Targeting diacylglycerol lipase reduces alcohol consumption in preclinical models

Alcohol use disorder (AUD) is associated with substantial morbidity, mortality, and societal cost, and pharmacological treatment options are limited. The endogenous cannabinoid (eCB) signaling system is critically involved in reward processing, and alcohol intake is positively correlated with releas...

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Veröffentlicht in:	The Journal of clinical investigation 2021-09, Vol.131 (17), p.1-14
Hauptverfasser:	Winters, Nathan D, Bedse, Gaurav, Astafyev, Anastasia A, Patrick, Toni A, Altemus, Megan, Morgan, Amanda J, Mukerjee, Snigdha, Johnson, Keenan D, Mahajan, Vikrant R, Uddin, Md Jashim, Kingsley, Philip J, Centanni, Samuel W, Siciliano, Cody A, Samuels, David C, Marnett, Lawrence J, Winder, Danny G, Patel, Sachin
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Arachidonoylglycerol Alcohol use Animal models Aversion Behavior Biomedical research Brain Cannabinoids Chronic illnesses Diglycerides Dopamine Drinking behavior Drug therapy Enzymes Ethanol Females Lipase Lipoprotein lipase Males Mesencephalon Morbidity Reinforcement γ-Aminobutyric acid
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