Protective mechanisms of gallic acid on hepatorenal dysfunction of zearalenone treated rat
Zearalenone (ZEN) is a mycotoxin that contaminates crops worldwide and whose toxic adverse effects are well documented. This study aims to evaluate the protective effect of gallic acid (GA) against biochemical, oxidative, inflammatory, and pathological changes in ZEN treated rats’ hepatorenal system...
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| Veröffentlicht in: | Biológia 2021-10, Vol.76 (10), p.3123-3135 |
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| creator | Owumi, Solomon E. Najophe, Sarah E. Idowu, Temitope B. Nwozo, Sarah O. |
| description | Zearalenone (ZEN) is a mycotoxin that contaminates crops worldwide and whose toxic adverse effects are well documented. This study aims to evaluate the protective effect of gallic acid (GA) against biochemical, oxidative, inflammatory, and pathological changes in ZEN treated rats’ hepatorenal system. Wistar rats (n = 50; 150 ± 30 g) were randomly grouped into five cohorts (= 10) specifically: Control (rat chow); ZEN alone (100 µg/kg;
per os
), GA alone (40 mg/kg;
per os
), ZEN + GA1 (100 µg/kg + 20 mg/kg
per os
) and ZEN + GA2 (100 µg/kg + 40 mg/kg
per os
) and the study was for 28 successive days. Upon terminal sacrifice, biomarkers of hepatorenal function and oxidative stress were analyzed. An assessment of cytokine levels (IL-1β, IL-10) and histopathology of the liver and kidneys was also performed. Relative to the control, serum levels of urea, creatinine, and hepatic transaminases increased significantly
(p |
| doi_str_mv | 10.1007/s11756-021-00828-4 |
| format | Article |
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per os
), GA alone (40 mg/kg;
per os
), ZEN + GA1 (100 µg/kg + 20 mg/kg
per os
) and ZEN + GA2 (100 µg/kg + 40 mg/kg
per os
) and the study was for 28 successive days. Upon terminal sacrifice, biomarkers of hepatorenal function and oxidative stress were analyzed. An assessment of cytokine levels (IL-1β, IL-10) and histopathology of the liver and kidneys was also performed. Relative to the control, serum levels of urea, creatinine, and hepatic transaminases increased significantly
(p < 0.05)
in the ZEN alone group and reduced in groups co-treated with GA. ZEN treatment further resulted in decreases in the rat’s antioxidant status. The increase in the reactive oxygen and nitrogen species (RONS) and lipid peroxidation (LPO) levels caused by ZEN exposure was reduced by GA in a dose-dependent manner
(p < 0.05)
. Furthermore, ZEN-mediated increase in nitric oxide (NO), xanthine oxidase (XO), IL-1β, and myeloperoxidase (MPO) levels and suppression of IL-10 levels were reversed in the liver and kidney of GA co-treated rats. The extent of ZEN-mediated hepatorenal lesions was reduced in rats co-treated with GA. Our findings suggest that GA effectively abated biochemical, oxido-inflammatory and histological alteration caused by ZEN exposure, limiting ZEN toxicity and cellular damage in rats’ hepatic and renal tissues.</description><identifier>ISSN: 0006-3088</identifier><identifier>EISSN: 1336-9563</identifier><identifier>DOI: 10.1007/s11756-021-00828-4</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Antioxidants ; Biomarkers ; Biomedical and Life Sciences ; Cell Biology ; Creatinine ; Cytokines ; Gallic acid ; Histopathology ; IL-1β ; Inflammation ; Interleukin 10 ; Kidneys ; Life Sciences ; Lipid peroxidation ; Lipids ; Liver ; Microbiology ; Mycotoxins ; Nitric oxide ; Original Article ; Oxidative stress ; Peroxidase ; Peroxidation ; Plant Sciences ; Reactive nitrogen species ; Reactive oxygen species ; Serum levels ; Toxicity ; Urea ; Xanthine oxidase ; Zearalenone ; Zoology</subject><ispartof>Biológia, 2021-10, Vol.76 (10), p.3123-3135</ispartof><rights>Institute of Molecular Biology, Slovak Academy of Sciences 2021</rights><rights>Institute of Molecular Biology, Slovak Academy of Sciences 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-4e2bf6d36c6c4d98060df271f7c0cf2259592343a1eeed62fb69c0e919cc578c3</citedby><cites>FETCH-LOGICAL-c319t-4e2bf6d36c6c4d98060df271f7c0cf2259592343a1eeed62fb69c0e919cc578c3</cites><orcidid>0000-0002-4973-0376</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11756-021-00828-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11756-021-00828-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Owumi, Solomon E.</creatorcontrib><creatorcontrib>Najophe, Sarah E.</creatorcontrib><creatorcontrib>Idowu, Temitope B.</creatorcontrib><creatorcontrib>Nwozo, Sarah O.</creatorcontrib><title>Protective mechanisms of gallic acid on hepatorenal dysfunction of zearalenone treated rat</title><title>Biológia</title><addtitle>Biologia</addtitle><description>Zearalenone (ZEN) is a mycotoxin that contaminates crops worldwide and whose toxic adverse effects are well documented. This study aims to evaluate the protective effect of gallic acid (GA) against biochemical, oxidative, inflammatory, and pathological changes in ZEN treated rats’ hepatorenal system. Wistar rats (n = 50; 150 ± 30 g) were randomly grouped into five cohorts (= 10) specifically: Control (rat chow); ZEN alone (100 µg/kg;
per os
), GA alone (40 mg/kg;
per os
), ZEN + GA1 (100 µg/kg + 20 mg/kg
per os
) and ZEN + GA2 (100 µg/kg + 40 mg/kg
per os
) and the study was for 28 successive days. Upon terminal sacrifice, biomarkers of hepatorenal function and oxidative stress were analyzed. An assessment of cytokine levels (IL-1β, IL-10) and histopathology of the liver and kidneys was also performed. Relative to the control, serum levels of urea, creatinine, and hepatic transaminases increased significantly
(p < 0.05)
in the ZEN alone group and reduced in groups co-treated with GA. ZEN treatment further resulted in decreases in the rat’s antioxidant status. The increase in the reactive oxygen and nitrogen species (RONS) and lipid peroxidation (LPO) levels caused by ZEN exposure was reduced by GA in a dose-dependent manner
(p < 0.05)
. Furthermore, ZEN-mediated increase in nitric oxide (NO), xanthine oxidase (XO), IL-1β, and myeloperoxidase (MPO) levels and suppression of IL-10 levels were reversed in the liver and kidney of GA co-treated rats. The extent of ZEN-mediated hepatorenal lesions was reduced in rats co-treated with GA. Our findings suggest that GA effectively abated biochemical, oxido-inflammatory and histological alteration caused by ZEN exposure, limiting ZEN toxicity and cellular damage in rats’ hepatic and renal tissues.</description><subject>Antioxidants</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>Cell Biology</subject><subject>Creatinine</subject><subject>Cytokines</subject><subject>Gallic acid</subject><subject>Histopathology</subject><subject>IL-1β</subject><subject>Inflammation</subject><subject>Interleukin 10</subject><subject>Kidneys</subject><subject>Life Sciences</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Liver</subject><subject>Microbiology</subject><subject>Mycotoxins</subject><subject>Nitric oxide</subject><subject>Original Article</subject><subject>Oxidative stress</subject><subject>Peroxidase</subject><subject>Peroxidation</subject><subject>Plant Sciences</subject><subject>Reactive nitrogen species</subject><subject>Reactive oxygen species</subject><subject>Serum levels</subject><subject>Toxicity</subject><subject>Urea</subject><subject>Xanthine oxidase</subject><subject>Zearalenone</subject><subject>Zoology</subject><issn>0006-3088</issn><issn>1336-9563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kM1KAzEURoMoWKsv4CrgOnqTzGQmSyn-QUEXunET0sxNO2U6qUkq6NMbreDOVeByzkc4hJxzuOQAzVXivKkVA8EZQCtaVh2QCZdSMV0reUgmAKCYhLY9JicprQGqpgY-Ia9PMWR0uX9HukG3smOfNokGT5d2GHpHres7Gka6wq3NIeJoB9p9JL8bi1TuhfxEG-2AYxiR5og2Y0ejzafkyNsh4dnvOyUvtzfPs3s2f7x7mF3PmZNcZ1ahWHjVSeWUqzrdgoLOi4b7xoHzQtS61kJW0nJE7JTwC6UdoObaubppnZySi_3uNoa3HaZs1mEXyz-TEXVTBkCptlBiT7kYUorozTb2Gxs_DAfz3dDsG5rS0Pw0NFWR5F5KBR6XGP-m_7G-ADm0dXU</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Owumi, Solomon E.</creator><creator>Najophe, Sarah E.</creator><creator>Idowu, Temitope B.</creator><creator>Nwozo, Sarah O.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><orcidid>https://orcid.org/0000-0002-4973-0376</orcidid></search><sort><creationdate>20211001</creationdate><title>Protective mechanisms of gallic acid on hepatorenal dysfunction of zearalenone treated rat</title><author>Owumi, Solomon E. ; Najophe, Sarah E. ; Idowu, Temitope B. ; Nwozo, Sarah O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-4e2bf6d36c6c4d98060df271f7c0cf2259592343a1eeed62fb69c0e919cc578c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antioxidants</topic><topic>Biomarkers</topic><topic>Biomedical and Life Sciences</topic><topic>Cell Biology</topic><topic>Creatinine</topic><topic>Cytokines</topic><topic>Gallic acid</topic><topic>Histopathology</topic><topic>IL-1β</topic><topic>Inflammation</topic><topic>Interleukin 10</topic><topic>Kidneys</topic><topic>Life Sciences</topic><topic>Lipid peroxidation</topic><topic>Lipids</topic><topic>Liver</topic><topic>Microbiology</topic><topic>Mycotoxins</topic><topic>Nitric oxide</topic><topic>Original Article</topic><topic>Oxidative stress</topic><topic>Peroxidase</topic><topic>Peroxidation</topic><topic>Plant Sciences</topic><topic>Reactive nitrogen species</topic><topic>Reactive oxygen species</topic><topic>Serum levels</topic><topic>Toxicity</topic><topic>Urea</topic><topic>Xanthine oxidase</topic><topic>Zearalenone</topic><topic>Zoology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Owumi, Solomon E.</creatorcontrib><creatorcontrib>Najophe, Sarah E.</creatorcontrib><creatorcontrib>Idowu, Temitope B.</creatorcontrib><creatorcontrib>Nwozo, Sarah O.</creatorcontrib><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Biológia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Owumi, Solomon E.</au><au>Najophe, Sarah E.</au><au>Idowu, Temitope B.</au><au>Nwozo, Sarah O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective mechanisms of gallic acid on hepatorenal dysfunction of zearalenone treated rat</atitle><jtitle>Biológia</jtitle><stitle>Biologia</stitle><date>2021-10-01</date><risdate>2021</risdate><volume>76</volume><issue>10</issue><spage>3123</spage><epage>3135</epage><pages>3123-3135</pages><issn>0006-3088</issn><eissn>1336-9563</eissn><abstract>Zearalenone (ZEN) is a mycotoxin that contaminates crops worldwide and whose toxic adverse effects are well documented. This study aims to evaluate the protective effect of gallic acid (GA) against biochemical, oxidative, inflammatory, and pathological changes in ZEN treated rats’ hepatorenal system. Wistar rats (n = 50; 150 ± 30 g) were randomly grouped into five cohorts (= 10) specifically: Control (rat chow); ZEN alone (100 µg/kg;
per os
), GA alone (40 mg/kg;
per os
), ZEN + GA1 (100 µg/kg + 20 mg/kg
per os
) and ZEN + GA2 (100 µg/kg + 40 mg/kg
per os
) and the study was for 28 successive days. Upon terminal sacrifice, biomarkers of hepatorenal function and oxidative stress were analyzed. An assessment of cytokine levels (IL-1β, IL-10) and histopathology of the liver and kidneys was also performed. Relative to the control, serum levels of urea, creatinine, and hepatic transaminases increased significantly
(p < 0.05)
in the ZEN alone group and reduced in groups co-treated with GA. ZEN treatment further resulted in decreases in the rat’s antioxidant status. The increase in the reactive oxygen and nitrogen species (RONS) and lipid peroxidation (LPO) levels caused by ZEN exposure was reduced by GA in a dose-dependent manner
(p < 0.05)
. Furthermore, ZEN-mediated increase in nitric oxide (NO), xanthine oxidase (XO), IL-1β, and myeloperoxidase (MPO) levels and suppression of IL-10 levels were reversed in the liver and kidney of GA co-treated rats. The extent of ZEN-mediated hepatorenal lesions was reduced in rats co-treated with GA. Our findings suggest that GA effectively abated biochemical, oxido-inflammatory and histological alteration caused by ZEN exposure, limiting ZEN toxicity and cellular damage in rats’ hepatic and renal tissues.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s11756-021-00828-4</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-4973-0376</orcidid></addata></record> |
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| subjects | Antioxidants Biomarkers Biomedical and Life Sciences Cell Biology Creatinine Cytokines Gallic acid Histopathology IL-1β Inflammation Interleukin 10 Kidneys Life Sciences Lipid peroxidation Lipids Liver Microbiology Mycotoxins Nitric oxide Original Article Oxidative stress Peroxidase Peroxidation Plant Sciences Reactive nitrogen species Reactive oxygen species Serum levels Toxicity Urea Xanthine oxidase Zearalenone Zoology |
| title | Protective mechanisms of gallic acid on hepatorenal dysfunction of zearalenone treated rat |
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