Endocavity Histotripsy for Efficient Tissue Ablation-Transducer Design and Characterization
A 34-mm aperture transducer was designed and tested for proof of concept to ablate tissues using an endocavity histotripsy device. Several materials and two drivers were modeled and tested to determine an effective piezoelectric-matching layer combination and driver design. The resulting transducer...
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| Veröffentlicht in: | IEEE transactions on ultrasonics, ferroelectrics, and frequency control ferroelectrics, and frequency control, 2021-09, Vol.68 (9), p.2896-2905 |
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| container_title | IEEE transactions on ultrasonics, ferroelectrics, and frequency control |
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| creator | Stocker, Greyson E. Zhang, Man Xu, Zhen Hall, Timothy L. |
| description | A 34-mm aperture transducer was designed and tested for proof of concept to ablate tissues using an endocavity histotripsy device. Several materials and two drivers were modeled and tested to determine an effective piezoelectric-matching layer combination and driver design. The resulting transducer was fabricated using 1.5 MHz porous PZT and PerFORM 3-D printed acoustic lenses and was driven with a multicycle class-D amplifier. The lower frequency, compared to previously developed small form factor histotripsy transducers, was selected to allow for more efficient volume ablation of tissue. The transducer was characterized and tested by measuring pressure field maps in the axial and lateral planes and pressure output as a function of driving voltage. The axial and lateral full-width-half-maximums of the focus were found to be 6.1 and 1.1 mm, respectively. The transducer was estimated to generate 34.5-MPa peak negative focal pressure with a peak-to-peak driving voltage of 1345 V. Performance testing was done by ablating volumes of bovine liver tissues ( {n} = {3} ). The transducer was found to be capable of ablating tissues at its full working distance of 17 mm. |
| doi_str_mv | 10.1109/TUFFC.2021.3055138 |
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Several materials and two drivers were modeled and tested to determine an effective piezoelectric-matching layer combination and driver design. The resulting transducer was fabricated using 1.5 MHz porous PZT and PerFORM 3-D printed acoustic lenses and was driven with a multicycle class-D amplifier. The lower frequency, compared to previously developed small form factor histotripsy transducers, was selected to allow for more efficient volume ablation of tissue. The transducer was characterized and tested by measuring pressure field maps in the axial and lateral planes and pressure output as a function of driving voltage. The axial and lateral full-width-half-maximums of the focus were found to be 6.1 and 1.1 mm, respectively. The transducer was estimated to generate 34.5-MPa peak negative focal pressure with a peak-to-peak driving voltage of 1345 V. Performance testing was done by ablating volumes of bovine liver tissues (<inline-formula> <tex-math notation="LaTeX">{n} = {3} </tex-math></inline-formula>). The transducer was found to be capable of ablating tissues at its full working distance of 17 mm.</description><identifier>ISSN: 0885-3010</identifier><identifier>ISSN: 1525-8955</identifier><identifier>EISSN: 1525-8955</identifier><identifier>DOI: 10.1109/TUFFC.2021.3055138</identifier><identifier>PMID: 33507869</identifier><identifier>CODEN: ITUCER</identifier><language>eng</language><publisher>United States: IEEE</publisher><subject>Ablation ; Acoustics ; Animals ; Cattle ; Electric potential ; Endocavity ; Equipment Design ; Form factors ; High-Intensity Focused Ultrasound Ablation ; histotripsy ; Lenses ; Liver - diagnostic imaging ; Liver - surgery ; Matching layers (electronics) ; Piezoelectricity ; Surface impedance ; Testing ; Three dimensional printing ; Three-dimensional displays ; tissue ablation ; Transducers ; ultrasound ; Voltage ; Voltage measurement</subject><ispartof>IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2021-09, Vol.68 (9), p.2896-2905</ispartof><rights>Copyright The Institute of Electrical and Electronics Engineers, Inc. (IEEE) 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-daa868b89777748d19b6e230b82ac7996b80ac5c47a6972ac868a678497b46523</citedby><cites>FETCH-LOGICAL-c450t-daa868b89777748d19b6e230b82ac7996b80ac5c47a6972ac868a678497b46523</cites><orcidid>0000-0003-0262-3044 ; 0000-0001-7241-899X ; 0000-0002-4867-2856</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://ieeexplore.ieee.org/document/9339873$$EHTML$$P50$$Gieee$$H</linktohtml><link.rule.ids>230,314,780,784,796,885,27915,27916,54749</link.rule.ids><linktorsrc>$$Uhttps://ieeexplore.ieee.org/document/9339873$$EView_record_in_IEEE$$FView_record_in_$$GIEEE</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33507869$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stocker, Greyson E.</creatorcontrib><creatorcontrib>Zhang, Man</creatorcontrib><creatorcontrib>Xu, Zhen</creatorcontrib><creatorcontrib>Hall, Timothy L.</creatorcontrib><title>Endocavity Histotripsy for Efficient Tissue Ablation-Transducer Design and Characterization</title><title>IEEE transactions on ultrasonics, ferroelectrics, and frequency control</title><addtitle>T-UFFC</addtitle><addtitle>IEEE Trans Ultrason Ferroelectr Freq Control</addtitle><description>A 34-mm aperture transducer was designed and tested for proof of concept to ablate tissues using an endocavity histotripsy device. Several materials and two drivers were modeled and tested to determine an effective piezoelectric-matching layer combination and driver design. The resulting transducer was fabricated using 1.5 MHz porous PZT and PerFORM 3-D printed acoustic lenses and was driven with a multicycle class-D amplifier. The lower frequency, compared to previously developed small form factor histotripsy transducers, was selected to allow for more efficient volume ablation of tissue. The transducer was characterized and tested by measuring pressure field maps in the axial and lateral planes and pressure output as a function of driving voltage. The axial and lateral full-width-half-maximums of the focus were found to be 6.1 and 1.1 mm, respectively. The transducer was estimated to generate 34.5-MPa peak negative focal pressure with a peak-to-peak driving voltage of 1345 V. Performance testing was done by ablating volumes of bovine liver tissues (<inline-formula> <tex-math notation="LaTeX">{n} = {3} </tex-math></inline-formula>). The transducer was found to be capable of ablating tissues at its full working distance of 17 mm.</description><subject>Ablation</subject><subject>Acoustics</subject><subject>Animals</subject><subject>Cattle</subject><subject>Electric potential</subject><subject>Endocavity</subject><subject>Equipment Design</subject><subject>Form factors</subject><subject>High-Intensity Focused Ultrasound Ablation</subject><subject>histotripsy</subject><subject>Lenses</subject><subject>Liver - diagnostic imaging</subject><subject>Liver - surgery</subject><subject>Matching layers (electronics)</subject><subject>Piezoelectricity</subject><subject>Surface impedance</subject><subject>Testing</subject><subject>Three dimensional printing</subject><subject>Three-dimensional displays</subject><subject>tissue ablation</subject><subject>Transducers</subject><subject>ultrasound</subject><subject>Voltage</subject><subject>Voltage measurement</subject><issn>0885-3010</issn><issn>1525-8955</issn><issn>1525-8955</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>RIE</sourceid><sourceid>EIF</sourceid><recordid>eNpdkU9rGzEQxUVpaNykX6CFstBLL-vo70q6FIJrN4VALs6pBzGr1SYKa8mVdgPup68cu6btXAZmfvN4w0PoPcFzQrC-Wt-vVos5xZTMGRaCMPUKzYigolZaiNdohpUSNcMEn6O3OT9hTDjX9A06Z0xgqRo9Qz-WoYsWnv24q258HuOY_Dbvqj6matn33noXxmrtc55cdd0OMPoY6nWCkLvJulR9ddk_hApCVy0eIYEdXfK_XrBLdNbDkN27Y79A96vlenFT3959-764vq0tF3isOwDVqFZpWYqrjui2cZThVlGwUuumVRissFxCo2WZFRoaqbiWLW8EZRfoy0F3O7Ub19niOMFgtslvIO1MBG_-3QT_aB7is1FcEMpZEfh8FEjx5-TyaDY-WzcMEFycsqFcMUWkoLign_5Dn-KUQnnPULE301C9d0QPlE0x5-T6kxmCzT4785Kd2WdnjtmVo49_v3E6-RNWAT4cAO-cO601Y1pJxn4D72ieoQ</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Stocker, Greyson E.</creator><creator>Zhang, Man</creator><creator>Xu, Zhen</creator><creator>Hall, Timothy L.</creator><general>IEEE</general><general>The Institute of Electrical and Electronics Engineers, Inc. (IEEE)</general><scope>97E</scope><scope>RIA</scope><scope>RIE</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>L7M</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0262-3044</orcidid><orcidid>https://orcid.org/0000-0001-7241-899X</orcidid><orcidid>https://orcid.org/0000-0002-4867-2856</orcidid></search><sort><creationdate>20210901</creationdate><title>Endocavity Histotripsy for Efficient Tissue Ablation-Transducer Design and Characterization</title><author>Stocker, Greyson E. ; Zhang, Man ; Xu, Zhen ; Hall, Timothy L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-daa868b89777748d19b6e230b82ac7996b80ac5c47a6972ac868a678497b46523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Ablation</topic><topic>Acoustics</topic><topic>Animals</topic><topic>Cattle</topic><topic>Electric potential</topic><topic>Endocavity</topic><topic>Equipment Design</topic><topic>Form factors</topic><topic>High-Intensity Focused Ultrasound Ablation</topic><topic>histotripsy</topic><topic>Lenses</topic><topic>Liver - diagnostic imaging</topic><topic>Liver - surgery</topic><topic>Matching layers (electronics)</topic><topic>Piezoelectricity</topic><topic>Surface impedance</topic><topic>Testing</topic><topic>Three dimensional printing</topic><topic>Three-dimensional displays</topic><topic>tissue ablation</topic><topic>Transducers</topic><topic>ultrasound</topic><topic>Voltage</topic><topic>Voltage measurement</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stocker, Greyson E.</creatorcontrib><creatorcontrib>Zhang, Man</creatorcontrib><creatorcontrib>Xu, Zhen</creatorcontrib><creatorcontrib>Hall, Timothy L.</creatorcontrib><collection>IEEE All-Society Periodicals Package (ASPP) 2005-present</collection><collection>IEEE All-Society Periodicals Package (ASPP) 1998–Present</collection><collection>IEEE/IET Electronic Library</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>IEEE transactions on ultrasonics, ferroelectrics, and frequency control</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Stocker, Greyson E.</au><au>Zhang, Man</au><au>Xu, Zhen</au><au>Hall, Timothy L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endocavity Histotripsy for Efficient Tissue Ablation-Transducer Design and Characterization</atitle><jtitle>IEEE transactions on ultrasonics, ferroelectrics, and frequency control</jtitle><stitle>T-UFFC</stitle><addtitle>IEEE Trans Ultrason Ferroelectr Freq Control</addtitle><date>2021-09-01</date><risdate>2021</risdate><volume>68</volume><issue>9</issue><spage>2896</spage><epage>2905</epage><pages>2896-2905</pages><issn>0885-3010</issn><issn>1525-8955</issn><eissn>1525-8955</eissn><coden>ITUCER</coden><abstract>A 34-mm aperture transducer was designed and tested for proof of concept to ablate tissues using an endocavity histotripsy device. Several materials and two drivers were modeled and tested to determine an effective piezoelectric-matching layer combination and driver design. The resulting transducer was fabricated using 1.5 MHz porous PZT and PerFORM 3-D printed acoustic lenses and was driven with a multicycle class-D amplifier. The lower frequency, compared to previously developed small form factor histotripsy transducers, was selected to allow for more efficient volume ablation of tissue. The transducer was characterized and tested by measuring pressure field maps in the axial and lateral planes and pressure output as a function of driving voltage. The axial and lateral full-width-half-maximums of the focus were found to be 6.1 and 1.1 mm, respectively. The transducer was estimated to generate 34.5-MPa peak negative focal pressure with a peak-to-peak driving voltage of 1345 V. Performance testing was done by ablating volumes of bovine liver tissues (<inline-formula> <tex-math notation="LaTeX">{n} = {3} </tex-math></inline-formula>). The transducer was found to be capable of ablating tissues at its full working distance of 17 mm.</abstract><cop>United States</cop><pub>IEEE</pub><pmid>33507869</pmid><doi>10.1109/TUFFC.2021.3055138</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-0262-3044</orcidid><orcidid>https://orcid.org/0000-0001-7241-899X</orcidid><orcidid>https://orcid.org/0000-0002-4867-2856</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2021-09, Vol.68 (9), p.2896-2905 |
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| subjects | Ablation Acoustics Animals Cattle Electric potential Endocavity Equipment Design Form factors High-Intensity Focused Ultrasound Ablation histotripsy Lenses Liver - diagnostic imaging Liver - surgery Matching layers (electronics) Piezoelectricity Surface impedance Testing Three dimensional printing Three-dimensional displays tissue ablation Transducers ultrasound Voltage Voltage measurement |
| title | Endocavity Histotripsy for Efficient Tissue Ablation-Transducer Design and Characterization |
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