Whole brain volume and cortical thickness abnormalities in Wilson’s disease: a clinical correlation study
Wilson’s disease (WD) is an inherited autosomal recessive disorder of copper metabolism, and its neurological and neuropsychiatric manifestations are associated with copper accumulation in brain. A few neuroimaging studies have shown that gray matter atrophy in WD affects both subcortical structures...
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| creator | Song, Yukun Zou, Lin Zhao, Jing Zhou, Xiangxue Huang, Yingqian Qiu, Haishan Han, Haiwei Yang, Zhiyun Li, Xunhua Tang, Xiaoying Chu, Jianping |
| description | Wilson’s disease (WD) is an inherited autosomal recessive disorder of copper metabolism, and its neurological and neuropsychiatric manifestations are associated with copper accumulation in brain. A few neuroimaging studies have shown that gray matter atrophy in WD affects both subcortical structures and cortex. This study aims to quantitatively evaluate the morphometric brain abnormalities in patients with WD in terms of whole brain volume and cortical thickness and their associations with clinical severity of WD. Thirty patients clinically diagnosed as WD with neurological manifestations and 25 healthy controls (HC) were recruited. 3D T1-weighted images were segmented into 276 whole-brain regions of interest (ROIs) and 68 cortical ROIs. WD-vs-HC group comparisons were then conducted for each ROI. The associations between those morphometric measurements and the Global Assessment Scale (GAS) score for WD were analyzed. Compared with HC, significant WD-related volumetric decreases were found in the bilateral subcortical nuclei (putamen, globus pallidus, caudate nucleus, substantia nigra, red nucleus and thalamus), diffuse white matter and several gray matter regions. WD patients showed reduced cortical thickness in the left precentral gyrus and the left insula. Further, the volumes of the right globus pallidus, bilateral putamen, right external capsule and left superior longitudinal fasciculus were negatively correlated with GAS. Our results indicated that significant WD-related morphometric abnormalities were quantified in terms of whole-brain volumes and cortical thicknesses, some of which correlated significantly to the clinical severity of WD. Those morphometrics may provide a potentially effective biomarker of WD. |
| doi_str_mv | 10.1007/s11682-020-00373-9 |
| format | Article |
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A few neuroimaging studies have shown that gray matter atrophy in WD affects both subcortical structures and cortex. This study aims to quantitatively evaluate the morphometric brain abnormalities in patients with WD in terms of whole brain volume and cortical thickness and their associations with clinical severity of WD. Thirty patients clinically diagnosed as WD with neurological manifestations and 25 healthy controls (HC) were recruited. 3D T1-weighted images were segmented into 276 whole-brain regions of interest (ROIs) and 68 cortical ROIs. WD-vs-HC group comparisons were then conducted for each ROI. The associations between those morphometric measurements and the Global Assessment Scale (GAS) score for WD were analyzed. Compared with HC, significant WD-related volumetric decreases were found in the bilateral subcortical nuclei (putamen, globus pallidus, caudate nucleus, substantia nigra, red nucleus and thalamus), diffuse white matter and several gray matter regions. WD patients showed reduced cortical thickness in the left precentral gyrus and the left insula. Further, the volumes of the right globus pallidus, bilateral putamen, right external capsule and left superior longitudinal fasciculus were negatively correlated with GAS. Our results indicated that significant WD-related morphometric abnormalities were quantified in terms of whole-brain volumes and cortical thicknesses, some of which correlated significantly to the clinical severity of WD. Those morphometrics may provide a potentially effective biomarker of WD.</description><identifier>ISSN: 1931-7557</identifier><identifier>EISSN: 1931-7565</identifier><identifier>DOI: 10.1007/s11682-020-00373-9</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Abnormalities ; Age ; Alzheimer's disease ; Atrophy ; Biomarkers ; Biomedical and Life Sciences ; Biomedicine ; Brain ; Brain research ; Caudate nucleus ; Copper ; Globus pallidus ; Hereditary diseases ; Hospitals ; Medical imaging ; Mental disorders ; Metabolism ; Morphometry ; Neuroimaging ; Neuropsychology ; Neuroradiology ; Neurosciences ; Original Research ; Parameter estimation ; Patients ; Precentral gyrus ; Psychiatry ; Putamen ; Red nucleus ; Registration ; Substantia alba ; Substantia grisea ; Substantia nigra ; Thalamus ; Thickness ; Volumetric analysis ; Wilson's disease</subject><ispartof>Brain imaging and behavior, 2021-08, Vol.15 (4), p.1778-1787</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-11201199be2cf733b8e412200f7275a23ee5d7cf4948a9d355feecd3432b02b13</citedby><cites>FETCH-LOGICAL-c352t-11201199be2cf733b8e412200f7275a23ee5d7cf4948a9d355feecd3432b02b13</cites><orcidid>0000-0001-5483-2169</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11682-020-00373-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11682-020-00373-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids></links><search><creatorcontrib>Song, Yukun</creatorcontrib><creatorcontrib>Zou, Lin</creatorcontrib><creatorcontrib>Zhao, Jing</creatorcontrib><creatorcontrib>Zhou, Xiangxue</creatorcontrib><creatorcontrib>Huang, Yingqian</creatorcontrib><creatorcontrib>Qiu, Haishan</creatorcontrib><creatorcontrib>Han, Haiwei</creatorcontrib><creatorcontrib>Yang, Zhiyun</creatorcontrib><creatorcontrib>Li, Xunhua</creatorcontrib><creatorcontrib>Tang, Xiaoying</creatorcontrib><creatorcontrib>Chu, Jianping</creatorcontrib><title>Whole brain volume and cortical thickness abnormalities in Wilson’s disease: a clinical correlation study</title><title>Brain imaging and behavior</title><addtitle>Brain Imaging and Behavior</addtitle><description>Wilson’s disease (WD) is an inherited autosomal recessive disorder of copper metabolism, and its neurological and neuropsychiatric manifestations are associated with copper accumulation in brain. A few neuroimaging studies have shown that gray matter atrophy in WD affects both subcortical structures and cortex. This study aims to quantitatively evaluate the morphometric brain abnormalities in patients with WD in terms of whole brain volume and cortical thickness and their associations with clinical severity of WD. Thirty patients clinically diagnosed as WD with neurological manifestations and 25 healthy controls (HC) were recruited. 3D T1-weighted images were segmented into 276 whole-brain regions of interest (ROIs) and 68 cortical ROIs. WD-vs-HC group comparisons were then conducted for each ROI. The associations between those morphometric measurements and the Global Assessment Scale (GAS) score for WD were analyzed. Compared with HC, significant WD-related volumetric decreases were found in the bilateral subcortical nuclei (putamen, globus pallidus, caudate nucleus, substantia nigra, red nucleus and thalamus), diffuse white matter and several gray matter regions. WD patients showed reduced cortical thickness in the left precentral gyrus and the left insula. Further, the volumes of the right globus pallidus, bilateral putamen, right external capsule and left superior longitudinal fasciculus were negatively correlated with GAS. Our results indicated that significant WD-related morphometric abnormalities were quantified in terms of whole-brain volumes and cortical thicknesses, some of which correlated significantly to the clinical severity of WD. Those morphometrics may provide a potentially effective biomarker of WD.</description><subject>Abnormalities</subject><subject>Age</subject><subject>Alzheimer's disease</subject><subject>Atrophy</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain</subject><subject>Brain research</subject><subject>Caudate nucleus</subject><subject>Copper</subject><subject>Globus pallidus</subject><subject>Hereditary diseases</subject><subject>Hospitals</subject><subject>Medical imaging</subject><subject>Mental disorders</subject><subject>Metabolism</subject><subject>Morphometry</subject><subject>Neuroimaging</subject><subject>Neuropsychology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Original Research</subject><subject>Parameter estimation</subject><subject>Patients</subject><subject>Precentral gyrus</subject><subject>Psychiatry</subject><subject>Putamen</subject><subject>Red nucleus</subject><subject>Registration</subject><subject>Substantia alba</subject><subject>Substantia grisea</subject><subject>Substantia nigra</subject><subject>Thalamus</subject><subject>Thickness</subject><subject>Volumetric analysis</subject><subject>Wilson's 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brain volume and cortical thickness abnormalities in Wilson’s disease: a clinical correlation study</title><author>Song, Yukun ; Zou, Lin ; Zhao, Jing ; Zhou, Xiangxue ; Huang, Yingqian ; Qiu, Haishan ; Han, Haiwei ; Yang, Zhiyun ; Li, Xunhua ; Tang, Xiaoying ; Chu, Jianping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-11201199be2cf733b8e412200f7275a23ee5d7cf4948a9d355feecd3432b02b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Abnormalities</topic><topic>Age</topic><topic>Alzheimer's disease</topic><topic>Atrophy</topic><topic>Biomarkers</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain</topic><topic>Brain research</topic><topic>Caudate nucleus</topic><topic>Copper</topic><topic>Globus pallidus</topic><topic>Hereditary diseases</topic><topic>Hospitals</topic><topic>Medical imaging</topic><topic>Mental 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Yingqian</au><au>Qiu, Haishan</au><au>Han, Haiwei</au><au>Yang, Zhiyun</au><au>Li, Xunhua</au><au>Tang, Xiaoying</au><au>Chu, Jianping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Whole brain volume and cortical thickness abnormalities in Wilson’s disease: a clinical correlation study</atitle><jtitle>Brain imaging and behavior</jtitle><stitle>Brain Imaging and Behavior</stitle><date>2021-08-01</date><risdate>2021</risdate><volume>15</volume><issue>4</issue><spage>1778</spage><epage>1787</epage><pages>1778-1787</pages><issn>1931-7557</issn><eissn>1931-7565</eissn><abstract>Wilson’s disease (WD) is an inherited autosomal recessive disorder of copper metabolism, and its neurological and neuropsychiatric manifestations are associated with copper accumulation in brain. A few neuroimaging studies have shown that gray matter atrophy in WD affects both subcortical structures and cortex. This study aims to quantitatively evaluate the morphometric brain abnormalities in patients with WD in terms of whole brain volume and cortical thickness and their associations with clinical severity of WD. Thirty patients clinically diagnosed as WD with neurological manifestations and 25 healthy controls (HC) were recruited. 3D T1-weighted images were segmented into 276 whole-brain regions of interest (ROIs) and 68 cortical ROIs. WD-vs-HC group comparisons were then conducted for each ROI. The associations between those morphometric measurements and the Global Assessment Scale (GAS) score for WD were analyzed. Compared with HC, significant WD-related volumetric decreases were found in the bilateral subcortical nuclei (putamen, globus pallidus, caudate nucleus, substantia nigra, red nucleus and thalamus), diffuse white matter and several gray matter regions. WD patients showed reduced cortical thickness in the left precentral gyrus and the left insula. Further, the volumes of the right globus pallidus, bilateral putamen, right external capsule and left superior longitudinal fasciculus were negatively correlated with GAS. Our results indicated that significant WD-related morphometric abnormalities were quantified in terms of whole-brain volumes and cortical thicknesses, some of which correlated significantly to the clinical severity of WD. Those morphometrics may provide a potentially effective biomarker of WD.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s11682-020-00373-9</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-5483-2169</orcidid></addata></record> |
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| subjects | Abnormalities Age Alzheimer's disease Atrophy Biomarkers Biomedical and Life Sciences Biomedicine Brain Brain research Caudate nucleus Copper Globus pallidus Hereditary diseases Hospitals Medical imaging Mental disorders Metabolism Morphometry Neuroimaging Neuropsychology Neuroradiology Neurosciences Original Research Parameter estimation Patients Precentral gyrus Psychiatry Putamen Red nucleus Registration Substantia alba Substantia grisea Substantia nigra Thalamus Thickness Volumetric analysis Wilson's disease |
| title | Whole brain volume and cortical thickness abnormalities in Wilson’s disease: a clinical correlation study |
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