Metabolic Disease Programming: From Mitochondria to Epigenetics, Glucocorticoid Signalling and Beyond

Embryonic and foetal development are critical periods of development in which several environmental cues determine health and disease in adulthood. Maternal conditions and an unfavourable intrauterine environment impact foetal development and may programme the offspring for increased predisposition...

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Veröffentlicht in:	European journal of clinical investigation 2021-10, Vol.51 (10), p.e13625-n/a
Hauptverfasser:	Grilo, Luís F., Tocantins, Carolina, Diniz, Mariana S., Gomes, Rodrigo Mello, Oliveira, Paulo J., Matafome, Paulo, Pereira, Susana P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation ageing‐related disease Animals Children Chronic illnesses Developmental Origins of Health and Disease (DOHaD) developmental programming Disease Diseases Embryogenesis Environmental impact Epigenesis, Genetic Epigenetics Female Fetal Development - physiology Fetus - physiology Genetics Glucocorticoids Glucocorticoids - physiology Health risks Homeostasis Humans Intrauterine exposure malnutrition Metabolic Diseases - etiology Metabolic disorders metabolism Mitochondria Mitochondria - physiology Molecular modelling non‐communicable diseases Offspring Origins Oxidative stress Pregnancy - physiology Programming Signaling Therapeutic targets
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