Dynamics of the compartmentalized Streptomyces chromosome during metabolic differentiation

Bacteria of the genus Streptomyces are prolific producers of specialized metabolites, including antibiotics. The linear chromosome includes a central region harboring core genes, as well as extremities enriched in specialized metabolite biosynthetic gene clusters. Here, we show that chromosome struc...

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Veröffentlicht in:	Nature communications 2021-09, Vol.12 (1), p.5221-5221, Article 5221
Hauptverfasser:	Lioy, Virginia S., Lorenzi, Jean-Noël, Najah, Soumaya, Poinsignon, Thibault, Leh, Hervé, Saulnier, Corinne, Aigle, Bertrand, Lautru, Sylvie, Thibessard, Annabelle, Lespinet, Olivier, Leblond, Pierre, Jaszczyszyn, Yan, Gorrichon, Kevin, Varoquaux, Nelle, Junier, Ivan, Boccard, Frédéric, Pernodet, Jean-Luc, Bury-Moné, Stéphanie
Format:	Artikel
Sprache:	eng
Schlagworte:	45/23 45/91 631/326/41/2530 631/326/41/88 631/443/319 631/80/103 Antibiotics Bacteria Bacteriology Biochemistry, Molecular Biology Biosynthesis Boundaries Chromosomes Conformation Differentiation Evolutionary genetics Extremities Gene clusters Gene expression Genes Genomes Genomics Humanities and Social Sciences Life Sciences Metabolism Metabolites Microbiology and Parasitology multidisciplinary Multidisciplinary Sciences Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary) Streptomyces ambofaciens Transcription
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