Role of 23.4 Gy upfront whole-brain radiation therapy following high-dose methotrexate for primary central nervous system lymphoma: a comparative analysis of whole-brain radiation therapy versus no radiation therapy

Introduction We aimed to investigate the role of upfront whole-brain radiation therapy (RT), with a reduced dose of 23.4 Gy, following high-dose methotrexate (HD-MTX) in patients with primary central nervous system lymphoma (PCNSL). Methods We retrospectively reviewed 185 patients with PCNSL treated...

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Veröffentlicht in:	Journal of neuro-oncology 2021-09, Vol.154 (2), p.207-217
Hauptverfasser:	Kim, Nalee, Lim, Do Hoon, Yoon, Sang Eun, Kim, Seok Jin, Kim, Won Seog
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols Brain Brain Neoplasms - drug therapy Brain Neoplasms - radiotherapy Central Nervous System Central Nervous System Neoplasms - drug therapy Central Nervous System Neoplasms - radiotherapy Clinical Study Comparative analysis Cranial Irradiation Humans Lymphoma Lymphoma, Non-Hodgkin - drug therapy Medicine Medicine & Public Health Methotrexate Methotrexate - therapeutic use Nervous system Neurology Neurotoxicity Oncology Patients Radiation therapy Retrospective Studies Rituximab Rituximab - therapeutic use Stem cell transplantation
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