Strength, corrosion resistance, and biocompatibility of ultrafine-grained Mg alloys after different modes of severe plastic deformation
The effect of severe plastic deformation on the structure, mechanical properties, corrosion resistance, and biocompatibility of the WE43 (Mg-Y-Nd-Zr) alloy earmarked for applications as bioresorbable material has been studied. The alloy was deformed by rotary swaging (RS), equal channel angular pres...
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| creator | Dobatkin, S V Lukyanova, E A Martynenko, N S Anisimova, N Yu Kiselevskiy, M V Gorshenkov, M V Yurchenko, N Yu Raab, G I Yusupov, V S Birbilis, N Salishchev, G A Estrin, Y Z |
| description | The effect of severe plastic deformation on the structure, mechanical properties, corrosion resistance, and biocompatibility of the WE43 (Mg-Y-Nd-Zr) alloy earmarked for applications as bioresorbable material has been studied. The alloy was deformed by rotary swaging (RS), equal channel angular pressing (ECAP), and multiaxial deformation (MAD). The microstructure examination by transmission electron microscopy showed that all SPD modes lead to the formation of ultrafine-grained structure with a structural element size of 0.5-1 µm and the Mg12Nd phase particles 0.3 µm in size. The microstructure refinement by all three treatments resulted in strengthening of the alloy. ECAP and MAD also raised ductility to up to 12-17%, while RS increased the ultimate tensile strength to up to 415 MPa. The study of the corrosion properties showed that SPD does not affect the electrochemical corrosion of the alloy. Its biocompatibility in vitro was estimated after incubation of the samples with red blood cells (hemolysis study), white blood cells (cell viability assay), and mesenchymal stromal cells (cell proliferation analysis). The biodegradation rate in fetal bovine serum was also evaluated. ECAP and MAD were found to cause some deceleration of biodegradation by slowing down the gas formation in the biological fluid and, compared to MSC, to improve the biocompatibility of the WE43 alloy. |
| doi_str_mv | 10.1088/1757-899X/194/1/012004 |
| format | Article |
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The alloy was deformed by rotary swaging (RS), equal channel angular pressing (ECAP), and multiaxial deformation (MAD). The microstructure examination by transmission electron microscopy showed that all SPD modes lead to the formation of ultrafine-grained structure with a structural element size of 0.5-1 µm and the Mg12Nd phase particles 0.3 µm in size. The microstructure refinement by all three treatments resulted in strengthening of the alloy. ECAP and MAD also raised ductility to up to 12-17%, while RS increased the ultimate tensile strength to up to 415 MPa. The study of the corrosion properties showed that SPD does not affect the electrochemical corrosion of the alloy. Its biocompatibility in vitro was estimated after incubation of the samples with red blood cells (hemolysis study), white blood cells (cell viability assay), and mesenchymal stromal cells (cell proliferation analysis). The biodegradation rate in fetal bovine serum was also evaluated. ECAP and MAD were found to cause some deceleration of biodegradation by slowing down the gas formation in the biological fluid and, compared to MSC, to improve the biocompatibility of the WE43 alloy.</description><identifier>ISSN: 1757-8981</identifier><identifier>EISSN: 1757-899X</identifier><identifier>DOI: 10.1088/1757-899X/194/1/012004</identifier><language>eng</language><publisher>Bristol: IOP Publishing</publisher><subject>Alloys ; Biocompatibility ; Biodegradation ; Biomedical materials ; Corrosion effects ; Corrosion resistance ; Corrosion resistant alloys ; Corrosion tests ; Deceleration ; Deformation effects ; Electrochemical corrosion ; Equal channel angular pressing ; Erythrocytes ; Gas formation ; Leukocytes ; Magnesium base alloys ; Mechanical properties ; Microstructure ; Plastic deformation ; Rotary swaging ; Structural members ; Swaging ; Ultimate tensile strength ; Ultrafines ; Zirconium</subject><ispartof>IOP conference series. Materials Science and Engineering, 2017-05, Vol.194 (1), p.12004</ispartof><rights>Published under licence by IOP Publishing Ltd</rights><rights>2017. This work is published under http://creativecommons.org/licenses/by/3.0/ (the “License”). 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Materials Science and Engineering</title><addtitle>IOP Conf. Ser.: Mater. Sci. Eng</addtitle><description>The effect of severe plastic deformation on the structure, mechanical properties, corrosion resistance, and biocompatibility of the WE43 (Mg-Y-Nd-Zr) alloy earmarked for applications as bioresorbable material has been studied. The alloy was deformed by rotary swaging (RS), equal channel angular pressing (ECAP), and multiaxial deformation (MAD). The microstructure examination by transmission electron microscopy showed that all SPD modes lead to the formation of ultrafine-grained structure with a structural element size of 0.5-1 µm and the Mg12Nd phase particles 0.3 µm in size. The microstructure refinement by all three treatments resulted in strengthening of the alloy. ECAP and MAD also raised ductility to up to 12-17%, while RS increased the ultimate tensile strength to up to 415 MPa. The study of the corrosion properties showed that SPD does not affect the electrochemical corrosion of the alloy. Its biocompatibility in vitro was estimated after incubation of the samples with red blood cells (hemolysis study), white blood cells (cell viability assay), and mesenchymal stromal cells (cell proliferation analysis). The biodegradation rate in fetal bovine serum was also evaluated. ECAP and MAD were found to cause some deceleration of biodegradation by slowing down the gas formation in the biological fluid and, compared to MSC, to improve the biocompatibility of the WE43 alloy.</description><subject>Alloys</subject><subject>Biocompatibility</subject><subject>Biodegradation</subject><subject>Biomedical materials</subject><subject>Corrosion effects</subject><subject>Corrosion resistance</subject><subject>Corrosion resistant alloys</subject><subject>Corrosion tests</subject><subject>Deceleration</subject><subject>Deformation effects</subject><subject>Electrochemical corrosion</subject><subject>Equal channel angular pressing</subject><subject>Erythrocytes</subject><subject>Gas formation</subject><subject>Leukocytes</subject><subject>Magnesium base alloys</subject><subject>Mechanical properties</subject><subject>Microstructure</subject><subject>Plastic deformation</subject><subject>Rotary swaging</subject><subject>Structural members</subject><subject>Swaging</subject><subject>Ultimate tensile strength</subject><subject>Ultrafines</subject><subject>Zirconium</subject><issn>1757-8981</issn><issn>1757-899X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>O3W</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkMtKAzEUhgdRsFZfQQJuXHRsMs1MJksp9QItLqrgLqTJSU2ZTsYkFfoEvrYplYoguDq5_P934MuyS4JvCK7rIWEly2vOX4eE0yEZYlJgTI-y3uHj-HCuyWl2FsIK44pRinvZ5zx6aJfxbYCU894F61rkIdgQZatggGSr0cI65dadjHZhGxu3yBm0aaKXxraQL71MQ6PZEsmmcduApIngkbbGQIJHtHYawq4U4CO9oK6RIVqFNBjn1wnr2vPsxMgmwMX37Gcvd5Pn8UM-fbp_HN9Oc1UWVcx1TdiILDDUrFoYTgvFQWlW0IIDqcqy0hQryokk6cook0YraUxV1kAoAIz62dWe23n3voEQxcptfJtWiqKsaMk5Z2VKVfuUSkaCByM6b9fSbwXBYidd7HyKnVuRpAsi9tJT8XpftK77Ic_mk18x0WmTosUf0X_4XwuvlIw</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Dobatkin, S V</creator><creator>Lukyanova, E A</creator><creator>Martynenko, N S</creator><creator>Anisimova, N Yu</creator><creator>Kiselevskiy, M V</creator><creator>Gorshenkov, M V</creator><creator>Yurchenko, N Yu</creator><creator>Raab, G I</creator><creator>Yusupov, V S</creator><creator>Birbilis, N</creator><creator>Salishchev, G A</creator><creator>Estrin, Y Z</creator><general>IOP Publishing</general><scope>O3W</scope><scope>TSCCA</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>L6V</scope><scope>M7S</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope></search><sort><creationdate>20170501</creationdate><title>Strength, corrosion resistance, and biocompatibility of ultrafine-grained Mg alloys after different modes of severe plastic deformation</title><author>Dobatkin, S V ; Lukyanova, E A ; Martynenko, N S ; Anisimova, N Yu ; Kiselevskiy, M V ; Gorshenkov, M V ; Yurchenko, N Yu ; Raab, G I ; Yusupov, V S ; Birbilis, N ; Salishchev, G A ; Estrin, Y Z</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-d81731b0e876bf942c9ecd72429e16556d40c491a1e16747afdcaff658e14eee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Alloys</topic><topic>Biocompatibility</topic><topic>Biodegradation</topic><topic>Biomedical materials</topic><topic>Corrosion effects</topic><topic>Corrosion resistance</topic><topic>Corrosion resistant alloys</topic><topic>Corrosion tests</topic><topic>Deceleration</topic><topic>Deformation effects</topic><topic>Electrochemical corrosion</topic><topic>Equal channel angular pressing</topic><topic>Erythrocytes</topic><topic>Gas formation</topic><topic>Leukocytes</topic><topic>Magnesium base alloys</topic><topic>Mechanical properties</topic><topic>Microstructure</topic><topic>Plastic deformation</topic><topic>Rotary swaging</topic><topic>Structural members</topic><topic>Swaging</topic><topic>Ultimate tensile strength</topic><topic>Ultrafines</topic><topic>Zirconium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dobatkin, S V</creatorcontrib><creatorcontrib>Lukyanova, E A</creatorcontrib><creatorcontrib>Martynenko, N S</creatorcontrib><creatorcontrib>Anisimova, N Yu</creatorcontrib><creatorcontrib>Kiselevskiy, M V</creatorcontrib><creatorcontrib>Gorshenkov, M V</creatorcontrib><creatorcontrib>Yurchenko, N Yu</creatorcontrib><creatorcontrib>Raab, G I</creatorcontrib><creatorcontrib>Yusupov, V S</creatorcontrib><creatorcontrib>Birbilis, N</creatorcontrib><creatorcontrib>Salishchev, G A</creatorcontrib><creatorcontrib>Estrin, Y Z</creatorcontrib><collection>IOP Publishing Free Content</collection><collection>IOPscience (Open Access)</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Science Database</collection><collection>ProQuest Engineering Collection</collection><collection>Engineering Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><jtitle>IOP conference series. Materials Science and Engineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dobatkin, S V</au><au>Lukyanova, E A</au><au>Martynenko, N S</au><au>Anisimova, N Yu</au><au>Kiselevskiy, M V</au><au>Gorshenkov, M V</au><au>Yurchenko, N Yu</au><au>Raab, G I</au><au>Yusupov, V S</au><au>Birbilis, N</au><au>Salishchev, G A</au><au>Estrin, Y Z</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Strength, corrosion resistance, and biocompatibility of ultrafine-grained Mg alloys after different modes of severe plastic deformation</atitle><jtitle>IOP conference series. Materials Science and Engineering</jtitle><addtitle>IOP Conf. Ser.: Mater. Sci. Eng</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>194</volume><issue>1</issue><spage>12004</spage><pages>12004-</pages><issn>1757-8981</issn><eissn>1757-899X</eissn><abstract>The effect of severe plastic deformation on the structure, mechanical properties, corrosion resistance, and biocompatibility of the WE43 (Mg-Y-Nd-Zr) alloy earmarked for applications as bioresorbable material has been studied. The alloy was deformed by rotary swaging (RS), equal channel angular pressing (ECAP), and multiaxial deformation (MAD). The microstructure examination by transmission electron microscopy showed that all SPD modes lead to the formation of ultrafine-grained structure with a structural element size of 0.5-1 µm and the Mg12Nd phase particles 0.3 µm in size. The microstructure refinement by all three treatments resulted in strengthening of the alloy. ECAP and MAD also raised ductility to up to 12-17%, while RS increased the ultimate tensile strength to up to 415 MPa. The study of the corrosion properties showed that SPD does not affect the electrochemical corrosion of the alloy. Its biocompatibility in vitro was estimated after incubation of the samples with red blood cells (hemolysis study), white blood cells (cell viability assay), and mesenchymal stromal cells (cell proliferation analysis). The biodegradation rate in fetal bovine serum was also evaluated. ECAP and MAD were found to cause some deceleration of biodegradation by slowing down the gas formation in the biological fluid and, compared to MSC, to improve the biocompatibility of the WE43 alloy.</abstract><cop>Bristol</cop><pub>IOP Publishing</pub><doi>10.1088/1757-899X/194/1/012004</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Alloys Biocompatibility Biodegradation Biomedical materials Corrosion effects Corrosion resistance Corrosion resistant alloys Corrosion tests Deceleration Deformation effects Electrochemical corrosion Equal channel angular pressing Erythrocytes Gas formation Leukocytes Magnesium base alloys Mechanical properties Microstructure Plastic deformation Rotary swaging Structural members Swaging Ultimate tensile strength Ultrafines Zirconium |
| title | Strength, corrosion resistance, and biocompatibility of ultrafine-grained Mg alloys after different modes of severe plastic deformation |
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