Anti-asthmatic effects of tannic acid from Chinese natural gall nuts in a mouse model of allergic asthma
[Display omitted] •Tannic acid (TA) is a class of polyphenol that is present in higher plants.•AHR and airway inflammation in OVA-induced asthmatic mice were suppressed by TA.•TA also reduced mast cell numbers and mucus hypersecretion.•OVA-induced airway remodeling and NF-kB activation were attenuat...
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| Veröffentlicht in: | International immunopharmacology 2021-09, Vol.98, p.107847, Article 107847 |
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| creator | Rajasekar, Nandhine Sivanantham, Ayyanar Kar, Amrita Mukhopadhyay, Sramana Mahapatra, Santanu Kar Paramasivam, Sudhakar Gandhi Rajasekaran, Subbiah |
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•Tannic acid (TA) is a class of polyphenol that is present in higher plants.•AHR and airway inflammation in OVA-induced asthmatic mice were suppressed by TA.•TA also reduced mast cell numbers and mucus hypersecretion.•OVA-induced airway remodeling and NF-kB activation were attenuated by TA.•TA may be a potential therapeutic option for the treatment of allergic asthma.
Asthma is a chronic inflammatory disease of the airways, which is characterized by infiltration of inflammatory cells, airway hyperresponsiveness (AHR), and airway remodeling. This study aimed to explore the role and mechanism of tannic acid (TA), a naturally occurring plant-derived polyphenol, in murine asthma model. BALB/c mice were given ovalbumin (OVA) to establish an allergic asthma model. The results revealed that TA treatment significantly decreased OVA-induced AHR, inflammatory cells infiltration, and the expression of various inflammatory mediators (Th2 and Th1 cytokines, eotaxin, and total IgE). Additionally, TA treatment also attenuated increases in mucins (Muc5ac and Muc5b) expression, mucus production in airway goblet cells, mast cells infiltration, and airway remodeling induced by OVA exposure. Furthermore, OVA-induced NF-κB (nuclear factor- kappa B) activation and cell adhesion molecules expression in the lungs was suppressed by TA treatment. In conclusion, TA effectively attenuated AHR, inflammatory response, and airway remodeling in OVA-challenged asthmatic mice. Therefore, TA may be a potential therapeutic option against allergic asthma in clinical settings. |
| doi_str_mv | 10.1016/j.intimp.2021.107847 |
| format | Article |
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•Tannic acid (TA) is a class of polyphenol that is present in higher plants.•AHR and airway inflammation in OVA-induced asthmatic mice were suppressed by TA.•TA also reduced mast cell numbers and mucus hypersecretion.•OVA-induced airway remodeling and NF-kB activation were attenuated by TA.•TA may be a potential therapeutic option for the treatment of allergic asthma.
Asthma is a chronic inflammatory disease of the airways, which is characterized by infiltration of inflammatory cells, airway hyperresponsiveness (AHR), and airway remodeling. This study aimed to explore the role and mechanism of tannic acid (TA), a naturally occurring plant-derived polyphenol, in murine asthma model. BALB/c mice were given ovalbumin (OVA) to establish an allergic asthma model. The results revealed that TA treatment significantly decreased OVA-induced AHR, inflammatory cells infiltration, and the expression of various inflammatory mediators (Th2 and Th1 cytokines, eotaxin, and total IgE). Additionally, TA treatment also attenuated increases in mucins (Muc5ac and Muc5b) expression, mucus production in airway goblet cells, mast cells infiltration, and airway remodeling induced by OVA exposure. Furthermore, OVA-induced NF-κB (nuclear factor- kappa B) activation and cell adhesion molecules expression in the lungs was suppressed by TA treatment. In conclusion, TA effectively attenuated AHR, inflammatory response, and airway remodeling in OVA-challenged asthmatic mice. Therefore, TA may be a potential therapeutic option against allergic asthma in clinical settings.</description><identifier>ISSN: 1567-5769</identifier><identifier>EISSN: 1878-1705</identifier><identifier>DOI: 10.1016/j.intimp.2021.107847</identifier><identifier>PMID: 34126339</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Airway inflammation ; Airway Remodeling ; Allergens - immunology ; Animals ; Asthma ; Asthma - drug therapy ; Cell activation ; Cell adhesion ; Cell adhesion molecules ; Cytokines ; Disease Models, Animal ; Eotaxin ; Female ; Goblet cells ; Health services ; Humans ; Hypersensitivity - drug therapy ; Immunoglobulin E ; Infiltration ; Inflammatory diseases ; Inflammatory response ; Lymphocytes T ; Mast cells ; Mice ; Mucin ; Mucins ; Mucins - metabolism ; Natural compound ; NF-κB ; NF-κB protein ; Nuts ; Nuts - immunology ; Ovalbumin ; Plants ; Respiratory Hypersensitivity ; Respiratory tract ; Tannic acid ; Tannins - therapeutic use ; Th1 Cells ; Th2 Cells</subject><ispartof>International immunopharmacology, 2021-09, Vol.98, p.107847, Article 107847</ispartof><rights>2021 Elsevier B.V.</rights><rights>Copyright © 2021 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier BV Sep 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-479d6615ba18e06a6105aaff2f440de49bd3eac69c99cd2f096ebc9857019ac73</citedby><cites>FETCH-LOGICAL-c456t-479d6615ba18e06a6105aaff2f440de49bd3eac69c99cd2f096ebc9857019ac73</cites><orcidid>0000-0003-2303-3246 ; 0000-0003-0793-8440</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.intimp.2021.107847$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34126339$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rajasekar, Nandhine</creatorcontrib><creatorcontrib>Sivanantham, Ayyanar</creatorcontrib><creatorcontrib>Kar, Amrita</creatorcontrib><creatorcontrib>Mukhopadhyay, Sramana</creatorcontrib><creatorcontrib>Mahapatra, Santanu Kar</creatorcontrib><creatorcontrib>Paramasivam, Sudhakar Gandhi</creatorcontrib><creatorcontrib>Rajasekaran, Subbiah</creatorcontrib><title>Anti-asthmatic effects of tannic acid from Chinese natural gall nuts in a mouse model of allergic asthma</title><title>International immunopharmacology</title><addtitle>Int Immunopharmacol</addtitle><description>[Display omitted]
•Tannic acid (TA) is a class of polyphenol that is present in higher plants.•AHR and airway inflammation in OVA-induced asthmatic mice were suppressed by TA.•TA also reduced mast cell numbers and mucus hypersecretion.•OVA-induced airway remodeling and NF-kB activation were attenuated by TA.•TA may be a potential therapeutic option for the treatment of allergic asthma.
Asthma is a chronic inflammatory disease of the airways, which is characterized by infiltration of inflammatory cells, airway hyperresponsiveness (AHR), and airway remodeling. This study aimed to explore the role and mechanism of tannic acid (TA), a naturally occurring plant-derived polyphenol, in murine asthma model. BALB/c mice were given ovalbumin (OVA) to establish an allergic asthma model. The results revealed that TA treatment significantly decreased OVA-induced AHR, inflammatory cells infiltration, and the expression of various inflammatory mediators (Th2 and Th1 cytokines, eotaxin, and total IgE). Additionally, TA treatment also attenuated increases in mucins (Muc5ac and Muc5b) expression, mucus production in airway goblet cells, mast cells infiltration, and airway remodeling induced by OVA exposure. Furthermore, OVA-induced NF-κB (nuclear factor- kappa B) activation and cell adhesion molecules expression in the lungs was suppressed by TA treatment. In conclusion, TA effectively attenuated AHR, inflammatory response, and airway remodeling in OVA-challenged asthmatic mice. Therefore, TA may be a potential therapeutic option against allergic asthma in clinical settings.</description><subject>Airway inflammation</subject><subject>Airway Remodeling</subject><subject>Allergens - immunology</subject><subject>Animals</subject><subject>Asthma</subject><subject>Asthma - drug therapy</subject><subject>Cell activation</subject><subject>Cell adhesion</subject><subject>Cell adhesion molecules</subject><subject>Cytokines</subject><subject>Disease Models, Animal</subject><subject>Eotaxin</subject><subject>Female</subject><subject>Goblet cells</subject><subject>Health services</subject><subject>Humans</subject><subject>Hypersensitivity - drug therapy</subject><subject>Immunoglobulin E</subject><subject>Infiltration</subject><subject>Inflammatory diseases</subject><subject>Inflammatory response</subject><subject>Lymphocytes T</subject><subject>Mast cells</subject><subject>Mice</subject><subject>Mucin</subject><subject>Mucins</subject><subject>Mucins - metabolism</subject><subject>Natural compound</subject><subject>NF-κB</subject><subject>NF-κB protein</subject><subject>Nuts</subject><subject>Nuts - immunology</subject><subject>Ovalbumin</subject><subject>Plants</subject><subject>Respiratory Hypersensitivity</subject><subject>Respiratory tract</subject><subject>Tannic acid</subject><subject>Tannins - therapeutic use</subject><subject>Th1 Cells</subject><subject>Th2 Cells</subject><issn>1567-5769</issn><issn>1878-1705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYMoPkb_gUjAdcekTZNmI8jgCwbc6DpkkpuZDG06Jq3gvzdj1aWrhHPPOZf7IXRJyZwSym-2cx8G3-3mJSlplkTDxAE6pY1oCipIfZj_NRdFLbg8QWcpbQnJOqPH6KRitORVJU_R5i6XFDoNm04P3mBwDsyQcO_woEPIijbeYhf7Di82PkACHPQwRt3itW5bHMbs9gFr3PVjHna9hXYfz0OI633Bd_k5OnK6TXDx887Q28P96-KpWL48Pi_uloVhNR8KJqTlnNYrTRsgXHNKaq2dKx1jxAKTK1uBNlwaKY0tHZEcVkY2tSBUaiOqGbqeenexfx8hDWrbjzHklaqsBWtISQjPLja5TOxTiuDULvpOx09FidrjVVs14VV7vGrCm2NXP-XjqgP7F_rlmQ23kwHyiR8eokrGQzBgfcxcle39_xu-AO0vjcs</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Rajasekar, Nandhine</creator><creator>Sivanantham, Ayyanar</creator><creator>Kar, Amrita</creator><creator>Mukhopadhyay, Sramana</creator><creator>Mahapatra, Santanu Kar</creator><creator>Paramasivam, Sudhakar Gandhi</creator><creator>Rajasekaran, Subbiah</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0003-2303-3246</orcidid><orcidid>https://orcid.org/0000-0003-0793-8440</orcidid></search><sort><creationdate>202109</creationdate><title>Anti-asthmatic effects of tannic acid from Chinese natural gall nuts in a mouse model of allergic asthma</title><author>Rajasekar, Nandhine ; Sivanantham, Ayyanar ; Kar, Amrita ; Mukhopadhyay, Sramana ; Mahapatra, Santanu Kar ; Paramasivam, Sudhakar Gandhi ; Rajasekaran, Subbiah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-479d6615ba18e06a6105aaff2f440de49bd3eac69c99cd2f096ebc9857019ac73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Airway inflammation</topic><topic>Airway Remodeling</topic><topic>Allergens - immunology</topic><topic>Animals</topic><topic>Asthma</topic><topic>Asthma - drug therapy</topic><topic>Cell activation</topic><topic>Cell adhesion</topic><topic>Cell adhesion molecules</topic><topic>Cytokines</topic><topic>Disease Models, Animal</topic><topic>Eotaxin</topic><topic>Female</topic><topic>Goblet cells</topic><topic>Health services</topic><topic>Humans</topic><topic>Hypersensitivity - drug therapy</topic><topic>Immunoglobulin E</topic><topic>Infiltration</topic><topic>Inflammatory diseases</topic><topic>Inflammatory response</topic><topic>Lymphocytes T</topic><topic>Mast cells</topic><topic>Mice</topic><topic>Mucin</topic><topic>Mucins</topic><topic>Mucins - metabolism</topic><topic>Natural compound</topic><topic>NF-κB</topic><topic>NF-κB protein</topic><topic>Nuts</topic><topic>Nuts - immunology</topic><topic>Ovalbumin</topic><topic>Plants</topic><topic>Respiratory Hypersensitivity</topic><topic>Respiratory tract</topic><topic>Tannic acid</topic><topic>Tannins - therapeutic use</topic><topic>Th1 Cells</topic><topic>Th2 Cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rajasekar, Nandhine</creatorcontrib><creatorcontrib>Sivanantham, Ayyanar</creatorcontrib><creatorcontrib>Kar, Amrita</creatorcontrib><creatorcontrib>Mukhopadhyay, Sramana</creatorcontrib><creatorcontrib>Mahapatra, Santanu Kar</creatorcontrib><creatorcontrib>Paramasivam, Sudhakar Gandhi</creatorcontrib><creatorcontrib>Rajasekaran, Subbiah</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>International immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rajasekar, Nandhine</au><au>Sivanantham, Ayyanar</au><au>Kar, Amrita</au><au>Mukhopadhyay, Sramana</au><au>Mahapatra, Santanu Kar</au><au>Paramasivam, Sudhakar Gandhi</au><au>Rajasekaran, Subbiah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-asthmatic effects of tannic acid from Chinese natural gall nuts in a mouse model of allergic asthma</atitle><jtitle>International immunopharmacology</jtitle><addtitle>Int Immunopharmacol</addtitle><date>2021-09</date><risdate>2021</risdate><volume>98</volume><spage>107847</spage><pages>107847-</pages><artnum>107847</artnum><issn>1567-5769</issn><eissn>1878-1705</eissn><abstract>[Display omitted]
•Tannic acid (TA) is a class of polyphenol that is present in higher plants.•AHR and airway inflammation in OVA-induced asthmatic mice were suppressed by TA.•TA also reduced mast cell numbers and mucus hypersecretion.•OVA-induced airway remodeling and NF-kB activation were attenuated by TA.•TA may be a potential therapeutic option for the treatment of allergic asthma.
Asthma is a chronic inflammatory disease of the airways, which is characterized by infiltration of inflammatory cells, airway hyperresponsiveness (AHR), and airway remodeling. This study aimed to explore the role and mechanism of tannic acid (TA), a naturally occurring plant-derived polyphenol, in murine asthma model. BALB/c mice were given ovalbumin (OVA) to establish an allergic asthma model. The results revealed that TA treatment significantly decreased OVA-induced AHR, inflammatory cells infiltration, and the expression of various inflammatory mediators (Th2 and Th1 cytokines, eotaxin, and total IgE). Additionally, TA treatment also attenuated increases in mucins (Muc5ac and Muc5b) expression, mucus production in airway goblet cells, mast cells infiltration, and airway remodeling induced by OVA exposure. Furthermore, OVA-induced NF-κB (nuclear factor- kappa B) activation and cell adhesion molecules expression in the lungs was suppressed by TA treatment. In conclusion, TA effectively attenuated AHR, inflammatory response, and airway remodeling in OVA-challenged asthmatic mice. Therefore, TA may be a potential therapeutic option against allergic asthma in clinical settings.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>34126339</pmid><doi>10.1016/j.intimp.2021.107847</doi><orcidid>https://orcid.org/0000-0003-2303-3246</orcidid><orcidid>https://orcid.org/0000-0003-0793-8440</orcidid></addata></record> |
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| subjects | Airway inflammation Airway Remodeling Allergens - immunology Animals Asthma Asthma - drug therapy Cell activation Cell adhesion Cell adhesion molecules Cytokines Disease Models, Animal Eotaxin Female Goblet cells Health services Humans Hypersensitivity - drug therapy Immunoglobulin E Infiltration Inflammatory diseases Inflammatory response Lymphocytes T Mast cells Mice Mucin Mucins Mucins - metabolism Natural compound NF-κB NF-κB protein Nuts Nuts - immunology Ovalbumin Plants Respiratory Hypersensitivity Respiratory tract Tannic acid Tannins - therapeutic use Th1 Cells Th2 Cells |
| title | Anti-asthmatic effects of tannic acid from Chinese natural gall nuts in a mouse model of allergic asthma |
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