A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease

Late-onset Alzheimer's disease is a prevalent age-related polygenic disease that accounts for 50-70% of dementia cases. Currently, only a fraction of the genetic variants underlying Alzheimer's disease have been identified. Here we show that increased sample sizes allowed identification of...

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Veröffentlicht in:	Nature genetics 2021-09, Vol.53 (9), p.1276-3
Hauptverfasser:	Wightman, Douglas P, Jansen, Iris E, Savage, Jeanne E, Shadrin, Alexey A, Bahrami, Shahram, Holland, Dominic, Rongve, Arvid, Børte, Sigrid, Winsvold, Bendik S, Martinsen, Amy E, Skogholt, Anne Heidi, Willer, Cristen, Bråthen, Geir, Bosnes, Ingunn, Nielsen, Jonas Bille, Fritsche, Lars G, Thomas, Laurent F, Pedersen, Linda M, Gabrielsen, Maiken E, Meisingset, Tore Wergeland, Zhou, Wei, Proitsi, Petroula, Dobson, Richard, Velayudhan, Latha, Sealock, Julia M, Pedersen, Nancy L, Reynolds, Chandra A, Karlsson, Ida K, Magnusson, Sigurdur, Stefansson, Hreinn, Thordardottir, Steinunn, Jonsson, Palmi V, Snaedal, Jon, Zettergren, Anna, Kern, Silke, Waern, Margda, Zetterberg, Henrik, Blennow, Kaj, Stordal, Eystein, Zwart, John-Anker, Selnes, Per, Saltvedt, Ingvild, Sando, Sigrid B, Ulstein, Ingun, Djurovic, Srdjan, Fladby, Tormod, Aarsland, Dag, Ripke, Stephan, Stefansson, Kari, Posthuma, Danielle, Aslibekyan, Stella, Babalola, Elizabeth, Bielenberg, Jessica, Bullis, Emily, Cameron, Briana, Coker, Daniella, Partida, Gabriel Cuellar, Dhamija, Devika, Das, Sayantan, Elson, Sarah L, Filshtein, Teresa, Fletez-Brant, Kipper, Fontanillas, Pierre, Freyman, Will, Gandhi, Pooja M, Hicks, Barry, Hinds, David A, Huber, Karen E, Jewett, Ethan M, Jiang, Yunxuan, Kleinman, Aaron, Kukar, Katelyn, Lane, Vanessa, Lin, Keng-Han, Lowe, Maya, Luff, Marie K, McCreight, Jennifer C, McIntyre, Matthew H, McManus, Kimberly F, Micheletti, Steven J, Moreno, Meghan E, Mountain, Joanna L, Mozaffari, Sahar V, Nandakumar, Priyanka, Noblin, Elizabeth S, O'Connell, Jared, Petrakovitz, Aaron A, Poznik, G David, Schumacher, Morgan, Shastri, Anjali J, Shelton, Janie F, Shi, Jingchunzi, Shringarpure, Suyash, Tian, Chao, Tran, Vinh, Tung, Joyce Y, Wang, Xin, Wang, Wei, Weldon, Catherine H, Wilton, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Alzheimer's disease Catabolism Datasets Dementia Dementia disorders Gene loci Genetic diversity Genetic variance Genome-wide association studies Genomes Immune system Meta-analysis Microglia Neurodegenerative diseases Proteins
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Beschreibung
Zusammenfassung:	Late-onset Alzheimer's disease is a prevalent age-related polygenic disease that accounts for 50-70% of dementia cases. Currently, only a fraction of the genetic variants underlying Alzheimer's disease have been identified. Here we show that increased sample sizes allowed identification of seven previously unidentified genetic loci contributing to Alzheimer's disease. This study highlights microglia, immune cells and protein catabolism as relevant to late-onset Alzheimer's disease, while identifying and prioritizing previously unidentified genes of potential interest. We anticipate that these results can be included in larger meta-analyses of Alzheimer's disease to identify further genetic variants that contribute to Alzheimer's pathology.
ISSN:	1061-4036 1546-1718
DOI:	10.1038/s41588-02T00921-z