Psoriasis, Vitiligo, and Biologic Therapy: Case Report and Narrative Review

Psoriasis and vitiligo are 2 multifactorial immune-mediated diseases, partially sharing pathogenetic underpinnings. Their coexistence in the same patient, although uncommon, is documented in the literature. Further, several cases of vitiligo induced by biological drugs in psoriatic patients are repo...

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Veröffentlicht in:Case Reports in Dermatology 2021-07, Vol.13 (2), p.372-378
Hauptverfasser: Burlando, Martina, Muracchioli, Andrea, Cozzani, Emanuele, Parodi, Aurora
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container_title Case Reports in Dermatology
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creator Burlando, Martina
Muracchioli, Andrea
Cozzani, Emanuele
Parodi, Aurora
description Psoriasis and vitiligo are 2 multifactorial immune-mediated diseases, partially sharing pathogenetic underpinnings. Their coexistence in the same patient, although uncommon, is documented in the literature. Further, several cases of vitiligo induced by biological drugs in psoriatic patients are reported. However, improvements in psoriasis and pre-existing vitiligo after the introduction of biological therapy are also described. To date, anti-TNF-alpha is the most cited group of biological drugs that induce new-onset vitiligo or progression of pre-existence vitiligo in psoriatic patients. Even anti-IL-12/23 class would seem to induce vitiligo (as in our case) or even worse it. Anti-IL-17 drugs induce a progression of pre-existing vitiligo while, to date, no cases are reported in literature considering anti-IL-23 class.
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source DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Karger Open Access
subjects biologic therapy
Biological products
Case and Review
Case reports
Cytokines
Development and progression
Disease
Drugs
Immunotherapy
Monoclonal antibodies
narrative review
Patients
Penis
Psoriasis
TNF inhibitors
Tumor necrosis factor
Vitiligo
title Psoriasis, Vitiligo, and Biologic Therapy: Case Report and Narrative Review
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