A binuclear iron(III) complex of 5,5′-dimethyl-2,2′-bipyridine as cytotoxic agent
The binuclear iron(III) complex ( 1 ), namely, {[Fe(5,5′-dmbpy) 2 (OH 2) ] 2 (µ-O)}(NO 3 ) 4 with a distorted octahedral coordination, formed by four nitrogen and two oxygen atoms, was previously reported by our team. In this study the DNA-binding and cytotoxicity evaluation for target complex were...
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| Veröffentlicht in: | Biometals 2020-12, Vol.33 (6), p.365-378 |
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| creator | Kondori, Tahere Akbarzadeh-T, Niloufar Ghaznavi, Habib Karimi, Zeinab Shahraki, Jafar Sheervalilou, Roghayeh Shahraki, Omolbanin |
| description | The binuclear iron(III) complex (
1
), namely, {[Fe(5,5′-dmbpy)
2
(OH
2)
]
2
(µ-O)}(NO
3
)
4
with a distorted octahedral coordination, formed by four nitrogen and two oxygen atoms, was previously reported by our team. In this study the DNA-binding and cytotoxicity evaluation for target complex were studied. The results indicated strong cytotoxicity activity against A549 cells comparable to cisplatin values. The binding interaction between complex
1
and FS-DNA was investigated by UV–Vis, fluorescence spectroscopy, and gel electrophoresis at physiological pH (7.2). The DNA binding investigation has shown groove binding interactions with complex
1
, therefore the hydrogen binding plays an important role in the interaction of DNA with complex
1
. The calculated thermodynamic parameters (ΔH°, ΔS° and ΔG°) show that hydrogen bonding and Vander–Waals forces have an important function in Fe(III) complex–DNA interaction. Moreover, DNA cleavage was studied using agarose gel electrophoresis. Viscosity measurements illustrated that relative viscosity of DNA was unchanged with the adding concentrations of Fe(III) complex. Molecular docking simulation results confirmed the spectroscopic and viscosity titration outcomes.
Graphic abstract |
| doi_str_mv | 10.1007/s10534-020-00255-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2573636926</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2573636926</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-cdfa2df02848998837f71ed6484deadd7df1a362c44abd6dad7f51cff377f313</originalsourceid><addsrcrecordid>eNp9kMtKAzEUhoMotlZfwIUMuFFo9CSZJDPLUrwUCm7qOqS51CntTE2m4HTlM_lIPolTW3Xn6nA43_8f-BA6J3BDAORtJMBZioECBqCc480B6hIuKc6kZIeoC7kQGLI07aCTGOcAkEsQx6jDGDCW57SLngfJtCjXZuF0SIpQlVej0eg6MdVytXBvSeUT3uef7x_YFktXvzQLTPt0u0-LVRMKW5Qu0TExTV3V1VthEj1zZX2KjrxeRHe2nz00ub-bDB_x-OlhNByMsWGS19hYr6n1QLM0y_MsY9JL4qxIs9Q6ba20nmgmqElTPbXCais9J8Z7JqVnhPXQ5a52FarXtYu1mlfrULYfFeWSCSZyKlqK7igTqhiD82oViqUOjSKgtiLVTqRqRapvkWrThi721evp0tnfyI-5FmA7ILancubC3-9_ar8A-S5_3A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2573636926</pqid></control><display><type>article</type><title>A binuclear iron(III) complex of 5,5′-dimethyl-2,2′-bipyridine as cytotoxic agent</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Kondori, Tahere ; Akbarzadeh-T, Niloufar ; Ghaznavi, Habib ; Karimi, Zeinab ; Shahraki, Jafar ; Sheervalilou, Roghayeh ; Shahraki, Omolbanin</creator><creatorcontrib>Kondori, Tahere ; Akbarzadeh-T, Niloufar ; Ghaznavi, Habib ; Karimi, Zeinab ; Shahraki, Jafar ; Sheervalilou, Roghayeh ; Shahraki, Omolbanin</creatorcontrib><description>The binuclear iron(III) complex (
1
), namely, {[Fe(5,5′-dmbpy)
2
(OH
2)
]
2
(µ-O)}(NO
3
)
4
with a distorted octahedral coordination, formed by four nitrogen and two oxygen atoms, was previously reported by our team. In this study the DNA-binding and cytotoxicity evaluation for target complex were studied. The results indicated strong cytotoxicity activity against A549 cells comparable to cisplatin values. The binding interaction between complex
1
and FS-DNA was investigated by UV–Vis, fluorescence spectroscopy, and gel electrophoresis at physiological pH (7.2). The DNA binding investigation has shown groove binding interactions with complex
1
, therefore the hydrogen binding plays an important role in the interaction of DNA with complex
1
. The calculated thermodynamic parameters (ΔH°, ΔS° and ΔG°) show that hydrogen bonding and Vander–Waals forces have an important function in Fe(III) complex–DNA interaction. Moreover, DNA cleavage was studied using agarose gel electrophoresis. Viscosity measurements illustrated that relative viscosity of DNA was unchanged with the adding concentrations of Fe(III) complex. Molecular docking simulation results confirmed the spectroscopic and viscosity titration outcomes.
Graphic abstract</description><identifier>ISSN: 0966-0844</identifier><identifier>EISSN: 1572-8773</identifier><identifier>DOI: 10.1007/s10534-020-00255-z</identifier><identifier>PMID: 33033992</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>2,2'-Dipyridyl - analogs & derivatives ; 2,2'-Dipyridyl - chemistry ; 2,2'-Dipyridyl - pharmacology ; Animals ; Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Binding ; Binding Sites - drug effects ; Biochemistry ; Biomedical and Life Sciences ; Cell Biology ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Cisplatin ; Coordination Complexes - chemical synthesis ; Coordination Complexes - chemistry ; Coordination Complexes - pharmacology ; Cytotoxicity ; Deoxyribonucleic acid ; DNA ; DNA - chemistry ; DNA - drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Electrophoresis ; Ferric Compounds - chemistry ; Ferric Compounds - pharmacology ; Fishes ; Fluorescence ; Fluorescence spectroscopy ; Gel electrophoresis ; Grooves ; Humans ; Hydrogen bonding ; Iron ; Life Sciences ; Medicine/Public Health ; Microbiology ; Molecular docking ; Molecular Docking Simulation ; Molecular Structure ; Oxygen atoms ; Pharmacology/Toxicology ; Plant Physiology ; Thermodynamics ; Titration ; Toxicity ; Viscosity ; Viscosity measurement</subject><ispartof>Biometals, 2020-12, Vol.33 (6), p.365-378</ispartof><rights>Springer Nature B.V. 2020</rights><rights>Springer Nature B.V. 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-cdfa2df02848998837f71ed6484deadd7df1a362c44abd6dad7f51cff377f313</citedby><cites>FETCH-LOGICAL-c375t-cdfa2df02848998837f71ed6484deadd7df1a362c44abd6dad7f51cff377f313</cites><orcidid>0000-0002-1685-7274</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10534-020-00255-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10534-020-00255-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33033992$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kondori, Tahere</creatorcontrib><creatorcontrib>Akbarzadeh-T, Niloufar</creatorcontrib><creatorcontrib>Ghaznavi, Habib</creatorcontrib><creatorcontrib>Karimi, Zeinab</creatorcontrib><creatorcontrib>Shahraki, Jafar</creatorcontrib><creatorcontrib>Sheervalilou, Roghayeh</creatorcontrib><creatorcontrib>Shahraki, Omolbanin</creatorcontrib><title>A binuclear iron(III) complex of 5,5′-dimethyl-2,2′-bipyridine as cytotoxic agent</title><title>Biometals</title><addtitle>Biometals</addtitle><addtitle>Biometals</addtitle><description>The binuclear iron(III) complex (
1
), namely, {[Fe(5,5′-dmbpy)
2
(OH
2)
]
2
(µ-O)}(NO
3
)
4
with a distorted octahedral coordination, formed by four nitrogen and two oxygen atoms, was previously reported by our team. In this study the DNA-binding and cytotoxicity evaluation for target complex were studied. The results indicated strong cytotoxicity activity against A549 cells comparable to cisplatin values. The binding interaction between complex
1
and FS-DNA was investigated by UV–Vis, fluorescence spectroscopy, and gel electrophoresis at physiological pH (7.2). The DNA binding investigation has shown groove binding interactions with complex
1
, therefore the hydrogen binding plays an important role in the interaction of DNA with complex
1
. The calculated thermodynamic parameters (ΔH°, ΔS° and ΔG°) show that hydrogen bonding and Vander–Waals forces have an important function in Fe(III) complex–DNA interaction. Moreover, DNA cleavage was studied using agarose gel electrophoresis. Viscosity measurements illustrated that relative viscosity of DNA was unchanged with the adding concentrations of Fe(III) complex. Molecular docking simulation results confirmed the spectroscopic and viscosity titration outcomes.
Graphic abstract</description><subject>2,2'-Dipyridyl - analogs & derivatives</subject><subject>2,2'-Dipyridyl - chemistry</subject><subject>2,2'-Dipyridyl - pharmacology</subject><subject>Animals</subject><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Binding</subject><subject>Binding Sites - drug effects</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cell Biology</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Cisplatin</subject><subject>Coordination Complexes - chemical synthesis</subject><subject>Coordination Complexes - chemistry</subject><subject>Coordination Complexes - pharmacology</subject><subject>Cytotoxicity</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA - chemistry</subject><subject>DNA - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Electrophoresis</subject><subject>Ferric Compounds - chemistry</subject><subject>Ferric Compounds - pharmacology</subject><subject>Fishes</subject><subject>Fluorescence</subject><subject>Fluorescence spectroscopy</subject><subject>Gel electrophoresis</subject><subject>Grooves</subject><subject>Humans</subject><subject>Hydrogen bonding</subject><subject>Iron</subject><subject>Life Sciences</subject><subject>Medicine/Public Health</subject><subject>Microbiology</subject><subject>Molecular docking</subject><subject>Molecular Docking Simulation</subject><subject>Molecular Structure</subject><subject>Oxygen atoms</subject><subject>Pharmacology/Toxicology</subject><subject>Plant Physiology</subject><subject>Thermodynamics</subject><subject>Titration</subject><subject>Toxicity</subject><subject>Viscosity</subject><subject>Viscosity measurement</subject><issn>0966-0844</issn><issn>1572-8773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kMtKAzEUhoMotlZfwIUMuFFo9CSZJDPLUrwUCm7qOqS51CntTE2m4HTlM_lIPolTW3Xn6nA43_8f-BA6J3BDAORtJMBZioECBqCc480B6hIuKc6kZIeoC7kQGLI07aCTGOcAkEsQx6jDGDCW57SLngfJtCjXZuF0SIpQlVej0eg6MdVytXBvSeUT3uef7x_YFktXvzQLTPt0u0-LVRMKW5Qu0TExTV3V1VthEj1zZX2KjrxeRHe2nz00ub-bDB_x-OlhNByMsWGS19hYr6n1QLM0y_MsY9JL4qxIs9Q6ba20nmgmqElTPbXCais9J8Z7JqVnhPXQ5a52FarXtYu1mlfrULYfFeWSCSZyKlqK7igTqhiD82oViqUOjSKgtiLVTqRqRapvkWrThi721evp0tnfyI-5FmA7ILancubC3-9_ar8A-S5_3A</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Kondori, Tahere</creator><creator>Akbarzadeh-T, Niloufar</creator><creator>Ghaznavi, Habib</creator><creator>Karimi, Zeinab</creator><creator>Shahraki, Jafar</creator><creator>Sheervalilou, Roghayeh</creator><creator>Shahraki, Omolbanin</creator><general>Springer Netherlands</general><general>Springer Nature 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binuclear iron(III) complex of 5,5′-dimethyl-2,2′-bipyridine as cytotoxic agent</title><author>Kondori, Tahere ; Akbarzadeh-T, Niloufar ; Ghaznavi, Habib ; Karimi, Zeinab ; Shahraki, Jafar ; Sheervalilou, Roghayeh ; Shahraki, Omolbanin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-cdfa2df02848998837f71ed6484deadd7df1a362c44abd6dad7f51cff377f313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>2,2'-Dipyridyl - analogs & derivatives</topic><topic>2,2'-Dipyridyl - chemistry</topic><topic>2,2'-Dipyridyl - pharmacology</topic><topic>Animals</topic><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Binding</topic><topic>Binding Sites - drug effects</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Cell Biology</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Cisplatin</topic><topic>Coordination Complexes - chemical synthesis</topic><topic>Coordination Complexes - chemistry</topic><topic>Coordination Complexes - pharmacology</topic><topic>Cytotoxicity</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA - chemistry</topic><topic>DNA - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Electrophoresis</topic><topic>Ferric Compounds - chemistry</topic><topic>Ferric Compounds - pharmacology</topic><topic>Fishes</topic><topic>Fluorescence</topic><topic>Fluorescence spectroscopy</topic><topic>Gel electrophoresis</topic><topic>Grooves</topic><topic>Humans</topic><topic>Hydrogen bonding</topic><topic>Iron</topic><topic>Life Sciences</topic><topic>Medicine/Public Health</topic><topic>Microbiology</topic><topic>Molecular docking</topic><topic>Molecular Docking 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agent</atitle><jtitle>Biometals</jtitle><stitle>Biometals</stitle><addtitle>Biometals</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>33</volume><issue>6</issue><spage>365</spage><epage>378</epage><pages>365-378</pages><issn>0966-0844</issn><eissn>1572-8773</eissn><abstract>The binuclear iron(III) complex (
1
), namely, {[Fe(5,5′-dmbpy)
2
(OH
2)
]
2
(µ-O)}(NO
3
)
4
with a distorted octahedral coordination, formed by four nitrogen and two oxygen atoms, was previously reported by our team. In this study the DNA-binding and cytotoxicity evaluation for target complex were studied. The results indicated strong cytotoxicity activity against A549 cells comparable to cisplatin values. The binding interaction between complex
1
and FS-DNA was investigated by UV–Vis, fluorescence spectroscopy, and gel electrophoresis at physiological pH (7.2). The DNA binding investigation has shown groove binding interactions with complex
1
, therefore the hydrogen binding plays an important role in the interaction of DNA with complex
1
. The calculated thermodynamic parameters (ΔH°, ΔS° and ΔG°) show that hydrogen bonding and Vander–Waals forces have an important function in Fe(III) complex–DNA interaction. Moreover, DNA cleavage was studied using agarose gel electrophoresis. Viscosity measurements illustrated that relative viscosity of DNA was unchanged with the adding concentrations of Fe(III) complex. Molecular docking simulation results confirmed the spectroscopic and viscosity titration outcomes.
Graphic abstract</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>33033992</pmid><doi>10.1007/s10534-020-00255-z</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-1685-7274</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0966-0844 |
| ispartof | Biometals, 2020-12, Vol.33 (6), p.365-378 |
| issn | 0966-0844 1572-8773 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | 2,2'-Dipyridyl - analogs & derivatives 2,2'-Dipyridyl - chemistry 2,2'-Dipyridyl - pharmacology Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Binding Binding Sites - drug effects Biochemistry Biomedical and Life Sciences Cell Biology Cell Line, Tumor Cell Proliferation - drug effects Cisplatin Coordination Complexes - chemical synthesis Coordination Complexes - chemistry Coordination Complexes - pharmacology Cytotoxicity Deoxyribonucleic acid DNA DNA - chemistry DNA - drug effects Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Electrophoresis Ferric Compounds - chemistry Ferric Compounds - pharmacology Fishes Fluorescence Fluorescence spectroscopy Gel electrophoresis Grooves Humans Hydrogen bonding Iron Life Sciences Medicine/Public Health Microbiology Molecular docking Molecular Docking Simulation Molecular Structure Oxygen atoms Pharmacology/Toxicology Plant Physiology Thermodynamics Titration Toxicity Viscosity Viscosity measurement |
| title | A binuclear iron(III) complex of 5,5′-dimethyl-2,2′-bipyridine as cytotoxic agent |
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