic><topic>Immunological diseases</topic><topic>Immunological memory</topic><topic>Infections</topic><topic>Lymphocytes</topic><topic>Lymphocytes B</topic><topic>Mannose</topic><topic>Mannose-binding lectin</topic><topic>Medical diagnosis</topic><topic>Memory cells</topic><topic>Mens health</topic><topic>Normal Immunoglobulins</topic><topic>Patients</topic><topic>Phages</topic><topic>Phenotyping</topic><topic>Polyarthritis</topic><topic>Recurrent Infections</topic><topic>Serotypes</topic><topic>Signs and symptoms</topic><topic>Skin diseases</topic><topic>Streptococcus infections</topic><topic>Taci</topic><topic>TNFRSF13B</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Shan Shan</creatorcontrib><creatorcontrib>Sanan, Neha</creatorcontrib><creatorcontrib>Schend, Jason</creatorcontrib><creatorcontrib>Rowane, Marija</creatorcontrib><creatorcontrib>Hostoffer, Robert W.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Allergy and asthma proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Shan Shan</au><au>Sanan, Neha</au><au>Schend, Jason</au><au>Rowane, Marija</au><au>Hostoffer, Robert W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A 27-year-old man with recurrent sinopulmonary and cutaneous infections</atitle><jtitle>Allergy and asthma proceedings</jtitle><addtitle>Allergy Asthma Proc</addtitle><date>2020-05-01</date><risdate>2020</risdate><volume>41</volume><issue>3</issue><spage>218</spage><epage>223</epage><pages>218-223</pages><issn>1088-5412</issn><eissn>1539-6304</eissn><abstract>The increasing availability of genetic testing for modern immunologists in the evaluation of immune diseases could provide a definite diagnosis in elusive cases. A 27-year-old white male patient presented to the clinic with recurrent sinopulmonary and cutaneous infections since childhood.
The patient's mother had seronegative polyarthritis, and one of two sisters of the patient had chronic sinopulmonary infections. Serum immunoglobulins, immunoglobulin G (IgG) subclasses, lymphocyte subset markers, mannose-binding lectin, mitogen and antigen stimulation, bacteriophage
study, and Streptococcus pneumoniae titers to 23 serotypes were all normal. B-cell phenotyping revealed a decrease in both nonswitched memory B cells (CD19+CD27+IgD+) and switched memory B-cells (CD19+CD27+IgD−). Genetic
testing and the improvement of clinical symptoms after IgG replacement led to the final diagnosis.</abstract><cop>United States</cop><pub>OceanSide Publications, Inc</pub><pmid>32375967</pmid><doi>10.2500/aap.2020.41.190026</doi><tpages>6</tpages></addata></record> |
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| source | Alma/SFX Local Collection |
| subjects | Ala181glu Antigens Asymptomatic B-Cell Dysfunction Baff Case reports CD19 antigen CD27 antigen Children Common Variable Immunodeficiency (cvid) Diagnosis Genetic screening Heterozygous Mutation IgG antibody Immunoglobulin D Immunoglobulin G Immunoglobulins Immunological diseases Immunological memory Infections Lymphocytes Lymphocytes B Mannose Mannose-binding lectin Medical diagnosis Memory cells Mens health Normal Immunoglobulins Patients Phages Phenotyping Polyarthritis Recurrent Infections Serotypes Signs and symptoms Skin diseases Streptococcus infections Taci TNFRSF13B |
| title | A 27-year-old man with recurrent sinopulmonary and cutaneous infections |
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