Particulate matter exposure exacerbates susceptibility to SARS-CoV-2 infection in humanized ACE2 mice
The global outbreak of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as of 8 May 2021, has surpassed 150 700 000 infections and 3 279 000 deaths worldwide. Evidence indicates that SARS-CoV-2 RNA can be detected on particulate ma...
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| Veröffentlicht in: | Dōngwùxué yánjiū 2021-05, Vol.42 (3), p.335-338 |
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| creator | Zhu, Teng-Yu Qiu, Huan Cao, Qi-Qi Duan, Zi-Lei Liu, Feng-Liang Song, Tian-Zhang Liu, Yang Fang, Ya-Qun Wu, Guang-Ming Zheng, Yong-Tang Ding, Wen-Jun Lai, Ren Jin, Lin |
| description | The global outbreak of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as of 8 May 2021, has surpassed 150 700 000 infections and 3 279 000 deaths worldwide. Evidence indicates that SARS-CoV-2 RNA can be detected on particulate matter (PM), and COVID-19 cases are correlated with levels of air pollutants. However, the mechanisms of PM involvement in the spread of SARS-CoV-2 remain poorly understood. Here, we found that PM exposure increased the expression level of angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) in several epithelial cells and increased the adsorption of the SARS-CoV-2 spike protein. Instillation of PM in a hACE2 mouse model significantly increased the expression of
and
and viral replication in the lungs. Furthermore, PM exacerbated the pulmonary lesions caused by SARS-CoV-2 infection in the hACE2 mice. In conclusion, our study demonstrated that PM is an epidemiological factor of COVID-19, emphasizing the necessity of wearing anti-PM masks to cope with this global pandemic. |
| doi_str_mv | 10.24272/j.issn.2095-8137.2021.088 |
| format | Article |
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and
and viral replication in the lungs. Furthermore, PM exacerbated the pulmonary lesions caused by SARS-CoV-2 infection in the hACE2 mice. In conclusion, our study demonstrated that PM is an epidemiological factor of COVID-19, emphasizing the necessity of wearing anti-PM masks to cope with this global pandemic.</description><identifier>ISSN: 2095-8137</identifier><identifier>ISSN: 0254-5853</identifier><identifier>DOI: 10.24272/j.issn.2095-8137.2021.088</identifier><identifier>PMID: 33998180</identifier><language>eng</language><publisher>China: Kunming Institute of Zoology, The Chinese Academy of Sciences</publisher><subject>ACE2 ; Adsorption - drug effects ; Angiotensin-converting enzyme 2 ; Angiotensin-Converting Enzyme 2 - metabolism ; Animals ; Coronaviruses ; COVID-19 ; COVID-19 - chemically induced ; COVID-19 - immunology ; Disease Susceptibility - chemically induced ; Disease Susceptibility - immunology ; Enzymes ; Epidemiology ; Epithelial Cells - metabolism ; Experiments ; Immunoblotting ; Infections ; Laboratories ; Letter to the Editor ; Lungs ; Masks ; Mice ; Mice, Inbred Strains ; Pandemics ; Particulate emissions ; Particulate matter ; Particulate Matter - adverse effects ; Particulate Matter - chemistry ; Pathogenesis ; Pollutants ; Proteins ; RNA, Viral - analysis ; SARS-CoV-2 - genetics ; Science ; Serine Endopeptidases - metabolism ; Severe acute respiratory syndrome coronavirus 2 ; Spike Glycoprotein, Coronavirus - metabolism ; Suspended particulate matter ; Viral diseases ; Virus Internalization - drug effects ; Zoology</subject><ispartof>Dōngwùxué yánjiū, 2021-05, Vol.42 (3), p.335-338</ispartof><rights>Copyright Kunming Institute of Zoology, The Chinese Academy of Sciences May 2021</rights><rights>Editorial Office of Zoological Research, Kunming Institute of Zoology, Chinese Academy of Sciences 2021 Editorial Office of Zoological Research, Kunming Institute of Zoology, Chinese Academy of Sciences</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-d4383cf0c1a3a5400982c784f823ec6531b006722407c0656ab4988792a93b3e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33998180$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhu, Teng-Yu</creatorcontrib><creatorcontrib>Qiu, Huan</creatorcontrib><creatorcontrib>Cao, Qi-Qi</creatorcontrib><creatorcontrib>Duan, Zi-Lei</creatorcontrib><creatorcontrib>Liu, Feng-Liang</creatorcontrib><creatorcontrib>Song, Tian-Zhang</creatorcontrib><creatorcontrib>Liu, Yang</creatorcontrib><creatorcontrib>Fang, Ya-Qun</creatorcontrib><creatorcontrib>Wu, Guang-Ming</creatorcontrib><creatorcontrib>Zheng, Yong-Tang</creatorcontrib><creatorcontrib>Ding, Wen-Jun</creatorcontrib><creatorcontrib>Lai, Ren</creatorcontrib><creatorcontrib>Jin, Lin</creatorcontrib><creatorcontrib>Centre for Cell Lineage and Atlas, Bioland Laboratory, Guangzhou, Guangdong 510530, China</creatorcontrib><creatorcontrib>中国科学院大学环境与健康实验室，北京 100049，中国</creatorcontrib><creatorcontrib>College of Life Sciences, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China</creatorcontrib><creatorcontrib>Kunming National High-level Biosafety Research Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650107, China</creatorcontrib><creatorcontrib>中国科学院昆明动物研究所中国科学院动物模型与人类疾病机理重点实验室/云南省生物活性肽重点实验室，云南 昆明 650223，中国</creatorcontrib><creatorcontrib>Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China</creatorcontrib><creatorcontrib>南京农业大学生命科学学院，江苏 南京 210095，中国</creatorcontrib><creatorcontrib>Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China</creatorcontrib><creatorcontrib>中国科学院大学昆明生命科学学院，云南 昆明 650204，中国</creatorcontrib><creatorcontrib>Laboratory of Environment and Health, University of Chinese Academy of Sciences, Beijing 100049, China</creatorcontrib><creatorcontrib>生物家园实验室细胞谱系与图谱中心，广东 广州 510530，中国</creatorcontrib><creatorcontrib>中国科学院昆明动物研究所国家昆明高等级生物安全灵长类动物实验中心，云南 昆明 650107，中国</creatorcontrib><title>Particulate matter exposure exacerbates susceptibility to SARS-CoV-2 infection in humanized ACE2 mice</title><title>Dōngwùxué yánjiū</title><addtitle>Zool Res</addtitle><description>The global outbreak of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as of 8 May 2021, has surpassed 150 700 000 infections and 3 279 000 deaths worldwide. Evidence indicates that SARS-CoV-2 RNA can be detected on particulate matter (PM), and COVID-19 cases are correlated with levels of air pollutants. However, the mechanisms of PM involvement in the spread of SARS-CoV-2 remain poorly understood. Here, we found that PM exposure increased the expression level of angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) in several epithelial cells and increased the adsorption of the SARS-CoV-2 spike protein. Instillation of PM in a hACE2 mouse model significantly increased the expression of
and
and viral replication in the lungs. Furthermore, PM exacerbated the pulmonary lesions caused by SARS-CoV-2 infection in the hACE2 mice. In conclusion, our study demonstrated that PM is an epidemiological factor of COVID-19, emphasizing the necessity of wearing anti-PM masks to cope with this global pandemic.</description><subject>ACE2</subject><subject>Adsorption - drug effects</subject><subject>Angiotensin-converting enzyme 2</subject><subject>Angiotensin-Converting Enzyme 2 - metabolism</subject><subject>Animals</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - chemically induced</subject><subject>COVID-19 - immunology</subject><subject>Disease Susceptibility - chemically induced</subject><subject>Disease Susceptibility - immunology</subject><subject>Enzymes</subject><subject>Epidemiology</subject><subject>Epithelial Cells - metabolism</subject><subject>Experiments</subject><subject>Immunoblotting</subject><subject>Infections</subject><subject>Laboratories</subject><subject>Letter to the Editor</subject><subject>Lungs</subject><subject>Masks</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Pandemics</subject><subject>Particulate emissions</subject><subject>Particulate matter</subject><subject>Particulate Matter - adverse effects</subject><subject>Particulate Matter - chemistry</subject><subject>Pathogenesis</subject><subject>Pollutants</subject><subject>Proteins</subject><subject>RNA, Viral - analysis</subject><subject>SARS-CoV-2 - genetics</subject><subject>Science</subject><subject>Serine Endopeptidases - metabolism</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Spike Glycoprotein, Coronavirus - metabolism</subject><subject>Suspended particulate matter</subject><subject>Viral diseases</subject><subject>Virus Internalization - drug 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exacerbates susceptibility to SARS-CoV-2 infection in humanized ACE2 mice</title><author>Zhu, Teng-Yu ; Qiu, Huan ; Cao, Qi-Qi ; Duan, Zi-Lei ; Liu, Feng-Liang ; Song, Tian-Zhang ; Liu, Yang ; Fang, Ya-Qun ; Wu, Guang-Ming ; Zheng, Yong-Tang ; Ding, Wen-Jun ; Lai, Ren ; Jin, Lin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-d4383cf0c1a3a5400982c784f823ec6531b006722407c0656ab4988792a93b3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>ACE2</topic><topic>Adsorption - drug effects</topic><topic>Angiotensin-converting enzyme 2</topic><topic>Angiotensin-Converting Enzyme 2 - metabolism</topic><topic>Animals</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 - chemically induced</topic><topic>COVID-19 - immunology</topic><topic>Disease Susceptibility - chemically induced</topic><topic>Disease Susceptibility - immunology</topic><topic>Enzymes</topic><topic>Epidemiology</topic><topic>Epithelial Cells - metabolism</topic><topic>Experiments</topic><topic>Immunoblotting</topic><topic>Infections</topic><topic>Laboratories</topic><topic>Letter to the Editor</topic><topic>Lungs</topic><topic>Masks</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Pandemics</topic><topic>Particulate emissions</topic><topic>Particulate matter</topic><topic>Particulate Matter - adverse effects</topic><topic>Particulate Matter - chemistry</topic><topic>Pathogenesis</topic><topic>Pollutants</topic><topic>Proteins</topic><topic>RNA, Viral - analysis</topic><topic>SARS-CoV-2 - genetics</topic><topic>Science</topic><topic>Serine Endopeptidases - metabolism</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Spike Glycoprotein, Coronavirus - metabolism</topic><topic>Suspended particulate matter</topic><topic>Viral diseases</topic><topic>Virus Internalization - drug 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& Fisheries Abstracts (ASFA) Professional</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Dōngwùxué yánjiū</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Teng-Yu</au><au>Qiu, Huan</au><au>Cao, Qi-Qi</au><au>Duan, Zi-Lei</au><au>Liu, Feng-Liang</au><au>Song, Tian-Zhang</au><au>Liu, Yang</au><au>Fang, Ya-Qun</au><au>Wu, Guang-Ming</au><au>Zheng, Yong-Tang</au><au>Ding, Wen-Jun</au><au>Lai, Ren</au><au>Jin, Lin</au><aucorp>Centre for Cell Lineage and Atlas, Bioland Laboratory, Guangzhou, Guangdong 510530, China</aucorp><aucorp>中国科学院大学环境与健康实验室，北京 100049，中国</aucorp><aucorp>College of Life Sciences, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China</aucorp><aucorp>Kunming National High-level Biosafety Research Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650107, China</aucorp><aucorp>中国科学院昆明动物研究所中国科学院动物模型与人类疾病机理重点实验室/云南省生物活性肽重点实验室，云南 昆明 650223，中国</aucorp><aucorp>Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China</aucorp><aucorp>南京农业大学生命科学学院，江苏 南京 210095，中国</aucorp><aucorp>Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China</aucorp><aucorp>中国科学院大学昆明生命科学学院，云南 昆明 650204，中国</aucorp><aucorp>Laboratory of Environment and Health, University of Chinese Academy of Sciences, Beijing 100049, China</aucorp><aucorp>生物家园实验室细胞谱系与图谱中心，广东 广州 510530，中国</aucorp><aucorp>中国科学院昆明动物研究所国家昆明高等级生物安全灵长类动物实验中心，云南 昆明 650107，中国</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Particulate matter exposure exacerbates susceptibility to SARS-CoV-2 infection in humanized ACE2 mice</atitle><jtitle>Dōngwùxué yánjiū</jtitle><addtitle>Zool Res</addtitle><date>2021-05-18</date><risdate>2021</risdate><volume>42</volume><issue>3</issue><spage>335</spage><epage>338</epage><pages>335-338</pages><issn>2095-8137</issn><issn>0254-5853</issn><abstract>The global outbreak of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as of 8 May 2021, has surpassed 150 700 000 infections and 3 279 000 deaths worldwide. Evidence indicates that SARS-CoV-2 RNA can be detected on particulate matter (PM), and COVID-19 cases are correlated with levels of air pollutants. However, the mechanisms of PM involvement in the spread of SARS-CoV-2 remain poorly understood. Here, we found that PM exposure increased the expression level of angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) in several epithelial cells and increased the adsorption of the SARS-CoV-2 spike protein. Instillation of PM in a hACE2 mouse model significantly increased the expression of
and
and viral replication in the lungs. Furthermore, PM exacerbated the pulmonary lesions caused by SARS-CoV-2 infection in the hACE2 mice. In conclusion, our study demonstrated that PM is an epidemiological factor of COVID-19, emphasizing the necessity of wearing anti-PM masks to cope with this global pandemic.</abstract><cop>China</cop><pub>Kunming Institute of Zoology, The Chinese Academy of Sciences</pub><pmid>33998180</pmid><doi>10.24272/j.issn.2095-8137.2021.088</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2095-8137 |
| ispartof | Dōngwùxué yánjiū, 2021-05, Vol.42 (3), p.335-338 |
| issn | 2095-8137 0254-5853 |
| language | eng |
| recordid | cdi_proquest_journals_2568309913 |
| source | MEDLINE; Bioline International; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | ACE2 Adsorption - drug effects Angiotensin-converting enzyme 2 Angiotensin-Converting Enzyme 2 - metabolism Animals Coronaviruses COVID-19 COVID-19 - chemically induced COVID-19 - immunology Disease Susceptibility - chemically induced Disease Susceptibility - immunology Enzymes Epidemiology Epithelial Cells - metabolism Experiments Immunoblotting Infections Laboratories Letter to the Editor Lungs Masks Mice Mice, Inbred Strains Pandemics Particulate emissions Particulate matter Particulate Matter - adverse effects Particulate Matter - chemistry Pathogenesis Pollutants Proteins RNA, Viral - analysis SARS-CoV-2 - genetics Science Serine Endopeptidases - metabolism Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - metabolism Suspended particulate matter Viral diseases Virus Internalization - drug effects Zoology |
| title | Particulate matter exposure exacerbates susceptibility to SARS-CoV-2 infection in humanized ACE2 mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T08%3A34%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Particulate%20matter%20exposure%20exacerbates%20susceptibility%20to%20SARS-CoV-2%20infection%20in%20humanized%20ACE2%20mice&rft.jtitle=D%C5%8Dngw%C3%B9xu%C3%A9%20y%C3%A1nji%C5%AB&rft.au=Zhu,%20Teng-Yu&rft.aucorp=Centre%20for%20Cell%20Lineage%20and%20Atlas,%20Bioland%20Laboratory,%20Guangzhou,%20Guangdong%20510530,%20China&rft.date=2021-05-18&rft.volume=42&rft.issue=3&rft.spage=335&rft.epage=338&rft.pages=335-338&rft.issn=2095-8137&rft_id=info:doi/10.24272/j.issn.2095-8137.2021.088&rft_dat=%3Cproquest_pubme%3E2568309913%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2568309913&rft_id=info:pmid/33998180&rfr_iscdi=true |