The activity of casein derived from goat milk yogurt as an antioxidant on histopathology of rat's liver exposure by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a toxic contaminant which persistent in the environment. Accumulation of this compound on the body through food chain can generate adverse effect in human health. The aim of this research was to observe the activity of casein derived from goat milk. A total of twenty-four male Wistar rats of twelve weeks old were used in this research. The rats were divided into six groups: (1) control group, (2) placebo group which given casein 600 mg/kgBW, (3) TCDD group given with TCDD 100 ng/kgBW, group P1 given casein 300 mg/kgBW and TCDD, (5) group P2 given casein 600 mg/kgBW and TCDD, (6) group P3 given casein 900 mg/kgBW and TCDD. Provision of casein and TCDD were given orally for 21 days. Liver sample collected for histopathological examination with hematoxylin Eosin (HE) stained. Experimental method was based on completely randomized design. The histopathological were analyzed by Kruskal-Wallis test followed by Mann-Whitney test to know the differences of the treatments. Result of the research showed that casein could protect the rat liver from damage in TCDD intoxicated rats. Significant increase (P