Synthesis of Indoles by Reductive Cyclization of Nitro Compounds Using Formate Esters as CO Surrogates

Alkyl and aryl formate esters were evaluated as CO sources in the Pd‐ and Pd/Ru‐catalyzed reductive cyclization of 2‐nitrostyrenes to give indoles. Whereas the use of alkyl formates requires the presence of a ruthenium catalyst such as Ru3(CO)12, the reaction with phenyl formate can be performed by...

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Veröffentlicht in:	European journal of organic chemistry 2021-09, Vol.2021 (34), p.4876-4894
Hauptverfasser:	Ahmed Fouad, Manar, Ferretti, Francesco, Formenti, Dario, Milani, Fabio, Ragaini, Fabio
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbon monoxide Catalysts CO Source C−H Amination Formate esters Functional groups Indoles Nitro compounds Nitrogen heterocycles Palladium Phenyl Formate Ruthenium
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