Acquisition and extinction of contextual fear conditioning in Carioca high- and low-conditioned freezing rats
Carioca High- and Low-conditioned Freezing (CHF and CLF, respectively) rats are two bidirectional breeding lines of animals with high and low levels of defensive conditioned freezing response to contextual cues that are associated with an aversive stimulus. In the last decade, various studies have i...
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| Veröffentlicht in: | Learning and motivation 2021-08, Vol.75, p.101744, Article 101744 |
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| creator | Lages, Yury V. Maisonnette, Silvia S. Rosseti, Flávia P. Landeira-Fernandez, J. |
| description | Carioca High- and Low-conditioned Freezing (CHF and CLF, respectively) rats are two bidirectional breeding lines of animals with high and low levels of defensive conditioned freezing response to contextual cues that are associated with an aversive stimulus. In the last decade, various studies have investigated their physiology and response to other external stimuli as a model of trait anxiety. However, the process of the extinction of their characteristic freezing response is not well understood. The present study investigated the acquisition and extinction of a contextual fear conditioning protocol among these animals. The results showed that CLF rats were unable to consolidate aversive memories and thus were unresponsive to extinction. In contrast, CHF rats still exhibited a large freezing response to contextual cues and were susceptible to extinction, reaching levels of freezing that were comparable to control, randomly bred animals. These findings contribute to validating CHF rats as a model of trait anxiety and their usefulness for evaluating exposure protocols to ameliorate excessive levels of context-conditioned fear. |
| doi_str_mv | 10.1016/j.lmot.2021.101744 |
| format | Article |
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In the last decade, various studies have investigated their physiology and response to other external stimuli as a model of trait anxiety. However, the process of the extinction of their characteristic freezing response is not well understood. The present study investigated the acquisition and extinction of a contextual fear conditioning protocol among these animals. The results showed that CLF rats were unable to consolidate aversive memories and thus were unresponsive to extinction. In contrast, CHF rats still exhibited a large freezing response to contextual cues and were susceptible to extinction, reaching levels of freezing that were comparable to control, randomly bred animals. 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These findings contribute to validating CHF rats as a model of trait anxiety and their usefulness for evaluating exposure protocols to ameliorate excessive levels of context-conditioned fear.</description><subject>Anxiety</subject><subject>Breeding lines</subject><subject>Contextual fear conditioning</subject><subject>Defensive behavior</subject><subject>External stimuli</subject><subject>Extinction</subject><subject>Extinction behavior</subject><subject>Fear</subject><subject>Fear conditioning</subject><subject>Tonic immobility</subject><issn>0023-9690</issn><issn>1095-9122</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kEtPwzAQhC0EEqXwBzhZ4pzideIklrhUFS8JiQucLePYraPUbm2H168naRBHTqsZfbO7GoQugSyAQHndLrqtTwtKKIxGVRRHaAaEs4wDpcdoRgjNM15ycorOYmwJAWA1n6HtUu17G22y3mHpGqw_k3XqIL3Byrs0OL3ssNEyjLo5sNatsXV4JYP1SuKNXW-yQ77zH9kfpRtsgtbfIx1kiufoxMgu6ovfOUevd7cvq4fs6fn-cbV8yhRldcoaraoyJ8BUqaRhVUFNUbOCSV2V3FDIASqpZAUSJK0VgCneaDNapqYFpfkcXU17d8Hvex2TaH0f3HBSUFbysq4rzgaKTpQKPsagjdgFu5XhSwARY62iFWOtYqxVTLUOoZsppIf_360OIiqrndKNDVol0Xj7X_wHz2KCMA</recordid><startdate>202108</startdate><enddate>202108</enddate><creator>Lages, Yury V.</creator><creator>Maisonnette, Silvia S.</creator><creator>Rosseti, Flávia P.</creator><creator>Landeira-Fernandez, J.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0003-4100-4510</orcidid><orcidid>https://orcid.org/0000-0002-8395-8008</orcidid></search><sort><creationdate>202108</creationdate><title>Acquisition and extinction of contextual fear conditioning in Carioca high- and low-conditioned freezing rats</title><author>Lages, Yury V. ; Maisonnette, Silvia S. ; Rosseti, Flávia P. ; Landeira-Fernandez, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c258t-dec763015c6caf5742f48545ae769f213117aca71a1a28c11f4b2d7acaf824223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Anxiety</topic><topic>Breeding lines</topic><topic>Contextual fear conditioning</topic><topic>Defensive behavior</topic><topic>External stimuli</topic><topic>Extinction</topic><topic>Extinction behavior</topic><topic>Fear</topic><topic>Fear conditioning</topic><topic>Tonic immobility</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lages, Yury V.</creatorcontrib><creatorcontrib>Maisonnette, Silvia S.</creatorcontrib><creatorcontrib>Rosseti, Flávia P.</creatorcontrib><creatorcontrib>Landeira-Fernandez, J.</creatorcontrib><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Learning and motivation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lages, Yury V.</au><au>Maisonnette, Silvia S.</au><au>Rosseti, Flávia P.</au><au>Landeira-Fernandez, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acquisition and extinction of contextual fear conditioning in Carioca high- and low-conditioned freezing rats</atitle><jtitle>Learning and motivation</jtitle><date>2021-08</date><risdate>2021</risdate><volume>75</volume><spage>101744</spage><pages>101744-</pages><artnum>101744</artnum><issn>0023-9690</issn><eissn>1095-9122</eissn><abstract>Carioca High- and Low-conditioned Freezing (CHF and CLF, respectively) rats are two bidirectional breeding lines of animals with high and low levels of defensive conditioned freezing response to contextual cues that are associated with an aversive stimulus. 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| ispartof | Learning and motivation, 2021-08, Vol.75, p.101744, Article 101744 |
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| subjects | Anxiety Breeding lines Contextual fear conditioning Defensive behavior External stimuli Extinction Extinction behavior Fear Fear conditioning Tonic immobility |
| title | Acquisition and extinction of contextual fear conditioning in Carioca high- and low-conditioned freezing rats |
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