Facile fabrication of diatomite‐based sponge with high biocompatibility and rapid hemostasis
Excessive bleeding causes a large part of deaths in wars and accidents. It is necessary to prepare a hemostatic material with excellent performance and low cost through a facile strategy. Herein, the diatomite is modified with (3‐Aminopropyl) triethoxysilane (APTES) to endow the aminated diatomite (...
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| Veröffentlicht in: | Journal of applied polymer science 2021-12, Vol.138 (46), p.n/a |
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| container_title | Journal of applied polymer science |
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| creator | Yang, He Ma, Zhifang Guan, Xinghua Xiang, Zehong Ke, Yue Xia, Yu Xin, Zhirong Shi, Qiang Yin, Jinghua |
| description | Excessive bleeding causes a large part of deaths in wars and accidents. It is necessary to prepare a hemostatic material with excellent performance and low cost through a facile strategy. Herein, the diatomite is modified with (3‐Aminopropyl) triethoxysilane (APTES) to endow the aminated diatomite (ADia) with positive charge and interface compatibility with chitosan (CS) and sodium alginate (SA). Then, the facile fabrication of CS/SA/ADia sponge is successfully obtained by cross‐linking with calcium ions. Compared to CS/SA sponge, the introduction of ADia further enhances the mechanical properties and hemostatic performance of CS/SA‐based sponges. The composite sponges with 30 wt% ADia are demonstrated to possess high biocompatibility, compressive strength, water adsorption, and rapid hemostatic capability both in vitro and in vivo. The hemostatic performance is interpreted by activation of coagulation factors and platelets in intrinsic pathway, promotion of blood cell adhesion and formation of fibrin network. Our work provides an effective strategy to develop rapid hemostatic materials with low cost and high efficiency. |
| doi_str_mv | 10.1002/app.51360 |
| format | Article |
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It is necessary to prepare a hemostatic material with excellent performance and low cost through a facile strategy. Herein, the diatomite is modified with (3‐Aminopropyl) triethoxysilane (APTES) to endow the aminated diatomite (ADia) with positive charge and interface compatibility with chitosan (CS) and sodium alginate (SA). Then, the facile fabrication of CS/SA/ADia sponge is successfully obtained by cross‐linking with calcium ions. Compared to CS/SA sponge, the introduction of ADia further enhances the mechanical properties and hemostatic performance of CS/SA‐based sponges. The composite sponges with 30 wt% ADia are demonstrated to possess high biocompatibility, compressive strength, water adsorption, and rapid hemostatic capability both in vitro and in vivo. The hemostatic performance is interpreted by activation of coagulation factors and platelets in intrinsic pathway, promotion of blood cell adhesion and formation of fibrin network. Our work provides an effective strategy to develop rapid hemostatic materials with low cost and high efficiency.</description><identifier>ISSN: 0021-8995</identifier><identifier>EISSN: 1097-4628</identifier><identifier>DOI: 10.1002/app.51360</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Adsorbed water ; Biocompatibility ; biomaterials ; Blood cells ; Calcium ions ; Cell adhesion ; Chitosan ; Coagulation ; Compressive strength ; degradation ; Diatomaceous earth ; Fibrin ; Hemostatics ; Low cost ; Materials science ; Mechanical properties ; Platelets ; Polymers ; porous materials ; Sodium alginate ; Sponges ; swelling</subject><ispartof>Journal of applied polymer science, 2021-12, Vol.138 (46), p.n/a</ispartof><rights>2021 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2970-b74bc3ab983166dc9e85592eec27c689d75d21e152ec190db1e0484f7a5d8f543</citedby><cites>FETCH-LOGICAL-c2970-b74bc3ab983166dc9e85592eec27c689d75d21e152ec190db1e0484f7a5d8f543</cites><orcidid>0000-0003-4431-4434</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fapp.51360$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fapp.51360$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Yang, He</creatorcontrib><creatorcontrib>Ma, Zhifang</creatorcontrib><creatorcontrib>Guan, Xinghua</creatorcontrib><creatorcontrib>Xiang, Zehong</creatorcontrib><creatorcontrib>Ke, Yue</creatorcontrib><creatorcontrib>Xia, Yu</creatorcontrib><creatorcontrib>Xin, Zhirong</creatorcontrib><creatorcontrib>Shi, Qiang</creatorcontrib><creatorcontrib>Yin, Jinghua</creatorcontrib><title>Facile fabrication of diatomite‐based sponge with high biocompatibility and rapid hemostasis</title><title>Journal of applied polymer science</title><description>Excessive bleeding causes a large part of deaths in wars and accidents. It is necessary to prepare a hemostatic material with excellent performance and low cost through a facile strategy. Herein, the diatomite is modified with (3‐Aminopropyl) triethoxysilane (APTES) to endow the aminated diatomite (ADia) with positive charge and interface compatibility with chitosan (CS) and sodium alginate (SA). Then, the facile fabrication of CS/SA/ADia sponge is successfully obtained by cross‐linking with calcium ions. Compared to CS/SA sponge, the introduction of ADia further enhances the mechanical properties and hemostatic performance of CS/SA‐based sponges. The composite sponges with 30 wt% ADia are demonstrated to possess high biocompatibility, compressive strength, water adsorption, and rapid hemostatic capability both in vitro and in vivo. The hemostatic performance is interpreted by activation of coagulation factors and platelets in intrinsic pathway, promotion of blood cell adhesion and formation of fibrin network. Our work provides an effective strategy to develop rapid hemostatic materials with low cost and high efficiency.</description><subject>Adsorbed water</subject><subject>Biocompatibility</subject><subject>biomaterials</subject><subject>Blood cells</subject><subject>Calcium ions</subject><subject>Cell adhesion</subject><subject>Chitosan</subject><subject>Coagulation</subject><subject>Compressive strength</subject><subject>degradation</subject><subject>Diatomaceous earth</subject><subject>Fibrin</subject><subject>Hemostatics</subject><subject>Low cost</subject><subject>Materials science</subject><subject>Mechanical properties</subject><subject>Platelets</subject><subject>Polymers</subject><subject>porous materials</subject><subject>Sodium alginate</subject><subject>Sponges</subject><subject>swelling</subject><issn>0021-8995</issn><issn>1097-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kLtOwzAYhS0EEqUw8AaWmBjS2k7sxGNVcZMq0QFWLN_SuGpiY6equvEIPCNPQiCsTP9wvnN-6QPgGqMZRojMZQgzinOGTsAEI15mBSPVKZgMGc4qzuk5uEhpixDGFLEJeLuX2u0srKWKTsve-Q76Ghone9-63n59fCqZrIEp-G5j4cH1DWzcpoHKee3bMFSU27n-CGVnYJTBGdjY1qdeJpcuwVktd8le_d0peL2_e1k-Zqvnh6flYpVpwkuUqbJQOpeKVzlmzGhuK0o5sVaTUrOKm5Iagi2mxGrMkVHYoqIq6lJSU9W0yKfgZtwN0b_vberF1u9jN7wUhLKSF4wSMlC3I6WjTynaWoToWhmPAiPxo08M-sSvvoGdj-xh0HP8HxSL9XpsfAM1i3Mi</recordid><startdate>20211210</startdate><enddate>20211210</enddate><creator>Yang, He</creator><creator>Ma, Zhifang</creator><creator>Guan, Xinghua</creator><creator>Xiang, Zehong</creator><creator>Ke, Yue</creator><creator>Xia, Yu</creator><creator>Xin, Zhirong</creator><creator>Shi, Qiang</creator><creator>Yin, Jinghua</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><orcidid>https://orcid.org/0000-0003-4431-4434</orcidid></search><sort><creationdate>20211210</creationdate><title>Facile fabrication of diatomite‐based sponge with high biocompatibility and rapid hemostasis</title><author>Yang, He ; Ma, Zhifang ; Guan, Xinghua ; Xiang, Zehong ; Ke, Yue ; Xia, Yu ; Xin, Zhirong ; Shi, Qiang ; Yin, Jinghua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2970-b74bc3ab983166dc9e85592eec27c689d75d21e152ec190db1e0484f7a5d8f543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adsorbed water</topic><topic>Biocompatibility</topic><topic>biomaterials</topic><topic>Blood cells</topic><topic>Calcium ions</topic><topic>Cell adhesion</topic><topic>Chitosan</topic><topic>Coagulation</topic><topic>Compressive strength</topic><topic>degradation</topic><topic>Diatomaceous earth</topic><topic>Fibrin</topic><topic>Hemostatics</topic><topic>Low cost</topic><topic>Materials science</topic><topic>Mechanical properties</topic><topic>Platelets</topic><topic>Polymers</topic><topic>porous materials</topic><topic>Sodium alginate</topic><topic>Sponges</topic><topic>swelling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, He</creatorcontrib><creatorcontrib>Ma, Zhifang</creatorcontrib><creatorcontrib>Guan, Xinghua</creatorcontrib><creatorcontrib>Xiang, Zehong</creatorcontrib><creatorcontrib>Ke, Yue</creatorcontrib><creatorcontrib>Xia, Yu</creatorcontrib><creatorcontrib>Xin, Zhirong</creatorcontrib><creatorcontrib>Shi, Qiang</creatorcontrib><creatorcontrib>Yin, Jinghua</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Journal of applied polymer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, He</au><au>Ma, Zhifang</au><au>Guan, Xinghua</au><au>Xiang, Zehong</au><au>Ke, Yue</au><au>Xia, Yu</au><au>Xin, Zhirong</au><au>Shi, Qiang</au><au>Yin, Jinghua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Facile fabrication of diatomite‐based sponge with high biocompatibility and rapid hemostasis</atitle><jtitle>Journal of applied polymer science</jtitle><date>2021-12-10</date><risdate>2021</risdate><volume>138</volume><issue>46</issue><epage>n/a</epage><issn>0021-8995</issn><eissn>1097-4628</eissn><abstract>Excessive bleeding causes a large part of deaths in wars and accidents. It is necessary to prepare a hemostatic material with excellent performance and low cost through a facile strategy. Herein, the diatomite is modified with (3‐Aminopropyl) triethoxysilane (APTES) to endow the aminated diatomite (ADia) with positive charge and interface compatibility with chitosan (CS) and sodium alginate (SA). Then, the facile fabrication of CS/SA/ADia sponge is successfully obtained by cross‐linking with calcium ions. Compared to CS/SA sponge, the introduction of ADia further enhances the mechanical properties and hemostatic performance of CS/SA‐based sponges. The composite sponges with 30 wt% ADia are demonstrated to possess high biocompatibility, compressive strength, water adsorption, and rapid hemostatic capability both in vitro and in vivo. The hemostatic performance is interpreted by activation of coagulation factors and platelets in intrinsic pathway, promotion of blood cell adhesion and formation of fibrin network. Our work provides an effective strategy to develop rapid hemostatic materials with low cost and high efficiency.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><doi>10.1002/app.51360</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-4431-4434</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Adsorbed water Biocompatibility biomaterials Blood cells Calcium ions Cell adhesion Chitosan Coagulation Compressive strength degradation Diatomaceous earth Fibrin Hemostatics Low cost Materials science Mechanical properties Platelets Polymers porous materials Sodium alginate Sponges swelling |
| title | Facile fabrication of diatomite‐based sponge with high biocompatibility and rapid hemostasis |
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