Hyperaccumulation of cadmium by scallop Chlamys farreri revealed by comparative transcriptome analysis
Cadmium (Cd) is a hazardous environmental contaminant, which has a serious effect on the ecosystem, food safety and human health. Scallop could accumulate high concentration of Cd from the environment and has been regarded as a Cd hyper-accumulator. In this work, we investigated the antioxidative de...
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| Veröffentlicht in: | Biometals 2020-12, Vol.33 (6), p.397-413 |
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| creator | Zhao, Yanfang Kang, Xuming Shang, Derong Ning, Jinsong Ding, Haiyan Zhai, Yuxiu Sheng, Xiaofeng |
| description | Cadmium (Cd) is a hazardous environmental contaminant, which has a serious effect on the ecosystem, food safety and human health. Scallop could accumulate high concentration of Cd from the environment and has been regarded as a Cd hyper-accumulator. In this work, we investigated the antioxidative defense, detoxification and transport of Cd in the kidneys of scallops by transcriptome analysis. A total of 598 differentially expressed genes including 387 up-regulated and 211 down-regulated ones were obtained during Cd exposure, and 46 up-regulated and 260 down-regulated ones were obtained during depuration. Cadmium exposure could cause oxidative stress in the kidneys, which was particularly shown in the pathways involved in proteasome and oxidative phosphorylation. The mRNA expression of 5 metallothionein (MT) genes were overexpressed under Cd exposure and significantly decreased during Cd depuration, which played a vital role in Cd chelation and detoxification. The expression of divalent metal transporter (DMT) genes were down-regulated insignificantly during accumulation and depuration of Cd, which suggested that the DMT played little roles in Cd transport in scallops. A positive relationship in the expression of the zinc transporter (ZIP6 and ZIP1) genes with Cd exposure and depuration was observed, which confirmed its important role for Cd uptake in the kidneys of scallops. 26S proteasome activities and MT expression were Cd-dependent. This study supplied the important reference on the hyperaccumulation of Cd by scallops and identified some effective bioindicators for the environmental risk assessment. |
| doi_str_mv | 10.1007/s10534-020-00257-x |
| format | Article |
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Scallop could accumulate high concentration of Cd from the environment and has been regarded as a Cd hyper-accumulator. In this work, we investigated the antioxidative defense, detoxification and transport of Cd in the kidneys of scallops by transcriptome analysis. A total of 598 differentially expressed genes including 387 up-regulated and 211 down-regulated ones were obtained during Cd exposure, and 46 up-regulated and 260 down-regulated ones were obtained during depuration. Cadmium exposure could cause oxidative stress in the kidneys, which was particularly shown in the pathways involved in proteasome and oxidative phosphorylation. The mRNA expression of 5 metallothionein (MT) genes were overexpressed under Cd exposure and significantly decreased during Cd depuration, which played a vital role in Cd chelation and detoxification. The expression of divalent metal transporter (DMT) genes were down-regulated insignificantly during accumulation and depuration of Cd, which suggested that the DMT played little roles in Cd transport in scallops. A positive relationship in the expression of the zinc transporter (ZIP6 and ZIP1) genes with Cd exposure and depuration was observed, which confirmed its important role for Cd uptake in the kidneys of scallops. 26S proteasome activities and MT expression were Cd-dependent. This study supplied the important reference on the hyperaccumulation of Cd by scallops and identified some effective bioindicators for the environmental risk assessment.</description><identifier>ISSN: 0966-0844</identifier><identifier>EISSN: 1572-8773</identifier><identifier>DOI: 10.1007/s10534-020-00257-x</identifier><identifier>PMID: 33011849</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Animals ; Bioaccumulation ; Biochemistry ; Bioindicators ; Biomedical and Life Sciences ; Biomonitoring ; Cadmium ; Cadmium - metabolism ; Cell Biology ; Chelation ; Contaminants ; Depuration ; Detoxification ; Divalent metal transporter-1 ; Environmental assessment ; Environmental risk ; Exposure ; Food safety ; Gene expression ; Gene Expression Profiling ; Genes ; Indicator species ; Kidneys ; Life Sciences ; Medicine/Public Health ; Metallothionein ; Metallothionein - genetics ; Metallothionein - metabolism ; Microbiology ; Oxidative phosphorylation ; Oxidative stress ; Pectinidae - genetics ; Pectinidae - metabolism ; Pharmacology/Toxicology ; Phosphorylation ; Plant Physiology ; Proteasome 26S ; Risk assessment ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Scallops ; Transcriptomes ; Zinc transporter</subject><ispartof>Biometals, 2020-12, Vol.33 (6), p.397-413</ispartof><rights>Springer Nature B.V. 2020</rights><rights>Springer Nature B.V. 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c290x-165805fa97091870ea02feed65442d4ce04482cf22ee372f5fa59e2ea33dc6d3</citedby><cites>FETCH-LOGICAL-c290x-165805fa97091870ea02feed65442d4ce04482cf22ee372f5fa59e2ea33dc6d3</cites><orcidid>0000-0001-5912-7493</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10534-020-00257-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10534-020-00257-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33011849$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Yanfang</creatorcontrib><creatorcontrib>Kang, Xuming</creatorcontrib><creatorcontrib>Shang, Derong</creatorcontrib><creatorcontrib>Ning, Jinsong</creatorcontrib><creatorcontrib>Ding, Haiyan</creatorcontrib><creatorcontrib>Zhai, Yuxiu</creatorcontrib><creatorcontrib>Sheng, Xiaofeng</creatorcontrib><title>Hyperaccumulation of cadmium by scallop Chlamys farreri revealed by comparative transcriptome analysis</title><title>Biometals</title><addtitle>Biometals</addtitle><addtitle>Biometals</addtitle><description>Cadmium (Cd) is a hazardous environmental contaminant, which has a serious effect on the ecosystem, food safety and human health. Scallop could accumulate high concentration of Cd from the environment and has been regarded as a Cd hyper-accumulator. In this work, we investigated the antioxidative defense, detoxification and transport of Cd in the kidneys of scallops by transcriptome analysis. A total of 598 differentially expressed genes including 387 up-regulated and 211 down-regulated ones were obtained during Cd exposure, and 46 up-regulated and 260 down-regulated ones were obtained during depuration. Cadmium exposure could cause oxidative stress in the kidneys, which was particularly shown in the pathways involved in proteasome and oxidative phosphorylation. The mRNA expression of 5 metallothionein (MT) genes were overexpressed under Cd exposure and significantly decreased during Cd depuration, which played a vital role in Cd chelation and detoxification. The expression of divalent metal transporter (DMT) genes were down-regulated insignificantly during accumulation and depuration of Cd, which suggested that the DMT played little roles in Cd transport in scallops. A positive relationship in the expression of the zinc transporter (ZIP6 and ZIP1) genes with Cd exposure and depuration was observed, which confirmed its important role for Cd uptake in the kidneys of scallops. 26S proteasome activities and MT expression were Cd-dependent. This study supplied the important reference on the hyperaccumulation of Cd by scallops and identified some effective bioindicators for the environmental risk assessment.</description><subject>Animals</subject><subject>Bioaccumulation</subject><subject>Biochemistry</subject><subject>Bioindicators</subject><subject>Biomedical and Life Sciences</subject><subject>Biomonitoring</subject><subject>Cadmium</subject><subject>Cadmium - metabolism</subject><subject>Cell Biology</subject><subject>Chelation</subject><subject>Contaminants</subject><subject>Depuration</subject><subject>Detoxification</subject><subject>Divalent metal transporter-1</subject><subject>Environmental assessment</subject><subject>Environmental risk</subject><subject>Exposure</subject><subject>Food safety</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Genes</subject><subject>Indicator species</subject><subject>Kidneys</subject><subject>Life Sciences</subject><subject>Medicine/Public Health</subject><subject>Metallothionein</subject><subject>Metallothionein - genetics</subject><subject>Metallothionein - metabolism</subject><subject>Microbiology</subject><subject>Oxidative phosphorylation</subject><subject>Oxidative stress</subject><subject>Pectinidae - genetics</subject><subject>Pectinidae - metabolism</subject><subject>Pharmacology/Toxicology</subject><subject>Phosphorylation</subject><subject>Plant Physiology</subject><subject>Proteasome 26S</subject><subject>Risk assessment</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Scallops</subject><subject>Transcriptomes</subject><subject>Zinc 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Basic</collection><jtitle>Biometals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Yanfang</au><au>Kang, Xuming</au><au>Shang, Derong</au><au>Ning, Jinsong</au><au>Ding, Haiyan</au><au>Zhai, Yuxiu</au><au>Sheng, Xiaofeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperaccumulation of cadmium by scallop Chlamys farreri revealed by comparative transcriptome analysis</atitle><jtitle>Biometals</jtitle><stitle>Biometals</stitle><addtitle>Biometals</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>33</volume><issue>6</issue><spage>397</spage><epage>413</epage><pages>397-413</pages><issn>0966-0844</issn><eissn>1572-8773</eissn><abstract>Cadmium (Cd) is a hazardous environmental contaminant, which has a serious effect on the ecosystem, food safety and human health. Scallop could accumulate high concentration of Cd from the environment and has been regarded as a Cd hyper-accumulator. In this work, we investigated the antioxidative defense, detoxification and transport of Cd in the kidneys of scallops by transcriptome analysis. A total of 598 differentially expressed genes including 387 up-regulated and 211 down-regulated ones were obtained during Cd exposure, and 46 up-regulated and 260 down-regulated ones were obtained during depuration. Cadmium exposure could cause oxidative stress in the kidneys, which was particularly shown in the pathways involved in proteasome and oxidative phosphorylation. The mRNA expression of 5 metallothionein (MT) genes were overexpressed under Cd exposure and significantly decreased during Cd depuration, which played a vital role in Cd chelation and detoxification. The expression of divalent metal transporter (DMT) genes were down-regulated insignificantly during accumulation and depuration of Cd, which suggested that the DMT played little roles in Cd transport in scallops. A positive relationship in the expression of the zinc transporter (ZIP6 and ZIP1) genes with Cd exposure and depuration was observed, which confirmed its important role for Cd uptake in the kidneys of scallops. 26S proteasome activities and MT expression were Cd-dependent. This study supplied the important reference on the hyperaccumulation of Cd by scallops and identified some effective bioindicators for the environmental risk assessment.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>33011849</pmid><doi>10.1007/s10534-020-00257-x</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0001-5912-7493</orcidid></addata></record> |
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| subjects | Animals Bioaccumulation Biochemistry Bioindicators Biomedical and Life Sciences Biomonitoring Cadmium Cadmium - metabolism Cell Biology Chelation Contaminants Depuration Detoxification Divalent metal transporter-1 Environmental assessment Environmental risk Exposure Food safety Gene expression Gene Expression Profiling Genes Indicator species Kidneys Life Sciences Medicine/Public Health Metallothionein Metallothionein - genetics Metallothionein - metabolism Microbiology Oxidative phosphorylation Oxidative stress Pectinidae - genetics Pectinidae - metabolism Pharmacology/Toxicology Phosphorylation Plant Physiology Proteasome 26S Risk assessment RNA, Messenger - genetics RNA, Messenger - metabolism Scallops Transcriptomes Zinc transporter |
| title | Hyperaccumulation of cadmium by scallop Chlamys farreri revealed by comparative transcriptome analysis |
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