Evaluation of lactose based 3D powder bed printed pharmaceutical drug product tablets

It is key to understand powder blend characteristics in relation to tablet characteristics when using pharmaceutical 3D printing, in order to obtain 3D powder bed printed tablets that comply with the pharmaceutical specifications. There is limited literature available on excipient selection for 3D p...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Powder technology 2021-09, Vol.390, p.97-102
Hauptverfasser: van den Heuvel, Korinde A., de Wit, Myrthe T.W., Dickhoff, Bastiaan H.J.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 102
container_issue
container_start_page 97
container_title Powder technology
container_volume 390
creator van den Heuvel, Korinde A.
de Wit, Myrthe T.W.
Dickhoff, Bastiaan H.J.
description It is key to understand powder blend characteristics in relation to tablet characteristics when using pharmaceutical 3D printing, in order to obtain 3D powder bed printed tablets that comply with the pharmaceutical specifications. There is limited literature available on excipient selection for 3D printing, even though the only marketed 3D printed drug is prepared with powder bed printing. In this study, the impact of different particle size distributions of lactose-starch base formulations on key critical material attributes such as wettability, consolidation and flowability was studied. It was found that fewer fines in the particle size of the blend is beneficial for a fast penetration time of the ink (liquid) into the powder bed. The impact of varying the print settings or binder type on primary tablet properties such as hardness and dissolution was studied using formulations with Acetaminophen or Diclofenac Sodium. It was found that optimizing the base formulation and print settings have to be in conjunction as they are closely related. This study shows in detail how hydrophilic/hydrophobic API's can be successfully formulated into 3D printed tablets taking into account the formulation considerations as described. [Display omitted] •A lactose monohydrate binder blend is preferred for 3D powder bed printing.•Wettability is related to the particle size distribution of the blend.•A hydrophilic and hydrophobic API was successfully formulated into a printed tablet.•The impact of pre-blend/print settings on tablet hardness and dissolution was studied.•Optimizing the pre-blend and print settings have to be in conjunction for 3D printing.
doi_str_mv 10.1016/j.powtec.2021.05.050
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2569690784</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0032591021004575</els_id><sourcerecordid>2569690784</sourcerecordid><originalsourceid>FETCH-LOGICAL-c380t-cf57df92879bb505542f0341a550bfa7b395d61fb854a3fd48b60cb33db349a53</originalsourceid><addsrcrecordid>eNp9UE1LxDAUDKLguvoPPAQ8t740TT8ugqzrByx4ccFbyKe2dJs1SVf892apZ2Hg8XhvZphB6JpAToBUt32-d9_RqLyAguTAEuAELUhT04wWzfspWgDQImMtgXN0EUIPABUlsEDb9UEMk4idG7GzeBAqumCwFMFoTB9wEtbGY5m2ve_GeJyfwu-EMlPslBiw9tNHujk9qYijkIOJ4RKdWTEEc_U3l2j7uH5bPWeb16eX1f0mU7SBmCnLam3boqlbKRkwVhYWaEkEYyCtqCVtma6IlQ0rBbW6bGQFSlKqJS1bwegS3cy6yf9rMiHy3k1-TJa8YFVbtVA3Zfoq5y_lXQjeWJ6i7IT_4QT4sUDe87lAfiyQA0uARLubaSYlOHTG86A6MyqjO29U5Np1_wv8AvqBe74</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2569690784</pqid></control><display><type>article</type><title>Evaluation of lactose based 3D powder bed printed pharmaceutical drug product tablets</title><source>Elsevier ScienceDirect Journals Complete</source><creator>van den Heuvel, Korinde A. ; de Wit, Myrthe T.W. ; Dickhoff, Bastiaan H.J.</creator><creatorcontrib>van den Heuvel, Korinde A. ; de Wit, Myrthe T.W. ; Dickhoff, Bastiaan H.J.</creatorcontrib><description>It is key to understand powder blend characteristics in relation to tablet characteristics when using pharmaceutical 3D printing, in order to obtain 3D powder bed printed tablets that comply with the pharmaceutical specifications. There is limited literature available on excipient selection for 3D printing, even though the only marketed 3D printed drug is prepared with powder bed printing. In this study, the impact of different particle size distributions of lactose-starch base formulations on key critical material attributes such as wettability, consolidation and flowability was studied. It was found that fewer fines in the particle size of the blend is beneficial for a fast penetration time of the ink (liquid) into the powder bed. The impact of varying the print settings or binder type on primary tablet properties such as hardness and dissolution was studied using formulations with Acetaminophen or Diclofenac Sodium. It was found that optimizing the base formulation and print settings have to be in conjunction as they are closely related. This study shows in detail how hydrophilic/hydrophobic API's can be successfully formulated into 3D printed tablets taking into account the formulation considerations as described. [Display omitted] •A lactose monohydrate binder blend is preferred for 3D powder bed printing.•Wettability is related to the particle size distribution of the blend.•A hydrophilic and hydrophobic API was successfully formulated into a printed tablet.•The impact of pre-blend/print settings on tablet hardness and dissolution was studied.•Optimizing the pre-blend and print settings have to be in conjunction for 3D printing.</description><identifier>ISSN: 0032-5910</identifier><identifier>EISSN: 1873-328X</identifier><identifier>DOI: 10.1016/j.powtec.2021.05.050</identifier><language>eng</language><publisher>Lausanne: Elsevier B.V</publisher><subject>3-D printers ; 3D printing ; Acetaminophen ; Additive manufacturing ; Diclofenac ; Drug delivery ; Excipients ; Fines ; Formulations ; Hydrophobicity ; Lactose ; Particle size ; Pharmaceuticals ; Powder ; Powder bed printing ; Powder beds ; Printing ; Starch ; Tablets ; Three dimensional printing ; Wettability</subject><ispartof>Powder technology, 2021-09, Vol.390, p.97-102</ispartof><rights>2021 The Authors</rights><rights>Copyright Elsevier BV Sep 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-cf57df92879bb505542f0341a550bfa7b395d61fb854a3fd48b60cb33db349a53</citedby><cites>FETCH-LOGICAL-c380t-cf57df92879bb505542f0341a550bfa7b395d61fb854a3fd48b60cb33db349a53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.powtec.2021.05.050$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>van den Heuvel, Korinde A.</creatorcontrib><creatorcontrib>de Wit, Myrthe T.W.</creatorcontrib><creatorcontrib>Dickhoff, Bastiaan H.J.</creatorcontrib><title>Evaluation of lactose based 3D powder bed printed pharmaceutical drug product tablets</title><title>Powder technology</title><description>It is key to understand powder blend characteristics in relation to tablet characteristics when using pharmaceutical 3D printing, in order to obtain 3D powder bed printed tablets that comply with the pharmaceutical specifications. There is limited literature available on excipient selection for 3D printing, even though the only marketed 3D printed drug is prepared with powder bed printing. In this study, the impact of different particle size distributions of lactose-starch base formulations on key critical material attributes such as wettability, consolidation and flowability was studied. It was found that fewer fines in the particle size of the blend is beneficial for a fast penetration time of the ink (liquid) into the powder bed. The impact of varying the print settings or binder type on primary tablet properties such as hardness and dissolution was studied using formulations with Acetaminophen or Diclofenac Sodium. It was found that optimizing the base formulation and print settings have to be in conjunction as they are closely related. This study shows in detail how hydrophilic/hydrophobic API's can be successfully formulated into 3D printed tablets taking into account the formulation considerations as described. [Display omitted] •A lactose monohydrate binder blend is preferred for 3D powder bed printing.•Wettability is related to the particle size distribution of the blend.•A hydrophilic and hydrophobic API was successfully formulated into a printed tablet.•The impact of pre-blend/print settings on tablet hardness and dissolution was studied.•Optimizing the pre-blend and print settings have to be in conjunction for 3D printing.</description><subject>3-D printers</subject><subject>3D printing</subject><subject>Acetaminophen</subject><subject>Additive manufacturing</subject><subject>Diclofenac</subject><subject>Drug delivery</subject><subject>Excipients</subject><subject>Fines</subject><subject>Formulations</subject><subject>Hydrophobicity</subject><subject>Lactose</subject><subject>Particle size</subject><subject>Pharmaceuticals</subject><subject>Powder</subject><subject>Powder bed printing</subject><subject>Powder beds</subject><subject>Printing</subject><subject>Starch</subject><subject>Tablets</subject><subject>Three dimensional printing</subject><subject>Wettability</subject><issn>0032-5910</issn><issn>1873-328X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9UE1LxDAUDKLguvoPPAQ8t740TT8ugqzrByx4ccFbyKe2dJs1SVf892apZ2Hg8XhvZphB6JpAToBUt32-d9_RqLyAguTAEuAELUhT04wWzfspWgDQImMtgXN0EUIPABUlsEDb9UEMk4idG7GzeBAqumCwFMFoTB9wEtbGY5m2ve_GeJyfwu-EMlPslBiw9tNHujk9qYijkIOJ4RKdWTEEc_U3l2j7uH5bPWeb16eX1f0mU7SBmCnLam3boqlbKRkwVhYWaEkEYyCtqCVtma6IlQ0rBbW6bGQFSlKqJS1bwegS3cy6yf9rMiHy3k1-TJa8YFVbtVA3Zfoq5y_lXQjeWJ6i7IT_4QT4sUDe87lAfiyQA0uARLubaSYlOHTG86A6MyqjO29U5Np1_wv8AvqBe74</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>van den Heuvel, Korinde A.</creator><creator>de Wit, Myrthe T.W.</creator><creator>Dickhoff, Bastiaan H.J.</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>6I.</scope><scope>AAFTH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7ST</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>JG9</scope><scope>SOI</scope></search><sort><creationdate>202109</creationdate><title>Evaluation of lactose based 3D powder bed printed pharmaceutical drug product tablets</title><author>van den Heuvel, Korinde A. ; de Wit, Myrthe T.W. ; Dickhoff, Bastiaan H.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-cf57df92879bb505542f0341a550bfa7b395d61fb854a3fd48b60cb33db349a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>3-D printers</topic><topic>3D printing</topic><topic>Acetaminophen</topic><topic>Additive manufacturing</topic><topic>Diclofenac</topic><topic>Drug delivery</topic><topic>Excipients</topic><topic>Fines</topic><topic>Formulations</topic><topic>Hydrophobicity</topic><topic>Lactose</topic><topic>Particle size</topic><topic>Pharmaceuticals</topic><topic>Powder</topic><topic>Powder bed printing</topic><topic>Powder beds</topic><topic>Printing</topic><topic>Starch</topic><topic>Tablets</topic><topic>Three dimensional printing</topic><topic>Wettability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van den Heuvel, Korinde A.</creatorcontrib><creatorcontrib>de Wit, Myrthe T.W.</creatorcontrib><creatorcontrib>Dickhoff, Bastiaan H.J.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Environment Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Materials Research Database</collection><collection>Environment Abstracts</collection><jtitle>Powder technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van den Heuvel, Korinde A.</au><au>de Wit, Myrthe T.W.</au><au>Dickhoff, Bastiaan H.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of lactose based 3D powder bed printed pharmaceutical drug product tablets</atitle><jtitle>Powder technology</jtitle><date>2021-09</date><risdate>2021</risdate><volume>390</volume><spage>97</spage><epage>102</epage><pages>97-102</pages><issn>0032-5910</issn><eissn>1873-328X</eissn><abstract>It is key to understand powder blend characteristics in relation to tablet characteristics when using pharmaceutical 3D printing, in order to obtain 3D powder bed printed tablets that comply with the pharmaceutical specifications. There is limited literature available on excipient selection for 3D printing, even though the only marketed 3D printed drug is prepared with powder bed printing. In this study, the impact of different particle size distributions of lactose-starch base formulations on key critical material attributes such as wettability, consolidation and flowability was studied. It was found that fewer fines in the particle size of the blend is beneficial for a fast penetration time of the ink (liquid) into the powder bed. The impact of varying the print settings or binder type on primary tablet properties such as hardness and dissolution was studied using formulations with Acetaminophen or Diclofenac Sodium. It was found that optimizing the base formulation and print settings have to be in conjunction as they are closely related. This study shows in detail how hydrophilic/hydrophobic API's can be successfully formulated into 3D printed tablets taking into account the formulation considerations as described. [Display omitted] •A lactose monohydrate binder blend is preferred for 3D powder bed printing.•Wettability is related to the particle size distribution of the blend.•A hydrophilic and hydrophobic API was successfully formulated into a printed tablet.•The impact of pre-blend/print settings on tablet hardness and dissolution was studied.•Optimizing the pre-blend and print settings have to be in conjunction for 3D printing.</abstract><cop>Lausanne</cop><pub>Elsevier B.V</pub><doi>10.1016/j.powtec.2021.05.050</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0032-5910
ispartof Powder technology, 2021-09, Vol.390, p.97-102
issn 0032-5910
1873-328X
language eng
recordid cdi_proquest_journals_2569690784
source Elsevier ScienceDirect Journals Complete
subjects 3-D printers
3D printing
Acetaminophen
Additive manufacturing
Diclofenac
Drug delivery
Excipients
Fines
Formulations
Hydrophobicity
Lactose
Particle size
Pharmaceuticals
Powder
Powder bed printing
Powder beds
Printing
Starch
Tablets
Three dimensional printing
Wettability
title Evaluation of lactose based 3D powder bed printed pharmaceutical drug product tablets
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T10%3A16%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20of%20lactose%20based%203D%20powder%20bed%20printed%20pharmaceutical%20drug%20product%20tablets&rft.jtitle=Powder%20technology&rft.au=van%20den%20Heuvel,%20Korinde%20A.&rft.date=2021-09&rft.volume=390&rft.spage=97&rft.epage=102&rft.pages=97-102&rft.issn=0032-5910&rft.eissn=1873-328X&rft_id=info:doi/10.1016/j.powtec.2021.05.050&rft_dat=%3Cproquest_cross%3E2569690784%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2569690784&rft_id=info:pmid/&rft_els_id=S0032591021004575&rfr_iscdi=true