RESISTIVITY OF PROTEIN KINASE-B (AKT), NF-κB TRANSDUCTION OBSTACLES, AND APOPTOSIS INDUCTION (CASPACE -3, -9) AS ANTI-PROLIFERATION AND ANTI-CANCER OF BURKITT'S LYMPHOMA USING FLAVONOID FRACTION OF ETHYL ACETATE FROM ANT NEST (MYRMECODIA PENDANS)
Introduction: Burkitt's lymphoma (LB) is a tumor with high malignancy and rapid cell growth and originates from B-cell lymphoma. LB is usually found in children in endemic areas with dengue fever and HIV-AIDS with low socioeconomic levels. Objective: This research aims to analyze resistivity of...
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| description | Introduction: Burkitt's lymphoma (LB) is a tumor with high malignancy and rapid cell growth and originates from B-cell lymphoma. LB is usually found in children in endemic areas with dengue fever and HIV-AIDS with low socioeconomic levels. Objective: This research aims to analyze resistivity of protein kinase-B (Akt), NF-κB transduction obstacles, and apoptosis induction (Caspace -3, -9) as anti-proliferation and anti-cancer of burkiit's lymphoma using flavonoid fraction of ethyl acetate from ant nest (Myrmecodia pendans). Material and Methods: The study was conducted in a pure laboratory experimental method using burkitt's lymphoma cancer cell culture. Gradual research begins with the determination, extraction and fractionation of ant nest plants, to test for proliferation barriers. Data analysis using two-way ANOVA followed by Post Hoc LSD test with a significance level of 95%. Pearson correlation test was conducted. Results: Resistivity of protein expression of protein kinase-B (Akt), transcription factor of nuclear factor-kappa B (NF-κB), and apoptosis induction (Caspace -3,-9) showed increased protein expression was significantly obstacles and prove that the ethyl acetate fraction flavonoid inhibits translocation and activation of transcription pathway NF-κB and growth factors that induces the phosphorylation of Akt signal transduction pathway, and apoptosis induction (Caspace -3,-9). Conclusion: Flavonoid fraction of ethyl acetate from ant nest (Myrmecodia pendans) resistivity of protein kinase-B (Akt), NF-κB transduction obstacles, and apoptosis induction (Caspace -3, -9) as anti-proliferation and anti-cancer of burkitt's lymphoma. |
| doi_str_mv | 10.1088/1742-6596/1341/7/072001 |
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LB is usually found in children in endemic areas with dengue fever and HIV-AIDS with low socioeconomic levels. Objective: This research aims to analyze resistivity of protein kinase-B (Akt), NF-κB transduction obstacles, and apoptosis induction (Caspace -3, -9) as anti-proliferation and anti-cancer of burkiit's lymphoma using flavonoid fraction of ethyl acetate from ant nest (Myrmecodia pendans). Material and Methods: The study was conducted in a pure laboratory experimental method using burkitt's lymphoma cancer cell culture. Gradual research begins with the determination, extraction and fractionation of ant nest plants, to test for proliferation barriers. Data analysis using two-way ANOVA followed by Post Hoc LSD test with a significance level of 95%. Pearson correlation test was conducted. Results: Resistivity of protein expression of protein kinase-B (Akt), transcription factor of nuclear factor-kappa B (NF-κB), and apoptosis induction (Caspace -3,-9) showed increased protein expression was significantly obstacles and prove that the ethyl acetate fraction flavonoid inhibits translocation and activation of transcription pathway NF-κB and growth factors that induces the phosphorylation of Akt signal transduction pathway, and apoptosis induction (Caspace -3,-9). Conclusion: Flavonoid fraction of ethyl acetate from ant nest (Myrmecodia pendans) resistivity of protein kinase-B (Akt), NF-κB transduction obstacles, and apoptosis induction (Caspace -3, -9) as anti-proliferation and anti-cancer of burkitt's lymphoma.</description><identifier>ISSN: 1742-6588</identifier><identifier>EISSN: 1742-6596</identifier><identifier>DOI: 10.1088/1742-6596/1341/7/072001</identifier><language>eng</language><publisher>Bristol: IOP Publishing</publisher><subject>Ant nest ; Apoptosis ; Barriers ; Burkitt's lymphoma ; Cancer ; Data analysis ; Dengue fever ; Electrical resistivity ; Ethyl acetate ; Flavonoid fraction of ethyl acetate ; Flavonoids ; Fractionation ; Growth factors ; Kinases ; Lymphoma ; NF-κB ; Phosphorylation ; Physics ; Protein expression ; protein kinase-B (Akt) ; Proteins ; Signal transduction</subject><ispartof>Journal of physics. Conference series, 2019-10, Vol.1341 (7), p.72001</ispartof><rights>Published under licence by IOP Publishing Ltd</rights><rights>2019. This work is published under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2741-2d6a0462893c739a330c74c035f1b7ad6014b27ad19368616850fe5d623010913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://iopscience.iop.org/article/10.1088/1742-6596/1341/7/072001/pdf$$EPDF$$P50$$Giop$$Hfree_for_read</linktopdf><link.rule.ids>314,776,780,27901,27902,38845,38867,53815,53842</link.rule.ids></links><search><creatorcontrib>Achmad, Muhammad Harun</creatorcontrib><creatorcontrib>Ramadhany, Sri</creatorcontrib><creatorcontrib>Ramadhany, Yunita Feby</creatorcontrib><title>RESISTIVITY OF PROTEIN KINASE-B (AKT), NF-κB TRANSDUCTION OBSTACLES, AND APOPTOSIS INDUCTION (CASPACE -3, -9) AS ANTI-PROLIFERATION AND ANTI-CANCER OF BURKITT'S LYMPHOMA USING FLAVONOID FRACTION OF ETHYL ACETATE FROM ANT NEST (MYRMECODIA PENDANS)</title><title>Journal of physics. Conference series</title><addtitle>J. Phys.: Conf. Ser</addtitle><description>Introduction: Burkitt's lymphoma (LB) is a tumor with high malignancy and rapid cell growth and originates from B-cell lymphoma. LB is usually found in children in endemic areas with dengue fever and HIV-AIDS with low socioeconomic levels. Objective: This research aims to analyze resistivity of protein kinase-B (Akt), NF-κB transduction obstacles, and apoptosis induction (Caspace -3, -9) as anti-proliferation and anti-cancer of burkiit's lymphoma using flavonoid fraction of ethyl acetate from ant nest (Myrmecodia pendans). Material and Methods: The study was conducted in a pure laboratory experimental method using burkitt's lymphoma cancer cell culture. Gradual research begins with the determination, extraction and fractionation of ant nest plants, to test for proliferation barriers. Data analysis using two-way ANOVA followed by Post Hoc LSD test with a significance level of 95%. Pearson correlation test was conducted. Results: Resistivity of protein expression of protein kinase-B (Akt), transcription factor of nuclear factor-kappa B (NF-κB), and apoptosis induction (Caspace -3,-9) showed increased protein expression was significantly obstacles and prove that the ethyl acetate fraction flavonoid inhibits translocation and activation of transcription pathway NF-κB and growth factors that induces the phosphorylation of Akt signal transduction pathway, and apoptosis induction (Caspace -3,-9). Conclusion: Flavonoid fraction of ethyl acetate from ant nest (Myrmecodia pendans) resistivity of protein kinase-B (Akt), NF-κB transduction obstacles, and apoptosis induction (Caspace -3, -9) as anti-proliferation and anti-cancer of burkitt's lymphoma.</description><subject>Ant nest</subject><subject>Apoptosis</subject><subject>Barriers</subject><subject>Burkitt's lymphoma</subject><subject>Cancer</subject><subject>Data analysis</subject><subject>Dengue fever</subject><subject>Electrical resistivity</subject><subject>Ethyl acetate</subject><subject>Flavonoid fraction of ethyl acetate</subject><subject>Flavonoids</subject><subject>Fractionation</subject><subject>Growth factors</subject><subject>Kinases</subject><subject>Lymphoma</subject><subject>NF-κB</subject><subject>Phosphorylation</subject><subject>Physics</subject><subject>Protein expression</subject><subject>protein kinase-B (Akt)</subject><subject>Proteins</subject><subject>Signal transduction</subject><issn>1742-6588</issn><issn>1742-6596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>O3W</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkdFu0zAUhiMEEmPwDByJC9qpoXacOMmlmziraWJHsTupV1aWttImoCVhF3s1HoLX4RZnHUNISPjGRz7f_59j_Z73FqMPGCXJHMdh4NMopXNMQjyP5ygOEMLPvLOnzvOnOkleeq-G4RYh4k585v1suBbaiCthNqAKqBtluJCwEpJp7i9gwlZmOgNZ-D--L8A0TOp8nRmhJKiFNiwruZ4BkzmwWtVGOTcQ8jcyyZiuWcbBJzPw0ykw7VgjfDenFAVv2AP2IB-fMyYz3oyLLNbNShjzXkO5qeqlqhistZCXUJTsSkklciga9rhIAdwsNyW4SYYZ7jqqGg1Bcm1gUm2aimcqFwxqLnP3helr78W-_TTs3jze59664CZb-qW6FBkr_S6IQ-wHW9qikAZJSrqYpC0hqIvDDpFoj6_jdksRDq8DV-CU0IRimkRov4u2NCAIoxSTc-_dyffYH77e7YZv9vZw139xI20Q0QRFAU0TR8UnqusPw9Dv9vbY33xu-3uLkR1TtmN-dszSjinb2J5SdkpyUt4cjn-s_6-6-IfqY53pv0F73O7JLyzLomE</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Achmad, Muhammad Harun</creator><creator>Ramadhany, Sri</creator><creator>Ramadhany, Yunita Feby</creator><general>IOP Publishing</general><scope>O3W</scope><scope>TSCCA</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>H8D</scope><scope>HCIFZ</scope><scope>L7M</scope><scope>P5Z</scope><scope>P62</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20191001</creationdate><title>RESISTIVITY OF PROTEIN KINASE-B (AKT), NF-κB TRANSDUCTION OBSTACLES, AND APOPTOSIS INDUCTION (CASPACE -3, -9) AS ANTI-PROLIFERATION AND ANTI-CANCER OF BURKITT'S LYMPHOMA USING FLAVONOID FRACTION OF ETHYL ACETATE FROM ANT NEST (MYRMECODIA PENDANS)</title><author>Achmad, Muhammad Harun ; Ramadhany, Sri ; Ramadhany, Yunita Feby</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2741-2d6a0462893c739a330c74c035f1b7ad6014b27ad19368616850fe5d623010913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Ant nest</topic><topic>Apoptosis</topic><topic>Barriers</topic><topic>Burkitt's lymphoma</topic><topic>Cancer</topic><topic>Data analysis</topic><topic>Dengue fever</topic><topic>Electrical resistivity</topic><topic>Ethyl acetate</topic><topic>Flavonoid fraction of ethyl acetate</topic><topic>Flavonoids</topic><topic>Fractionation</topic><topic>Growth factors</topic><topic>Kinases</topic><topic>Lymphoma</topic><topic>NF-κB</topic><topic>Phosphorylation</topic><topic>Physics</topic><topic>Protein expression</topic><topic>protein kinase-B (Akt)</topic><topic>Proteins</topic><topic>Signal transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Achmad, Muhammad Harun</creatorcontrib><creatorcontrib>Ramadhany, Sri</creatorcontrib><creatorcontrib>Ramadhany, Yunita Feby</creatorcontrib><collection>IOP Publishing Free Content</collection><collection>IOPscience (Open Access)</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Aerospace Database</collection><collection>SciTech Premium Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Journal of physics. Conference series</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Achmad, Muhammad Harun</au><au>Ramadhany, Sri</au><au>Ramadhany, Yunita Feby</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>RESISTIVITY OF PROTEIN KINASE-B (AKT), NF-κB TRANSDUCTION OBSTACLES, AND APOPTOSIS INDUCTION (CASPACE -3, -9) AS ANTI-PROLIFERATION AND ANTI-CANCER OF BURKITT'S LYMPHOMA USING FLAVONOID FRACTION OF ETHYL ACETATE FROM ANT NEST (MYRMECODIA PENDANS)</atitle><jtitle>Journal of physics. Conference series</jtitle><addtitle>J. Phys.: Conf. Ser</addtitle><date>2019-10-01</date><risdate>2019</risdate><volume>1341</volume><issue>7</issue><spage>72001</spage><pages>72001-</pages><issn>1742-6588</issn><eissn>1742-6596</eissn><abstract>Introduction: Burkitt's lymphoma (LB) is a tumor with high malignancy and rapid cell growth and originates from B-cell lymphoma. LB is usually found in children in endemic areas with dengue fever and HIV-AIDS with low socioeconomic levels. Objective: This research aims to analyze resistivity of protein kinase-B (Akt), NF-κB transduction obstacles, and apoptosis induction (Caspace -3, -9) as anti-proliferation and anti-cancer of burkiit's lymphoma using flavonoid fraction of ethyl acetate from ant nest (Myrmecodia pendans). Material and Methods: The study was conducted in a pure laboratory experimental method using burkitt's lymphoma cancer cell culture. Gradual research begins with the determination, extraction and fractionation of ant nest plants, to test for proliferation barriers. Data analysis using two-way ANOVA followed by Post Hoc LSD test with a significance level of 95%. Pearson correlation test was conducted. Results: Resistivity of protein expression of protein kinase-B (Akt), transcription factor of nuclear factor-kappa B (NF-κB), and apoptosis induction (Caspace -3,-9) showed increased protein expression was significantly obstacles and prove that the ethyl acetate fraction flavonoid inhibits translocation and activation of transcription pathway NF-κB and growth factors that induces the phosphorylation of Akt signal transduction pathway, and apoptosis induction (Caspace -3,-9). Conclusion: Flavonoid fraction of ethyl acetate from ant nest (Myrmecodia pendans) resistivity of protein kinase-B (Akt), NF-κB transduction obstacles, and apoptosis induction (Caspace -3, -9) as anti-proliferation and anti-cancer of burkitt's lymphoma.</abstract><cop>Bristol</cop><pub>IOP Publishing</pub><doi>10.1088/1742-6596/1341/7/072001</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Ant nest Apoptosis Barriers Burkitt's lymphoma Cancer Data analysis Dengue fever Electrical resistivity Ethyl acetate Flavonoid fraction of ethyl acetate Flavonoids Fractionation Growth factors Kinases Lymphoma NF-κB Phosphorylation Physics Protein expression protein kinase-B (Akt) Proteins Signal transduction |
| title | RESISTIVITY OF PROTEIN KINASE-B (AKT), NF-κB TRANSDUCTION OBSTACLES, AND APOPTOSIS INDUCTION (CASPACE -3, -9) AS ANTI-PROLIFERATION AND ANTI-CANCER OF BURKITT'S LYMPHOMA USING FLAVONOID FRACTION OF ETHYL ACETATE FROM ANT NEST (MYRMECODIA PENDANS) |
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