Global REACH 2018: the adaptive phenotype to life with chronic mountain sickness and polycythaemia

Key points Humans suffering from polycythaemia undergo multiple circulatory adaptations including changes in blood rheology and structural and functional vascular adaptations to maintain normal blood pressure and vascular shear stresses, despite high blood viscosity. During exercise, several circula...

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Veröffentlicht in:	The Journal of physiology 2021-09, Vol.599 (17), p.4021-4044
Hauptverfasser:	Hansen, Alexander B., Moralez, Gilbert, Amin, Sachin B., Simspon, Lydia L., Hofstaetter, Florian, Anholm, James D, Gasho, Christopher, Stembridge, Mike, Dawkins, Tony G., Tymko, Michael M., Ainslie, Philip N., Villafuerte, Francisco, Romero, Steven A., Hearon, Christopher M., Lawley, Justin S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation Aerobic capacity Altitude Blood pressure Cell size chronic mountain sickness Contraction Erythrocytes Exercise exercise haemodynamics Heart Hematocrit Hemoglobin Musculoskeletal system Natural selection neurovascular transduction Phenotypes Polycythemia Rheology Signal transduction Skeletal muscle Sympathetic nerves sympathetic nervous system Viscosity α‐adrenergic receptors
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