Numerical simulations on the flow fields of dynamic axial compression columns in chromatography processes
Dynamic axial compression (DAC) columns are key elements in Simulated Moving Bed, which is a chromatography process in drug industry and chemical engineering. In this study, we apply the computational fluid dynamics (CFD) technique to analyze the flow fields in the DAC column and propose rules for d...
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| Veröffentlicht in: | Journal of physics. Conference series 2017-02, Vol.814 (1), p.12003 |
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| creator | Liang, Ru Chien Liu, Cheng Che Liang, Ming Tsai Chen, Jiann Lin |
| description | Dynamic axial compression (DAC) columns are key elements in Simulated Moving Bed, which is a chromatography process in drug industry and chemical engineering. In this study, we apply the computational fluid dynamics (CFD) technique to analyze the flow fields in the DAC column and propose rules for distributor design based on mass conservation in fluid dynamics. Computer aided design (CAD) is used in constructing the numerical 3D modelling for the mesh system. The laminar flow fields with Darcy's law to model the porous zone are governed by the Navier-Stokes equations and employed to describe the porous flow fields. Experimental works have been conducted as the benchmark for us to choose feasible porous parameters for CFD. Besides, numerical treatments are elaborated to avoid calculation divergence resulting from large source terms. Results show that CFD combined with CAD is a good approach to investigate detailed flow fields in DAC columns and the design for distributors is straightforward. |
| doi_str_mv | 10.1088/1742-6596/814/1/012003 |
| format | Article |
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In this study, we apply the computational fluid dynamics (CFD) technique to analyze the flow fields in the DAC column and propose rules for distributor design based on mass conservation in fluid dynamics. Computer aided design (CAD) is used in constructing the numerical 3D modelling for the mesh system. The laminar flow fields with Darcy's law to model the porous zone are governed by the Navier-Stokes equations and employed to describe the porous flow fields. Experimental works have been conducted as the benchmark for us to choose feasible porous parameters for CFD. Besides, numerical treatments are elaborated to avoid calculation divergence resulting from large source terms. 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| subjects | Axial compression CAD Chemical engineering Chromatography Computational fluid dynamics Computer aided design Distributors Divergence Finite element method Fluid dynamics Laminar flow Mathematical models Moving beds Physics Three dimensional models |
| title | Numerical simulations on the flow fields of dynamic axial compression columns in chromatography processes |
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