Loss of smarcad1a accelerates tumorigenesis of malignant peripheral nerve sheath tumors in zebrafish

Malignant peripheral nerve sheath tumors (MPNSTs) are a type of sarcoma that generally originates from Schwann cells. The prognosis for this type of malignancy is relatively poor due to complicated genetic alterations and the lack of specific targeted therapy. Chromosome fragment 4q22‐23 is frequent...

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Veröffentlicht in:	Genes chromosomes & cancer 2021-11, Vol.60 (11), p.743-761
Hauptverfasser:	Han, Han, Jiang, Guangzhen, Kumari, Rashmi, Silic, Martin R., Owens, Jake L., Hu, Chang‐Deng, Mittal, Suresh K., Zhang, GuangJun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone cancer Carcinogenesis - genetics Carcinogenesis - metabolism Chromatin Chromosome 4 CRISPR Danio rerio Deoxyribonucleic acid DNA DNA Breaks, Double-Stranded DNA damage DNA Repair Double-strand break repair Embryogenesis Gene dosage Gene expression Malignancy MPNST Mutants Neurofibrosarcoma - genetics Neurofibrosarcoma - metabolism Osteosarcoma p53 Protein Peripheral nerves Ribose Sarcoma Schwann cells SMARCAD1 smarcad1a tp53, DNA damage repair Tumor suppressor genes Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumorigenesis Tumors Zebrafish zebrafish, 4q22‐23
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