Recent progress of oridonin and its derivatives for cancer therapy and drug resistance
Numerous antitumor drugs exhibited excellent anti-proliferation activities, discovered from natural products. Oridonin is isolated from a traditional Chinese medicine Isodon rubescens , and it exhibit various biological functions including anticancer, anti-inflammation, antibacterial, and so on. The...
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| Veröffentlicht in: | Medicinal chemistry research 2021-10, Vol.30 (10), p.1795-1821 |
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| creator | Guan, Yong-Feng Liu, Xiu-Juan Pang, Xiao-Jing Liu, Wen-Bo Yu, Guang -Xi Li, Yin -Ru Zhang, Yan-Bing Song, Jian Zhang, Sai-Yang |
| description | Numerous antitumor drugs exhibited excellent anti-proliferation activities, discovered from natural products. Oridonin is isolated from a traditional Chinese medicine
Isodon rubescens
, and it exhibit various biological functions including anticancer, anti-inflammation, antibacterial, and so on. The anticancer mechanisms of oridonin include apoptosis, autophagy, cell cycle arrest, and so on. However, clinical research and application of oridonin has been hampered, due to the poor pharmaceutical property. So many studies on oridonin have been explored in the purpose of improve the pharmaceutical property, including investigation of the mechanism of action in depth and structural modification. In this review, we summarized oridonin and oridonin derivatives as potential anticancer agents, and detailed discussion on biological properties, mechanism of actions and potential for overcoming therapeutic resistance. |
| doi_str_mv | 10.1007/s00044-021-02779-6 |
| format | Article |
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Isodon rubescens
, and it exhibit various biological functions including anticancer, anti-inflammation, antibacterial, and so on. The anticancer mechanisms of oridonin include apoptosis, autophagy, cell cycle arrest, and so on. However, clinical research and application of oridonin has been hampered, due to the poor pharmaceutical property. So many studies on oridonin have been explored in the purpose of improve the pharmaceutical property, including investigation of the mechanism of action in depth and structural modification. In this review, we summarized oridonin and oridonin derivatives as potential anticancer agents, and detailed discussion on biological properties, mechanism of actions and potential for overcoming therapeutic resistance.</description><identifier>ISSN: 1054-2523</identifier><identifier>EISSN: 1554-8120</identifier><identifier>DOI: 10.1007/s00044-021-02779-6</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Anticancer properties ; Antiinfectives and antibacterials ; Antitumor agents ; Apoptosis ; Autophagy ; Biochemistry ; Biological properties ; Biomedical and Life Sciences ; Biomedicine ; Bioorganic Chemistry ; Cancer ; Cancer therapies ; Cell cycle ; Drug resistance ; Inorganic Chemistry ; Medicinal Chemistry ; Natural products ; Phagocytosis ; Pharmaceuticals ; Pharmacology/Toxicology ; Review Article ; Traditional Chinese medicine</subject><ispartof>Medicinal chemistry research, 2021-10, Vol.30 (10), p.1795-1821</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-6a2b92612a17d6fca3f24c02a606a1ff39408e34e7a0c7ad7ae22b8b9b628cc03</citedby><cites>FETCH-LOGICAL-c385t-6a2b92612a17d6fca3f24c02a606a1ff39408e34e7a0c7ad7ae22b8b9b628cc03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00044-021-02779-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00044-021-02779-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids></links><search><creatorcontrib>Guan, Yong-Feng</creatorcontrib><creatorcontrib>Liu, Xiu-Juan</creatorcontrib><creatorcontrib>Pang, Xiao-Jing</creatorcontrib><creatorcontrib>Liu, Wen-Bo</creatorcontrib><creatorcontrib>Yu, Guang -Xi</creatorcontrib><creatorcontrib>Li, Yin -Ru</creatorcontrib><creatorcontrib>Zhang, Yan-Bing</creatorcontrib><creatorcontrib>Song, Jian</creatorcontrib><creatorcontrib>Zhang, Sai-Yang</creatorcontrib><title>Recent progress of oridonin and its derivatives for cancer therapy and drug resistance</title><title>Medicinal chemistry research</title><addtitle>Med Chem Res</addtitle><description>Numerous antitumor drugs exhibited excellent anti-proliferation activities, discovered from natural products. Oridonin is isolated from a traditional Chinese medicine
Isodon rubescens
, and it exhibit various biological functions including anticancer, anti-inflammation, antibacterial, and so on. The anticancer mechanisms of oridonin include apoptosis, autophagy, cell cycle arrest, and so on. However, clinical research and application of oridonin has been hampered, due to the poor pharmaceutical property. So many studies on oridonin have been explored in the purpose of improve the pharmaceutical property, including investigation of the mechanism of action in depth and structural modification. In this review, we summarized oridonin and oridonin derivatives as potential anticancer agents, and detailed discussion on biological properties, mechanism of actions and potential for overcoming therapeutic resistance.</description><subject>Anticancer properties</subject><subject>Antiinfectives and antibacterials</subject><subject>Antitumor agents</subject><subject>Apoptosis</subject><subject>Autophagy</subject><subject>Biochemistry</subject><subject>Biological properties</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bioorganic Chemistry</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Cell cycle</subject><subject>Drug resistance</subject><subject>Inorganic Chemistry</subject><subject>Medicinal Chemistry</subject><subject>Natural products</subject><subject>Phagocytosis</subject><subject>Pharmaceuticals</subject><subject>Pharmacology/Toxicology</subject><subject>Review Article</subject><subject>Traditional Chinese medicine</subject><issn>1054-2523</issn><issn>1554-8120</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kE9LxDAQxYMouK5-AU8Bz9XJJE3aoyz-gwVB1GtI02Ttou2apAv77c1uBW8ehhmY994MP0IuGVwzAHUTAUCIApDlUqou5BGZsbIURcUQjvMMecYS-Sk5i3ENwBWIckbeX5x1faKbMKyCi5EOng6ha4e-66npW9qlSFsXuq1J3dZF6odAremtCzR9uGA2u4OsDeOK5oAupv3ynJx48xndxW-fk7f7u9fFY7F8fnha3C4Ly6syFdJgU6NkaJhqpbeGexQW0EiQhnnPawGV48IpA1aZVhmH2FRN3UisrAU-J1dTbv7_e3Qx6fUwhj6f1FgqrGUlKpZVOKlsGGIMzutN6L5M2GkGes9PT_x05qcP_LTMJj6ZYhb3Kxf-ov9x_QCjsXOq</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Guan, Yong-Feng</creator><creator>Liu, Xiu-Juan</creator><creator>Pang, Xiao-Jing</creator><creator>Liu, Wen-Bo</creator><creator>Yu, Guang -Xi</creator><creator>Li, Yin -Ru</creator><creator>Zhang, Yan-Bing</creator><creator>Song, Jian</creator><creator>Zhang, Sai-Yang</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope></search><sort><creationdate>20211001</creationdate><title>Recent progress of oridonin and its derivatives for cancer therapy and drug resistance</title><author>Guan, Yong-Feng ; Liu, Xiu-Juan ; Pang, Xiao-Jing ; Liu, Wen-Bo ; Yu, Guang -Xi ; Li, Yin -Ru ; Zhang, Yan-Bing ; Song, Jian ; Zhang, Sai-Yang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-6a2b92612a17d6fca3f24c02a606a1ff39408e34e7a0c7ad7ae22b8b9b628cc03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Anticancer properties</topic><topic>Antiinfectives and antibacterials</topic><topic>Antitumor agents</topic><topic>Apoptosis</topic><topic>Autophagy</topic><topic>Biochemistry</topic><topic>Biological properties</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bioorganic Chemistry</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Cell cycle</topic><topic>Drug resistance</topic><topic>Inorganic Chemistry</topic><topic>Medicinal Chemistry</topic><topic>Natural products</topic><topic>Phagocytosis</topic><topic>Pharmaceuticals</topic><topic>Pharmacology/Toxicology</topic><topic>Review Article</topic><topic>Traditional Chinese medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guan, Yong-Feng</creatorcontrib><creatorcontrib>Liu, Xiu-Juan</creatorcontrib><creatorcontrib>Pang, Xiao-Jing</creatorcontrib><creatorcontrib>Liu, Wen-Bo</creatorcontrib><creatorcontrib>Yu, Guang -Xi</creatorcontrib><creatorcontrib>Li, Yin -Ru</creatorcontrib><creatorcontrib>Zhang, Yan-Bing</creatorcontrib><creatorcontrib>Song, Jian</creatorcontrib><creatorcontrib>Zhang, Sai-Yang</creatorcontrib><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Medicinal chemistry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guan, Yong-Feng</au><au>Liu, Xiu-Juan</au><au>Pang, Xiao-Jing</au><au>Liu, Wen-Bo</au><au>Yu, Guang -Xi</au><au>Li, Yin -Ru</au><au>Zhang, Yan-Bing</au><au>Song, Jian</au><au>Zhang, Sai-Yang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recent progress of oridonin and its derivatives for cancer therapy and drug resistance</atitle><jtitle>Medicinal chemistry research</jtitle><stitle>Med Chem Res</stitle><date>2021-10-01</date><risdate>2021</risdate><volume>30</volume><issue>10</issue><spage>1795</spage><epage>1821</epage><pages>1795-1821</pages><issn>1054-2523</issn><eissn>1554-8120</eissn><abstract>Numerous antitumor drugs exhibited excellent anti-proliferation activities, discovered from natural products. Oridonin is isolated from a traditional Chinese medicine
Isodon rubescens
, and it exhibit various biological functions including anticancer, anti-inflammation, antibacterial, and so on. The anticancer mechanisms of oridonin include apoptosis, autophagy, cell cycle arrest, and so on. However, clinical research and application of oridonin has been hampered, due to the poor pharmaceutical property. So many studies on oridonin have been explored in the purpose of improve the pharmaceutical property, including investigation of the mechanism of action in depth and structural modification. In this review, we summarized oridonin and oridonin derivatives as potential anticancer agents, and detailed discussion on biological properties, mechanism of actions and potential for overcoming therapeutic resistance.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s00044-021-02779-6</doi><tpages>27</tpages></addata></record> |
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| subjects | Anticancer properties Antiinfectives and antibacterials Antitumor agents Apoptosis Autophagy Biochemistry Biological properties Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Cancer Cancer therapies Cell cycle Drug resistance Inorganic Chemistry Medicinal Chemistry Natural products Phagocytosis Pharmaceuticals Pharmacology/Toxicology Review Article Traditional Chinese medicine |
| title | Recent progress of oridonin and its derivatives for cancer therapy and drug resistance |
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