Synthesis, preclinical evaluation, and a pilot clinical imaging study of [18F]AlF-NOTA-JR11 for neuroendocrine neoplasms compared with [68Ga]Ga-DOTA-TATE

Purpose A [ 18 F]AlF-labeled somatostatin receptor (SSTR) antagonist was developed for imaging of neuroendocrine neoplasms (NENs), evaluated and compared with [ 68 Ga]Ga-DOTA-TATE. Method [ 18 F]AlF-NOTA-JR11 was synthesized manually and qualified with high-performance liquid chromatography (HPLC) a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of nuclear medicine and molecular imaging 2021-09, Vol.48 (10), p.3129-3140
Hauptverfasser:	Xie, Qing, Liu, Teli, Ding, Jing, Zhou, Nina, Meng, Xiangxi, Zhu, Hua, Li, Nan, Yu, Jiangyuan, Yang, Zhi
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Biodistribution Cardiology Chromatography Computed tomography Digestive system Fluorine isotopes High performance liquid chromatography Imaging Internalization Lesions Magnetic resonance imaging Mass spectrometry Mass spectroscopy Medical imaging Medicine Medicine & Public Health Neoplasms Neuroendocrine tumors Nuclear Medicine Oncology Organs Original Article Orthopedics Patients Positron emission Positron emission tomography Radiochemistry Radiology Radiopharmacy Somatostatin Somatostatin receptors Stereoisomerism Stereoisomers Tomography Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!