Dynamic monitoring of glycine crystallisation with low power ultrasound reflection spectroscopy
•A improved ultrasound technique is shown to accurately monitor crystallisation.•The optical cloud point can be determined using ultrasound with high accuracy.•Results agree closely with standard optical turbidity.•The ultrasound technique may be detecting scattering bodies in the metastable zone.•T...
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Veröffentlicht in: | Chemical engineering research & design 2021-06, Vol.170, p.213-223 |
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creator | Morris, Liam Simone, Elena Glover, Zachary J. Powell, Hugh Marty-Terrade, Stéphanie Francis, Mathew Povey, Megan J. |
description | •A improved ultrasound technique is shown to accurately monitor crystallisation.•The optical cloud point can be determined using ultrasound with high accuracy.•Results agree closely with standard optical turbidity.•The ultrasound technique may be detecting scattering bodies in the metastable zone.•The technique may give more information than optical techniques and be used to study structures.
Crystallisation processes are ubiquitous in the food and pharmaceutical industries and the development of process analytical technologies (PAT) for on-line, in situ monitoring is essential to ensure process efficiency and to optimise product quality. Current PAT, many of which are based on electromagnetic waves, have a range of limitations including an inability to accurately measure opaque solutions. Low power ( |
doi_str_mv | 10.1016/j.cherd.2021.04.003 |
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Crystallisation processes are ubiquitous in the food and pharmaceutical industries and the development of process analytical technologies (PAT) for on-line, in situ monitoring is essential to ensure process efficiency and to optimise product quality. Current PAT, many of which are based on electromagnetic waves, have a range of limitations including an inability to accurately measure opaque solutions. Low power (<10Wm−2) pulsed acoustic techniques, such as ultrasound reflectance and velocimetry, have the benefit of being non-material altering, affordable, non-invasive and can study opaque systems without any dilution. Here, we present an improved in-situ ultrasound technique which is corroborated with optical turbidity in the measurement of the MSZW of glycine in water with good agreement. A Mann–Whitney U test was conducted, and no significant difference was found in the measurement of the MSZW between the two techniques. Density data were used with velocity measurements from the improved technique to calculate adiabatic compressibility of glycine solutions, which is an important and useful physical property when studying phase transitions. A frequency space analysis has been performed on the acoustic time domain measurements, and the data suggest the presence of scattering bodies in the metastable zone.</description><identifier>ISSN: 0263-8762</identifier><identifier>EISSN: 1744-3563</identifier><identifier>DOI: 10.1016/j.cherd.2021.04.003</identifier><language>eng</language><publisher>Rugby: Elsevier B.V</publisher><subject>Acoustic spectroscopy ; Acoustics ; Compressibility ; Crystallisation ; Crystallization ; Dilution ; Electromagnetic radiation ; Frequency analysis ; Glycine ; In-situ monitoring ; Measurement ; Monitoring ; Monitoring systems ; MSZW ; Phase transitions ; Studies ; Turbidity ; Ultrasonic imaging ; Ultrasonic methods ; Ultrasonic testing ; Ultrasound ; Velocimetry</subject><ispartof>Chemical engineering research & design, 2021-06, Vol.170, p.213-223</ispartof><rights>2021</rights><rights>Copyright Elsevier Science Ltd. Jun 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c376t-87a89152feab8d9ff8f1c3e22775f98979b088b2170265f4bacdba492e92b0983</citedby><cites>FETCH-LOGICAL-c376t-87a89152feab8d9ff8f1c3e22775f98979b088b2170265f4bacdba492e92b0983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cherd.2021.04.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>Morris, Liam</creatorcontrib><creatorcontrib>Simone, Elena</creatorcontrib><creatorcontrib>Glover, Zachary J.</creatorcontrib><creatorcontrib>Powell, Hugh</creatorcontrib><creatorcontrib>Marty-Terrade, Stéphanie</creatorcontrib><creatorcontrib>Francis, Mathew</creatorcontrib><creatorcontrib>Povey, Megan J.</creatorcontrib><title>Dynamic monitoring of glycine crystallisation with low power ultrasound reflection spectroscopy</title><title>Chemical engineering research & design</title><description>•A improved ultrasound technique is shown to accurately monitor crystallisation.•The optical cloud point can be determined using ultrasound with high accuracy.•Results agree closely with standard optical turbidity.•The ultrasound technique may be detecting scattering bodies in the metastable zone.•The technique may give more information than optical techniques and be used to study structures.
Crystallisation processes are ubiquitous in the food and pharmaceutical industries and the development of process analytical technologies (PAT) for on-line, in situ monitoring is essential to ensure process efficiency and to optimise product quality. Current PAT, many of which are based on electromagnetic waves, have a range of limitations including an inability to accurately measure opaque solutions. Low power (<10Wm−2) pulsed acoustic techniques, such as ultrasound reflectance and velocimetry, have the benefit of being non-material altering, affordable, non-invasive and can study opaque systems without any dilution. Here, we present an improved in-situ ultrasound technique which is corroborated with optical turbidity in the measurement of the MSZW of glycine in water with good agreement. A Mann–Whitney U test was conducted, and no significant difference was found in the measurement of the MSZW between the two techniques. Density data were used with velocity measurements from the improved technique to calculate adiabatic compressibility of glycine solutions, which is an important and useful physical property when studying phase transitions. A frequency space analysis has been performed on the acoustic time domain measurements, and the data suggest the presence of scattering bodies in the metastable zone.</description><subject>Acoustic spectroscopy</subject><subject>Acoustics</subject><subject>Compressibility</subject><subject>Crystallisation</subject><subject>Crystallization</subject><subject>Dilution</subject><subject>Electromagnetic radiation</subject><subject>Frequency analysis</subject><subject>Glycine</subject><subject>In-situ monitoring</subject><subject>Measurement</subject><subject>Monitoring</subject><subject>Monitoring systems</subject><subject>MSZW</subject><subject>Phase transitions</subject><subject>Studies</subject><subject>Turbidity</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonic methods</subject><subject>Ultrasonic testing</subject><subject>Ultrasound</subject><subject>Velocimetry</subject><issn>0263-8762</issn><issn>1744-3563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9UMtOwzAQtBBIlMIXcLHEOcGPJLYPHFB5SpW4wNlyHLt1lMbBTqjy97gtZ0670s7MzgwAtxjlGOHqvs311oQmJ4jgHBU5QvQMLDArioyWFT0HC0QqmnFWkUtwFWOLEEpXvgDyae7Vzmm4870bfXD9BnoLN92sXW-gDnMcVde5qEbne7h34xZ2fg8HvzcBTt0YVPRT38BgbGf0ERSHtAQftR_ma3BhVRfNzd9cgq-X58_VW7b-eH1fPa4zTVk1JmeKC1wSa1TNG2Ett1hTQwhjpRVcMFEjzmuCWQpS2qJWuqlVIYgRpEaC0yW4O-kOwX9PJo6y9VPo00tJyqooWRLHCUVPKJ3sxWRZDsHtVJglRvLQpGzlsUl5aFKiQqYmE-vhxDIpwI8zQUbtTK9N40JKKhvv_uX_As23f4U</recordid><startdate>202106</startdate><enddate>202106</enddate><creator>Morris, Liam</creator><creator>Simone, Elena</creator><creator>Glover, Zachary J.</creator><creator>Powell, Hugh</creator><creator>Marty-Terrade, Stéphanie</creator><creator>Francis, Mathew</creator><creator>Povey, Megan J.</creator><general>Elsevier B.V</general><general>Elsevier Science Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope></search><sort><creationdate>202106</creationdate><title>Dynamic monitoring of glycine crystallisation with low power ultrasound reflection spectroscopy</title><author>Morris, Liam ; Simone, Elena ; Glover, Zachary J. ; Powell, Hugh ; Marty-Terrade, Stéphanie ; Francis, Mathew ; Povey, Megan J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c376t-87a89152feab8d9ff8f1c3e22775f98979b088b2170265f4bacdba492e92b0983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acoustic spectroscopy</topic><topic>Acoustics</topic><topic>Compressibility</topic><topic>Crystallisation</topic><topic>Crystallization</topic><topic>Dilution</topic><topic>Electromagnetic radiation</topic><topic>Frequency analysis</topic><topic>Glycine</topic><topic>In-situ monitoring</topic><topic>Measurement</topic><topic>Monitoring</topic><topic>Monitoring systems</topic><topic>MSZW</topic><topic>Phase transitions</topic><topic>Studies</topic><topic>Turbidity</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonic methods</topic><topic>Ultrasonic testing</topic><topic>Ultrasound</topic><topic>Velocimetry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morris, Liam</creatorcontrib><creatorcontrib>Simone, Elena</creatorcontrib><creatorcontrib>Glover, Zachary J.</creatorcontrib><creatorcontrib>Powell, Hugh</creatorcontrib><creatorcontrib>Marty-Terrade, Stéphanie</creatorcontrib><creatorcontrib>Francis, Mathew</creatorcontrib><creatorcontrib>Povey, Megan J.</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Chemical engineering research & design</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morris, Liam</au><au>Simone, Elena</au><au>Glover, Zachary J.</au><au>Powell, Hugh</au><au>Marty-Terrade, Stéphanie</au><au>Francis, Mathew</au><au>Povey, Megan J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dynamic monitoring of glycine crystallisation with low power ultrasound reflection spectroscopy</atitle><jtitle>Chemical engineering research & design</jtitle><date>2021-06</date><risdate>2021</risdate><volume>170</volume><spage>213</spage><epage>223</epage><pages>213-223</pages><issn>0263-8762</issn><eissn>1744-3563</eissn><abstract>•A improved ultrasound technique is shown to accurately monitor crystallisation.•The optical cloud point can be determined using ultrasound with high accuracy.•Results agree closely with standard optical turbidity.•The ultrasound technique may be detecting scattering bodies in the metastable zone.•The technique may give more information than optical techniques and be used to study structures.
Crystallisation processes are ubiquitous in the food and pharmaceutical industries and the development of process analytical technologies (PAT) for on-line, in situ monitoring is essential to ensure process efficiency and to optimise product quality. Current PAT, many of which are based on electromagnetic waves, have a range of limitations including an inability to accurately measure opaque solutions. Low power (<10Wm−2) pulsed acoustic techniques, such as ultrasound reflectance and velocimetry, have the benefit of being non-material altering, affordable, non-invasive and can study opaque systems without any dilution. Here, we present an improved in-situ ultrasound technique which is corroborated with optical turbidity in the measurement of the MSZW of glycine in water with good agreement. A Mann–Whitney U test was conducted, and no significant difference was found in the measurement of the MSZW between the two techniques. Density data were used with velocity measurements from the improved technique to calculate adiabatic compressibility of glycine solutions, which is an important and useful physical property when studying phase transitions. A frequency space analysis has been performed on the acoustic time domain measurements, and the data suggest the presence of scattering bodies in the metastable zone.</abstract><cop>Rugby</cop><pub>Elsevier B.V</pub><doi>10.1016/j.cherd.2021.04.003</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Acoustic spectroscopy Acoustics Compressibility Crystallisation Crystallization Dilution Electromagnetic radiation Frequency analysis Glycine In-situ monitoring Measurement Monitoring Monitoring systems MSZW Phase transitions Studies Turbidity Ultrasonic imaging Ultrasonic methods Ultrasonic testing Ultrasound Velocimetry |
title | Dynamic monitoring of glycine crystallisation with low power ultrasound reflection spectroscopy |
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