Intestinal mucormycosis initially identified by next‐generation sequencing of cell‐free DNA
Mucormycosis is a rare fungal infection that typically affects severely immunocompromised individuals, often resulting in significant morbidity and mortality. Although early and aggressive intervention is necessary to prevent poor outcomes, diagnosis of this infection remains difficult. We report th...
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| Veröffentlicht in: | Transplant infectious disease 2021-08, Vol.23 (4), p.n/a |
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| container_title | Transplant infectious disease |
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| creator | Martin‐Blais, Rachel Pathak, Saumya Fitzwater, Sean Dawson, David W. Sisk, Anthony E. Farmer, Douglas G. Venick, Robert Yeganeh, Nava |
| description | Mucormycosis is a rare fungal infection that typically affects severely immunocompromised individuals, often resulting in significant morbidity and mortality. Although early and aggressive intervention is necessary to prevent poor outcomes, diagnosis of this infection remains difficult. We report the first case, to our knowledge, of invasive gastrointestinal mucormycosis initially identified by next‐generation sequencing of cfDNA from the blood, and discuss the various benefits and challenges which come with new molecular diagnostic techniques. |
| doi_str_mv | 10.1111/tid.13656 |
| format | Article |
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Although early and aggressive intervention is necessary to prevent poor outcomes, diagnosis of this infection remains difficult. 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| ispartof | Transplant infectious disease, 2021-08, Vol.23 (4), p.n/a |
| issn | 1398-2273 1399-3062 |
| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | cell‐free DNA DNA sequencing Fungal infections Infections invasive fungal infection Morbidity Mucormycosis next‐generation sequencing transplant |
| title | Intestinal mucormycosis initially identified by next‐generation sequencing of cell‐free DNA |
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