High leukotriene B4 serum levels increase risk of painful diabetic neuropathy among type 2 diabetes mellitus patients
Background Painful diabetic neuropathy is one of the most common complications of type 2 diabetes mellitus, with approximately 30–50% of people will experience diabetic neuropathy. Chronic hyperglycemia will cause an inflammatory process that will trigger an immune response included leukotrienes. Le...
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| Veröffentlicht in: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Psychiatry and Neurosurgery, 2021-09, Vol.57 (1), p.1-5, Article 125 |
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| creator | Yuwanda, Kelvin Widyadharma, I Putu Eka Samatra, Dewa Putu Gde Purwa Adnyana, I Made Oka Gelgel, Anna Marita Arimbawa, I Komang |
| description | Background
Painful diabetic neuropathy is one of the most common complications of type 2 diabetes mellitus, with approximately 30–50% of people will experience diabetic neuropathy. Chronic hyperglycemia will cause an inflammatory process that will trigger an immune response included leukotrienes. Leukotriene B4 is associated with hemoglobin glycation levels. This study aimed to determine high serum leukotriene B4 levels and other factors as a risk factor for painful diabetic neuropathy in type 2 diabetes mellitus patient.
Results
Forty-two subjects with 22 cases (median age 56.5 ± 4.9 years) and 20 controls (median age 56.5 ± 5.2 years) group were collected. In bivariate analysis, significant factor for high risk PDN was high leukotriene B4 serum level (OR 5.10; 95% CI 1.34–19.4,
p
0.014). Meanwhile, insignificant factors were anti-diabetic drugs (OR 2.139; 0.62–7.37;
p
= 0.226), and duration of diabetes mellitus (OR 2.282; 0.56–9.25;
p
= 0.315). Independent risk factor was serum leukotriene B4 levels (OR 5.10; 95% CI 1.336–19.470;
p
= 0.017).
Conclusions
In this study, high leukotriene B4 serum levels increase the risk of painful diabetic neuropathy among type 2 diabetes mellitus. The leukotriene B4 may consider as a potential biomarker for early detection in high risk for PDN and early treatment. |
| doi_str_mv | 10.1186/s41983-021-00375-4 |
| format | Article |
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Painful diabetic neuropathy is one of the most common complications of type 2 diabetes mellitus, with approximately 30–50% of people will experience diabetic neuropathy. Chronic hyperglycemia will cause an inflammatory process that will trigger an immune response included leukotrienes. Leukotriene B4 is associated with hemoglobin glycation levels. This study aimed to determine high serum leukotriene B4 levels and other factors as a risk factor for painful diabetic neuropathy in type 2 diabetes mellitus patient.
Results
Forty-two subjects with 22 cases (median age 56.5 ± 4.9 years) and 20 controls (median age 56.5 ± 5.2 years) group were collected. In bivariate analysis, significant factor for high risk PDN was high leukotriene B4 serum level (OR 5.10; 95% CI 1.34–19.4,
p
0.014). Meanwhile, insignificant factors were anti-diabetic drugs (OR 2.139; 0.62–7.37;
p
= 0.226), and duration of diabetes mellitus (OR 2.282; 0.56–9.25;
p
= 0.315). Independent risk factor was serum leukotriene B4 levels (OR 5.10; 95% CI 1.336–19.470;
p
= 0.017).
Conclusions
In this study, high leukotriene B4 serum levels increase the risk of painful diabetic neuropathy among type 2 diabetes mellitus. The leukotriene B4 may consider as a potential biomarker for early detection in high risk for PDN and early treatment.</description><identifier>ISSN: 1687-8329</identifier><identifier>ISSN: 1110-1083</identifier><identifier>EISSN: 1687-8329</identifier><identifier>DOI: 10.1186/s41983-021-00375-4</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Age ; Biomarkers ; Diabetes ; Diabetes mellitus ; Diabetic neuropathy ; Disease ; Drugs ; Hospitals ; Hyperglycemia ; Insulin ; Leukotriene B4 levels ; Medicine ; Medicine & Public Health ; Neurology ; Neurosurgery ; Pain ; Painful diabetic neuropathy ; Patients ; Psychiatry ; Risk factors</subject><ispartof>The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2021-09, Vol.57 (1), p.1-5, Article 125</ispartof><rights>The Author(s) 2021</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-389160850d3fcea367a32495c17fc2aa5e9d6342725cf670d32e74110b726e393</citedby><cites>FETCH-LOGICAL-c429t-389160850d3fcea367a32495c17fc2aa5e9d6342725cf670d32e74110b726e393</cites><orcidid>0000-0002-4554-0348</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids></links><search><creatorcontrib>Yuwanda, Kelvin</creatorcontrib><creatorcontrib>Widyadharma, I Putu Eka</creatorcontrib><creatorcontrib>Samatra, Dewa Putu Gde Purwa</creatorcontrib><creatorcontrib>Adnyana, I Made Oka</creatorcontrib><creatorcontrib>Gelgel, Anna Marita</creatorcontrib><creatorcontrib>Arimbawa, I Komang</creatorcontrib><title>High leukotriene B4 serum levels increase risk of painful diabetic neuropathy among type 2 diabetes mellitus patients</title><title>The Egyptian Journal of Neurology, Psychiatry and Neurosurgery</title><addtitle>Egypt J Neurol Psychiatry Neurosurg</addtitle><description>Background
Painful diabetic neuropathy is one of the most common complications of type 2 diabetes mellitus, with approximately 30–50% of people will experience diabetic neuropathy. Chronic hyperglycemia will cause an inflammatory process that will trigger an immune response included leukotrienes. Leukotriene B4 is associated with hemoglobin glycation levels. This study aimed to determine high serum leukotriene B4 levels and other factors as a risk factor for painful diabetic neuropathy in type 2 diabetes mellitus patient.
Results
Forty-two subjects with 22 cases (median age 56.5 ± 4.9 years) and 20 controls (median age 56.5 ± 5.2 years) group were collected. In bivariate analysis, significant factor for high risk PDN was high leukotriene B4 serum level (OR 5.10; 95% CI 1.34–19.4,
p
0.014). Meanwhile, insignificant factors were anti-diabetic drugs (OR 2.139; 0.62–7.37;
p
= 0.226), and duration of diabetes mellitus (OR 2.282; 0.56–9.25;
p
= 0.315). Independent risk factor was serum leukotriene B4 levels (OR 5.10; 95% CI 1.336–19.470;
p
= 0.017).
Conclusions
In this study, high leukotriene B4 serum levels increase the risk of painful diabetic neuropathy among type 2 diabetes mellitus. The leukotriene B4 may consider as a potential biomarker for early detection in high risk for PDN and early treatment.</description><subject>Age</subject><subject>Biomarkers</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetic neuropathy</subject><subject>Disease</subject><subject>Drugs</subject><subject>Hospitals</subject><subject>Hyperglycemia</subject><subject>Insulin</subject><subject>Leukotriene B4 levels</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurology</subject><subject>Neurosurgery</subject><subject>Pain</subject><subject>Painful diabetic neuropathy</subject><subject>Patients</subject><subject>Psychiatry</subject><subject>Risk factors</subject><issn>1687-8329</issn><issn>1110-1083</issn><issn>1687-8329</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNp9kUtP3TAQhaMKpCLgD7Cy1HWK349li1pAQmIDa8txxhdDbpzaTqX772sIall1NaPRd87M6HTdBcFfCdHysnBiNOsxJT3GTImef-pOiNSq14yaow_95-68lDhgTgnBypCTbr2Juyc0wfqSao4wA_rOUYG87tvwN0wFxdlncAVQjuUFpYAWF-ewTmiMboAaPZphzWlx9emA3D7NO1QPCyD6DkBBe5imWNfSpLXtqOWsOw5uKnD-Xk-7x58_Hq5u-rv769urb3e959TUnmlDJNYCjyx4cEwqxyg3whMVPHVOgBkl41RR4YNUDaOgeHttUFQCM-y0u918x-Se7ZLj3uWDTS7at0HKO-tye2ECOyhnwGgK4-C5FEErqrEGHogTVHrZvL5sXktOv1Yo1T6nNc_tfEuFajcYLGij6Eb5nErJEP5uJdi-pmW3tGxLy76lZXkTsU1UGjzvIP-z_o_qD170l7Y</recordid><startdate>20210915</startdate><enddate>20210915</enddate><creator>Yuwanda, Kelvin</creator><creator>Widyadharma, I Putu Eka</creator><creator>Samatra, Dewa Putu Gde Purwa</creator><creator>Adnyana, I Made Oka</creator><creator>Gelgel, Anna Marita</creator><creator>Arimbawa, I Komang</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><general>SpringerOpen</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M2M</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-4554-0348</orcidid></search><sort><creationdate>20210915</creationdate><title>High leukotriene B4 serum levels increase risk of painful diabetic neuropathy among type 2 diabetes mellitus patients</title><author>Yuwanda, Kelvin ; Widyadharma, I Putu Eka ; Samatra, Dewa Putu Gde Purwa ; Adnyana, I Made Oka ; Gelgel, Anna Marita ; Arimbawa, I Komang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-389160850d3fcea367a32495c17fc2aa5e9d6342725cf670d32e74110b726e393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Age</topic><topic>Biomarkers</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetic neuropathy</topic><topic>Disease</topic><topic>Drugs</topic><topic>Hospitals</topic><topic>Hyperglycemia</topic><topic>Insulin</topic><topic>Leukotriene B4 levels</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurology</topic><topic>Neurosurgery</topic><topic>Pain</topic><topic>Painful diabetic neuropathy</topic><topic>Patients</topic><topic>Psychiatry</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yuwanda, Kelvin</creatorcontrib><creatorcontrib>Widyadharma, I Putu Eka</creatorcontrib><creatorcontrib>Samatra, Dewa Putu Gde Purwa</creatorcontrib><creatorcontrib>Adnyana, I Made Oka</creatorcontrib><creatorcontrib>Gelgel, Anna Marita</creatorcontrib><creatorcontrib>Arimbawa, I Komang</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Psychology Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>The Egyptian Journal of Neurology, Psychiatry and Neurosurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yuwanda, Kelvin</au><au>Widyadharma, I Putu Eka</au><au>Samatra, Dewa Putu Gde Purwa</au><au>Adnyana, I Made Oka</au><au>Gelgel, Anna Marita</au><au>Arimbawa, I Komang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High leukotriene B4 serum levels increase risk of painful diabetic neuropathy among type 2 diabetes mellitus patients</atitle><jtitle>The Egyptian Journal of Neurology, Psychiatry and Neurosurgery</jtitle><stitle>Egypt J Neurol Psychiatry Neurosurg</stitle><date>2021-09-15</date><risdate>2021</risdate><volume>57</volume><issue>1</issue><spage>1</spage><epage>5</epage><pages>1-5</pages><artnum>125</artnum><issn>1687-8329</issn><issn>1110-1083</issn><eissn>1687-8329</eissn><abstract>Background
Painful diabetic neuropathy is one of the most common complications of type 2 diabetes mellitus, with approximately 30–50% of people will experience diabetic neuropathy. Chronic hyperglycemia will cause an inflammatory process that will trigger an immune response included leukotrienes. Leukotriene B4 is associated with hemoglobin glycation levels. This study aimed to determine high serum leukotriene B4 levels and other factors as a risk factor for painful diabetic neuropathy in type 2 diabetes mellitus patient.
Results
Forty-two subjects with 22 cases (median age 56.5 ± 4.9 years) and 20 controls (median age 56.5 ± 5.2 years) group were collected. In bivariate analysis, significant factor for high risk PDN was high leukotriene B4 serum level (OR 5.10; 95% CI 1.34–19.4,
p
0.014). Meanwhile, insignificant factors were anti-diabetic drugs (OR 2.139; 0.62–7.37;
p
= 0.226), and duration of diabetes mellitus (OR 2.282; 0.56–9.25;
p
= 0.315). Independent risk factor was serum leukotriene B4 levels (OR 5.10; 95% CI 1.336–19.470;
p
= 0.017).
Conclusions
In this study, high leukotriene B4 serum levels increase the risk of painful diabetic neuropathy among type 2 diabetes mellitus. The leukotriene B4 may consider as a potential biomarker for early detection in high risk for PDN and early treatment.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1186/s41983-021-00375-4</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-4554-0348</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Age Biomarkers Diabetes Diabetes mellitus Diabetic neuropathy Disease Drugs Hospitals Hyperglycemia Insulin Leukotriene B4 levels Medicine Medicine & Public Health Neurology Neurosurgery Pain Painful diabetic neuropathy Patients Psychiatry Risk factors |
| title | High leukotriene B4 serum levels increase risk of painful diabetic neuropathy among type 2 diabetes mellitus patients |
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