MUSASHI‐2 confers resistance to third‐generation EGFR‐tyrosine kinase inhibitor osimertinib in lung adenocarcinoma

Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs) are effective in patients with non–small‐cell lung cancer (NSCLC) harboring EGFR mutations. However, due to acquired resistance to EGFR‐TKIs, even patients on third‐generation osimertinib have a poor prognosis. Resistance mechan...

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Veröffentlicht in:	Cancer science 2021-09, Vol.112 (9), p.3810-3821
Hauptverfasser:	Yiming, Reheman, Takeuchi, Yasuto, Nishimura, Tatsunori, Li, Mengjiao, Wang, Yuming, Meguro‐Horike, Makiko, Kohno, Takashi, Horike, Shin‐ichi, Nakata, Asuka, Gotoh, Noriko
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Acrylamides - pharmacology Acrylamides - therapeutic use Adenocarcinoma Adenocarcinoma of Lung - metabolism Adenocarcinoma of Lung - pathology Aldehyde dehydrogenase Analysis Aniline Compounds - pharmacology Aniline Compounds - therapeutic use Antibodies cancer stem cells Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Cell growth Cell Proliferation - drug effects Cell Survival - drug effects Cell Survival - genetics Core protein Dehydrogenases Drug resistance Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Enzyme inhibitors Epidermal growth factor Epidermal growth factor receptors ErbB Receptors - antagonists & inhibitors ErbB Receptors - genetics Gefitinib Gefitinib - pharmacology Gefitinib - therapeutic use Gene expression Gene Expression Profiling Gene Knockdown Techniques Genes Genetic aspects Humans Immunoprecipitation Kinases Life Sciences & Biomedicine Lung cancer Lung cancer, Non-small cell Lung Neoplasms - metabolism Lung Neoplasms - pathology Mutation Nanog Homeobox Protein - metabolism Non-small cell lung carcinoma non–small‐cell lung cancer Oncology Original Phenols Prognosis Protein binding Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Protein-tyrosine kinase receptors Proteins RNA RNA-binding protein RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Science & Technology Software Stem cells Transcriptome Transcriptomes Transfection Tyrosine Up-Regulation
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