Combination of ARE and HRE cis-Regulatory Elements Elevates the Activity of Tumor-Specific hTERT Promoter

Tumor-specific promoters and cis -regulatory genetic elements are used for transcriptional control of therapeutic transgene expression in cancer gene therapy. HRE (hypoxia response element) and ARE (antioxidant response element) cis -regulatory elements are targets for HIF1 and Nrf2 transcriptional...

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Veröffentlicht in:	Molecular biology (New York) 2021-07, Vol.55 (4), p.555-564
Hauptverfasser:	Kalinichenko, S. V., Korobko, I. V., Shepelev, M. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants Biochemistry Biomedical and Life Sciences Cytosine Cytosine deaminase Cytotoxicity Gene therapy Genomics. Transcriptomics Human Genetics Hypoxia Life Sciences Lung cancer Oncolysis Oxidative stress Promoters Regulatory sequences Replication Solid tumors Suicide Suicide genes Telomerase reverse transcriptase Transcription activation Transcription factors Tumor cell lines Uracil
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